Selective inhibition of CCR7- effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model

Journal of Biological Chemistry

Volumn 287, Issue 35, 2012, Pages 29479-29494

  Li, Zhi ^a   Liu, Wan Hong ^a   Han, Song ^a   Peng, Bi Wen ^a   Yin, Jun ^a   Wu, Ying Liang ^a   He, Xiao Hua ^a   Li, Wen Xin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE EXPRESSION PATTERNS; MEMORY T CELLS; MULTIPLE FUNCTION; MULTIPLE SCLEROSIS; PROTEIN KINASE C; SELECTIVE INHIBITION; SIDE EFFECT; T CELLS; THERAPEUTIC TARGETS;

CYTOLOGY; GENE EXPRESSION; PEPTIDES; RATS;

CELLS;

CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; MESSENGER RNA; PEPTIDE ADWX 1; POTASSIUM CHANNEL KV1.3; PROTEIN KINASE C; SYNTHETIC PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SELECTIVITY; DRUG TARGETING; FEMALE; GENE; GENE EXPRESSION; KV1.3 GENE; LYMPHOCYTE DIFFERENTIATION; MEMORY T LYMPHOCYTE; MULTIPLE SCLEROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH17 CELL; TRANSCRIPTION REGULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; JURKAT CELLS; KV1.3 POTASSIUM CHANNEL; MULTIPLE SCLEROSIS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CCR7; RNA, MESSENGER;

RATTUS;

EID: 84865476388     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.379594     Document Type: Article

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