Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 9, 2012, Pages 4718-4728

  Adedeji, Adeyemi O ^a   Singh, Kamalendra ^a   Calcaterra, Nicholas E ^a   DeDiego, Marta L ^b   Enjuanes, Luis ^b   Weiss, Susan ^c   Sarafianos, Stefan G ^a  

^a University of Missouri   (United States)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(2 NITROPHENYL)SULFANYLMETHYL] 4 PROP 2 ENYL 1H 1,2,4 TRIAZOLE 5 THIONE; ANTIVIRUS AGENT; BACTERIAL RNA; CELL ENZYME; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; HELICASE; RNA DIRECTED RNA POLYMERASE; RNA HELICASE; SSYA10 001; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CYTOTOXICITY; DNA BINDING; DNA DENATURATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; NONHUMAN; PRIORITY JOURNAL; REPLICON; RNA BINDING; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELL SURVIVAL; DNA HELICASES; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; NUCLEIC ACID CONFORMATION; RECOMBINANT PROTEINS; RNA, DOUBLE-STRANDED; RNA, VIRAL; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SMALL MOLECULE LIBRARIES; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84865427975     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00957-12     Document Type: Article

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