Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1636-1638

  Lee, Chaewoon ^a   Lee, Jin Moo ^b   Lee, Na Ra ^b   Jin, Bong Suk ^b   Jang, Kyoung Jin ^a   Kim, Dong Eun ^a   Jeong, Yong Joo ^b   Chong, Youhoon ^a  

^a Konkuk University   (South Korea)

^b Kookmin University   (South Korea)

Author keywords

Aryl diketoacid (ADK); Duplex DNA unwinding activity; Helicase; SARS CoV

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTIVIRUS AGENT; BISMUTH DERIVATIVE; DIOXOACID DERIVATIVE; DOUBLE STRANDED DNA; HE 602; HELICASE; NUCLEOSIDE TRIPHOSPHATASE; OXOACID; PHOSPHATE; UNCLASSIFIED DRUG; VANILLINBANANIN; ZINC ION;

ARTICLE; DNA DENATURATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; IC 50; NONHUMAN; SARS CORONAVIRUS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DNA; DNA HELICASES; DRUG DESIGN; FLUORESCENCE RESONANCE ENERGY TRANSFER; INHIBITORY CONCENTRATION 50; IONS; KETO ACIDS; MODELS, CHEMICAL; NUCLEOSIDE-TRIPHOSPHATASE; PHOSPHATES; SARS VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

HEPATITIS C VIRUS; SARS CORONAVIRUS; STRAWBERRY CRINKLE VIRUS;

EID: 61349161228     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.010     Document Type: Article

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