New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease

Nature Medicine

Volumn 8, Issue 4, 2002, Pages 392-398

  Kleymann, Gerald ^a   Fischer, Rüdiger ^a   Betz, Ulrich A K ^a   Hendrix, Martin ^a   Bender, Wolfgang ^a   Schneider, Udo ^a   Handke, Gabriele ^a   Eckenberg, Peter ^a   Hewlett, Guy ^a   Pevzner, Veniamin ^a   Baumeister, Judith ^a   Weber, Olaf ^a   Henninger, Kerstin ^a   Keldenich, Jörg ^a   Jensen, Axel ^a   Kolb, Jörg ^a   Bach, Ute ^a   Popp, Andreas ^a   Mäben, Jutta ^a   Frappa, Isabelle ^a   Haebich, Dieter ^a   Lockhoff, Oswald ^a   Rübsamen Waigmann, Helga ^a   more..

^a BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

[N [5 (AMINOSULFONYL) 4 METHYL 1,3 THIAZOL 2 YL] N METHYL 2 [4 (2 PYRIDINYL)PHENYL]ACETAMIDE]; ACICLOVIR; ANTIVIRUS AGENT; BAY 389489; BAY 445138; BAY 513295; BAY 546322; BAY 57 1293; DNA POLYMERASE; DNA PRIMASE; ENZYME INHIBITOR; HELICASE; UNCLASSIFIED DRUG; VALACICLOVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS; HERPES VIRUS INFECTION; HIGH RISK POPULATION; IMMUNE DEFICIENCY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECURRENT DISEASE;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; DNA HELICASES; DNA PRIMASE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FEMALE; GUINEA PIGS; HERPES SIMPLEX; HUMANS; INFANT, NEWBORN; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; PREGNANCY; PYRIDINES; SAFETY; THIAZOLES; VIRAL PROTEINS;

ANIMALIA; DNA VIRUSES; HERPESVIRIDAE; SIMPLEXVIRUS;

EID: 0036111626     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0402-392     Document Type: Article

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