Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Patrushev, Nikolay ^a   Seidel Rogol, Bonnie ^a   Salazar, Gloria ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN II; CATALASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER; ZINC TRANSPORTER 10 PROTEIN; ZINC TRANSPORTER 3 PROTEIN; CATION TRANSPORT PROTEIN; ZINC TRANSPORTER 3, RAT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL LEVEL; CELL TRANSPORT; CELL VACUOLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENDOSOME; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STABILITY; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE; ANIMAL; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

MAMMALIA;

ANGIOTENSIN II; ANIMALS; BLOTTING, WESTERN; CATION TRANSPORT PROTEINS; CELL AGING; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; ZINC;

EID: 84858045324     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033211     Document Type: Article

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