Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure

Journal of Diabetes

Volumn 4, Issue 3, 2012, Pages 297-306

  Bruin, Jennifer E ^a,b   Woynillowicz, Amanda K ^a   Hettinga, Bart P ^a   Tarnopolsky, Mark A ^a   Morrison, Katherine M ^a   Gerstein, Hertzel C ^a   Holloway, Alison C ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

cell mass; Antioxidant therapy; Insulin glucagon bihormonal cells; Nicotine; Pancreas development

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; GLUCAGON; INSULIN; NICOTINE TARTRATE; SODIUM CHLORIDE; THIOCTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIRTH WEIGHT; CELL LOSS; CELL PROLIFERATION; COENZYME; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENDOCRINE CELL; EXPOSURE; FEMALE; LACTATION; MALE; MATING; NONHUMAN; NULLIPARA; PANCREAS ISLET BETA CELL; PREGNANCY; PRIORITY JOURNAL; PROGENY; RAT; WEANING; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; APOPTOSIS; BIRTH WEIGHT; BODY WEIGHT; CELL PROLIFERATION; DIET; FEMALE; GANGLIONIC STIMULANTS; GLUCAGON; INJECTIONS, SUBCUTANEOUS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; NICOTINE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; TIME FACTORS; WEANING;

EID: 84865322778     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/j.1753-0407.2012.00195.x     Document Type: Article

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