The potential role of combined antioxidant treatment on pancreas of STZ-diabetic mice

Experimental and Toxicologic Pathology

Volumn 65, Issue 3, 2013, Pages 255-262

  Karatug, Ayse ^a   Bolkent, Sehnaz ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Diabetes; Mice; Mitochondrial and cytosolic antioxidative systems; Oxidative stress; Pancreas

Indexed keywords

ALPHA TOCOPHEROL; CATALASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INSULIN; LIPID PEROXIDASE; MANGANESE SUPEROXIDE DISMUTASE; SELENIUM; STREPTOZOCIN; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL FRACTIONATION; CELL LEVEL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOPLASM; DIABETES MELLITUS; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS; STREPTOZOCIN DIABETES;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; MICE; OXIDATIVE STRESS; PANCREAS; SELENIUM; STREPTOZOCIN; THIOCTIC ACID; TREATMENT OUTCOME; VITAMIN E;

MUS;

EID: 84872804094     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2011.08.012     Document Type: Article

References (66)

1. Aebi H. Catalase in vitro. Methods in Enzymology 1984, 105:121-126.
2. Altan N., Sepici Dinçel A., Koca C. Diabetes mellitus ve oksidatif stres. Turkish Journal of Biochemistry 2006, 31(2):51-56.
3. Aughsteen A.A. An ultrastructural study on the effect of streptozotocin on the islets of Langerhans in mice. Journal of Electron Microscopy (Tokyo) 2000, 49(5):681-690.
4. Barbosa N.B., Rocha J.B., Soares J.C., Wondracek D.C., Goncalves J.F., et al. Dietary diphenyl diselenide reduces the STZ-induced toxicity. Food and Chemical Toxicology 2008, 46(1):186-194.
5. Bastar I., Seckin S., Uysal M., Aykac Toker G. Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats. Research Communications in Molecular Pathology & Pharmacology 1998, 102(3):265-272.
6. Berryman A.M., Maritim A.C., Sanders R.A., Watkins J.B. Influence of treatment of diabetic rats with combinations of pycnogenol, beta-carotene, and alpha-lipoic acid on parameters of oxidative stress. Journal of Biochemical and Molecular Toxicology 2004, 18(6):345-352.
7. Beutler E. Glutathione in red blood cell metabolism, a manual of biochemical methods 1975, vol. 36. Grune and Stratton, New York, p. 112-4. second ed.
8. Bhor V.M., Raghuram N., Sivakami S. Oxidative damage and altered antioxidant enzyme activities in the small intestine of streptozotocin-induced diabetic rats. The International Journal of Biochemistry & Cell Biology 2004, 36(1):89-97.
9. Ho E., Bray T.M. Antioxidants, NFkappaB activation, and diabetogenesis. Proceedings of the Society for Experimental Biology and Medicine 1999, 222(3):205-213.
10. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods in Enzymology 1978, 52:302-310.
11. Busse E., Zimmer G., Schopohl B., Kornhuber B. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung 1992, 42(6):829-831.
12. Clark A., Jones L.C., De Koning E., Hansen B.C., Matthews D.R. Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?. Diabetes 2001, 50(1):S169-S171.
13. Coskun O., Kanter M., Korkmaz A., Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacological Research 2005, 51(2):117-123.
14. Di Leo M.A., Santini S.A., Silveri N.G., Giardina B., Franconi F., Ghirlanda G. Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats. Amino Acids 2004, 27(2):187-191.
15. Dincer Y., Telci A., Kayali R., Yilmaz I.A., Cakatay U., Akcay T. Effect of alpha-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats. Clinical and Experimental Pharmacology and Physiology 2002, 29(4):281-284.
16. Eskew M.L., Scholz R.W., Reddy C.C., Todhunter D.A., Zarkower A. Effects of vitamin E and selenium deficiencies on rat immune function. Immunology 1985, 54(1):173-180.
17. Flohe L., Becker R., Brigelius R., Lengfelder E., Otting F. CRC handbook of free radicals and antioxidants in biomedicine, convenient assays for superoxide dismutase 1989, vol. 3. CRC Press, Inc., Boca Raton, FL, p. 287-93.
18. Foster T.S. Efficacy and safety of alpha-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy. The Diabetes Educator 2007, 33(1):111-117.
19. Gezginci Oktayoglu S., Bolkent S. Exendin-4 exerts its effects through the NGF/p75NTR system in diabetic mouse pancreas. Biochemistry and Cell Biology 2009, 87(4):641-651.
20. Gocmen C., Secilmis A., Kumcu E.K., Ertug P.U., Onder S., Dikmen A., et al. Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. European Journal of Pharmacology 2000, 398(1):93-98.
21. Góth L., Eaton J.W. Hereditary catalase deficiencies and increased risk of diabetes. The Lancet 2000, 356(9244):1820-1821.
22. Heales S.J. Catalase deficiency, diabetes, and mitochondrial function. The Lancet 2001, 357(9252):314.
23. Hoekstra W.G. Biochemical function of selenium and its relation to vitamin E. Federation Proceedings 1975, 34(11):2083-2089.
24. Jang Y.Y., Song J.H., Shin Y.K., Han E.S., Lee C.S. Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats. Pharmacological Research 2000, 42(4):361-371.
25. Jin H.R., Kim W.J., Song J.S., Choi M.J., Piao S., Shin S.H., et al. Functional and morphologic characterizations of the diabetic mouse corpus cavernosum: comparison of a multiple low-dose and a single high-dose streptozotocin protocols. The Journal of Sexual Medicine 2009, 6(12):3289-3304.
26. Kanbagli O., Balkan J., Aykac Toker G., Uysal M. Hepatic mitochondrial prooxidant and antioxidant status in ethanol-induced liver injury in rats. Biological &Pharmaceutical Bulletin 2002, 25(11):1482-1484.
27. Kaneto H., Kajimoto Y., Miyagawa J., Matsuoka T., Fujitani Y., Umayahara Y., et al. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 1999, 48(12):2398-2406.
28. Kaneto H., Matsuoka T.A., Nakatani Y., Kawamori D., Matsuhisa M., Yamasaki Y. Oxidative stress and the JNK pathway in diabetes. Current Diabetes Reviews 2005, 1(1):65-72.
29. Kannan K., Jain S.K. Oxidative stress and apoptosis. Pathophysiology 2000, 7(3):153-163.
30. Kawasaki F., Matsuda M., Kanda Y., Inoue H., Kaku K. Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice. American Journal of Physiology-Endocrinology and Metabolism 2005, 288(3):E510-E518.
31. Khamaisi M., Rudich A., Potashnik R., Tritschler H.J., Gutman A., Bashan N. Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. Metabolism 1999, 48(4):504-510.
32. Kojima M., Sun L., Hata I., Sakamoto Y., Sasaki H., Sasaki K. Efficacy of alpha-lipoic acid against diabetic cataract in rat. Japanese Journal of Ophthalmology 2007, 51(1):10-13.
33. Kowluru R.A., Kowluru V., Xiong Y., Ho Y.S. Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Free Radical Biology and Medicine 2006, 41(8):1187-1190.
34. Koyuturk M., Ozsoy Sacan O., Bolkent S., Yanardag R. Effect of glurenorm on immunohistochemical changes in pancreatic beta cells of rats in experimental diabetes. Indian Journal of Experimental Biology 2005, 43(3):268-271.
35. Lateef H., Aslam M.N., Stevens M.J., Varani J. Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds. Archives of Dermatological Research 2005, 297(2):75-83.
36. Leach M.J. Gymnema sylvestre for diabetes mellitus: a systematic review. Journal of Alternative and Complementary Medicine 2007, 13(9):977-983.
37. Lebovitz R.M., Zhang H., Vogel H., Cartwright J., Dionne L., Lu N., et al. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 1996, 93(18):9782-9787.
38. Li Y., Huang T.T., Carlson E.J., Melov S., Ursell P.C., Olson J.L., et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature Genetics 1995, 11(4):376-381.
39. Like A.A., Rossini A.A. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 1976, 193:415-424.
40. Maritim A.C., Sanders R.A., Watkins J.B. Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. The Journal of Nutritional Biochemistry 2003, 14(5):288-294.
41. McCord J.M., Fridovich I. Superoxide dismutase, an enzymic function for erythrocuprein (hemocuprein). The Journal of Biological Chemistry 1969, 244(22):6049-6055.
42. Modak M., Dixit P., Londhe J., Ghaskadbi S., Devasagayam T.P.A. Indian herbs and herbal drugs used for the treatment of diabetes. Journal of Clinical Biochemistry & Nutrition 2007, 40(3):163-173.
43. Mukherjee B., Anbazhagan S., Roy A., Ghosh R., Chatterjee M. Novel implications of the potential role of selenium on antioxidant status in streptozotocin-induced diabetic mice. Biomedicine & Pharmacotherapy 1998, 52(2):89-95.
44. Obrosova I.G., Fathallah L., Liu E., Nourooz Zadeh J. Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acid. Free Radical Biology and Medicine 2003, 34(2):186-195.
45. Ozkan Y., Yilmaz O., Ozturk A.I., Ersan Y. Effects of triple antioxidant combination (vitamin E, vitamin C and alpha-lipoic acid) with insulin on lipid and cholesterol levels and fatty acid composition of brain tissue in experimental diabetic and non-diabetic rats. Cell Biology International 2005, 29(9):754-760.
46. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 1967, 70(1):158-169.
47. Papaccio G., Pisanti F.A., Latronico M.V., Ammendola E., Galdieri M. Multiple low-dose and single high-dose treatments with streptozotocin do not generate nitric oxide. Journal of Cellular Biochemistry 2000, 77(1):82-91.
48. Raza H., Prabu S.K., Robin M.A., Avadhani N.G. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Diabetes 2004, 53(1):185-194.
49. Reaume A.G., Elliott J.L., Hoffman E.K., Kowall N.W., Ferrante R.J., Siwek D.F., et al. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nature Genetics 1996, 13(1):43-47.
50. Reddi A.S., Bollineni J.S. Selenium-deficient diet induces renal oxidative stress and injury via TGF-beta1 in normal and diabetic rats. Kidney International 2001, 59(4):1342-1353.
51. Rungby J., Flyvbjerg A., Andersen H.B., Nyborg K. Lipid peroxidation in early experimental diabetes in rats: effects of diabetes and insulin. Acta Endocrinologica (Copenh) 1992, 126(4):378-380.
52. Sadi G., Yilmaz O., Guray T. Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of Cu-Zn SOD and catalase. Molecular and Cellular Biochemistry 2008, 309(1-2):109-116.
53. Seven A., Guzel S., Seymen O., Civelek S., Bolayirli M., Uncu M., et al. Effects of vitamin E supplementation on oxidative stress in streptozotocin induced diabetic rats: investigation of liver and plasma. Yonsei Medical Journal 2004, 45(4):703-710.
54. Shao J., Iwashita N., Ikeda F., Ogihara T., Uchida T., Shimizu T., et al. Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice. Biochemical and Biophysical Research Communications 2006, 344(4):1224-1233.
55. Shirpoor A., Ansari M.H., Salami S., Pakdel F.G., Rasmi Y. Effect of vitamin E on oxidative stress status in small intestine of diabetic rat. World Journal of Gastroenterology 2007, 13(32):4340-4344.
56. Slonim A.E., Surber M.L., Page D.L., Sharp R.A., Burr I.M. Modification of chemically induced diabetes in rats by vitamin E. Supplementation minimizes and depletion enhances development of diabetes. Journal of Clinical Investigation 1983, 71(5):1282-1288.
57. Somani S.M., Husain K., Whitworth C., Trammell G.L., Malafa M., Rybak L.P. Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: antioxidant defense system. Pharmacology & Toxicology 2000, 86(5):234-241.
58. Srinivasan K., Ramarao P. Animal models in type 2 diabetes research: an overview. Indian Journal of Medical Research 2007, 125(3):451-472.
59. Sun Y., Oberley L.W., Ying L. A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 1988, 34:497-500.
60. Wada R., Yagihashi S. Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin. Virchows Archiv 2004, 444(4):375-382.
61. West I.C. Radicals and oxidative stress in diabetes. Diabetic Medicine 2000, 17(3):171-180.
62. Wohaieb S.A., Godin D.V. Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment. Diabetes 1987, 36(9):1014-1018.
63. Yamamoto H., UchigataY, Okamoto H. Streptozotocin and alloxan induce DNA strand breaks and poly(ADPribose) synthetase in pancreatic islets. Nature (Lond) 1981, 294:284-286.
64. Yanardag R., Bolkent S., Tabakoglu Oguz A., Ozsoy Sacan O. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biological & Pharmaceutical Bulletin 2003, 26(8):1206-1210.
65. Yi X., Maeda N. Alpha-lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes 2006, 55(8):2238-2240.
66. Zhang F., Xu Z., Gao J., Xu B., Deng Y. In vitro effect of manganese chloride exposure on energy metabolism and oxidative damage of mitochondria isolated from rat brain. Environmental Toxicology and Pharmacology 2008, 26:232-236.