Norisoboldine, an alkaloid compound isolated from Radix Linderae, inhibits synovial angiogenesis in adjuvant-induced arthritis rats by moderating Notch1 pathway-related endothelial tip cell phenotype

Experimental Biology and Medicine

Volumn 237, Issue 8, 2012, Pages 919-932

  Lu, Qian ^a   Lu, Shuai ^b   Gao, Xinghua ^a   Luo, Yubin ^a   Tong, Bei ^a   Wei, Zhifeng ^a   Lu, Tao ^b   Xia, Yufeng ^a   Chou, Guixin ^c   Wang, Zhengtao ^a   Dai, Yue ^a  

^a China Pharmaceutical University   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Angiogenesis; Norisoboldine; Notch1; Rheumatoid arthritis; Tip cells

Indexed keywords

ALKALOID; N [N [2 (3,5 DIFLUOROPHENYL)ACETYL]ALANYL]PHENYLGLYCINE TERT BUTYL ESTER; NORISOBOLDINE; NOTCH1 RECEPTOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; DRUG ISOLATION; DRUG MECHANISM; ENDOTHELIUM CELL; EXPERIMENTAL RAT; IN VITRO STUDY; MOLECULAR DOCKING; PHENOTYPE; PLANT ROOT; RADIX LINDERAE; SYNOVIUM;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS; MALE; MICE; NEOVASCULARIZATION, PATHOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NOTCH1; SYNOVIAL FLUID;

EID: 84865322201     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.011416     Document Type: Article

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