Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2) fail to inhibit endothelial cell proliferation or formation of microvessels from rat aortic rings in vitro

Angiogenesis

Volumn 7, Issue 2, 2004, Pages 91-96

  Garrabrant, Thomas ^a   Tuman, Robert ^a   Ludovici, Don ^a   Tominovich, Rose ^a   Simoneaux, Richard ^a   Galemmo, Robert ^a  

^a LLC Welsh McKean Roads S ^*  (United States)

Author keywords

angiogenesis; endothelial cell proliferation; fumagillin; methionine aminopeptidase; microvessel outgrowth

Indexed keywords

ANGIOGENESIS INHIBITOR; COBALT; DIVALENT CATION; EDETIC ACID; ENZYME INHIBITOR; FUMAGILLIN; GROWTH FACTOR; JNJ 4929821; MANGANESE; METHIONINE AMINOPEPTIDASE 1; METHIONINE AMINOPEPTIDASE 2; METHIONYL AMINOPEPTIDASE; RECOMBINANT ENZYME; TIAZOFURIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; ENDOTHELIUM CELL; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MICROVASCULATURE; NONHUMAN; ONCOLOGY; PRIORITY JOURNAL; RAT; VASCULAR RING;

AMINOPEPTIDASES; ANGIOGENESIS INHIBITORS; AORTA; CELL PROLIFERATION; CYCLOHEXANES; DRUG EVALUATION, PRECLINICAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; GLYCOPROTEINS; HUMANS; METALLOENDOPEPTIDASES; NEOVASCULARIZATION, PHYSIOLOGIC; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; UMBILICAL VEINS;

ANIMALIA;

EID: 8544232793     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-004-6089-7     Document Type: Article

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