Norisoboldine inhibits the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 cells by down-regulating the activation of MAPKs but not NF-κB

Inflammation

Volumn 33, Issue 6, 2010, Pages 389-397

  Luo, Yubin ^a   Liu, Mei ^a   Dai, Yue ^a   Yao, Xiujuan ^a   Xia, Yufeng ^a   Chou, Guixin ^b   Wang, Zhengtao ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Macrophage; Norisoboldine; Pro inflammatory cytokines; Signaling pathways

Indexed keywords

ALKALOID DERIVATIVE; CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NORISOBOLDINE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CELL STIMULATION; CELL STRAIN RAW 264.7; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; INHIBITION KINETICS; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN DEGRADATION;

ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; PHOSPHORYLATION; TUMOR NECROSIS FACTOR-ALPHA;

LAURACEAE; LINDERA AGGREGATA; MUS;

EID: 78549231234     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-010-9197-0     Document Type: Article

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