메뉴 건너뛰기




Volumn 9, Issue 9, 2012, Pages 1069-1081

Thiomers and thiomer-based nanoparticles in protein and DNA drug delivery

Author keywords

DNA drugs; Nanoparticles; Oral delivery; Protein drugs; Thiomers

Indexed keywords

2 IMINOTHIOLANE; ANTISENSE OLIGONUCLEOTIDE; CALCITONIN; CARBOXYMETHYLCELLULOSE; CHITOSAN; CHITOSAN DERIVATIVE; CYCLODEXTRIN; ENKEPHALIN; EXCIPIENT; GELATIN; GLYCOPROTEIN P; GREEN FLUORESCENT PROTEIN; HYDROGEN PEROXIDE; INSULIN; LEUPRORELIN; LIPOFECTIN; MERCAPTAMINE; NANOCARRIER; NUCLEOPHILE; PECTIN; PLASMID DNA; POLYACRYLIC ACID; POLYCARBOPHIL; RHODAMINE 123; SODIUM SULFATE; THIOGLYCOLIC ACID; THIOMER NANOPARTICLE; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG;

EID: 84865319222     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2012.697893     Document Type: Review
Times cited : (21)

References (87)
  • 1
    • 39449092067 scopus 로고    scopus 로고
    • Thiolated chitosans: Useful excipients for oral drug delivery
    • DOI 10.1211/jpp.60.3.3001
    • Werle M, Bernkop-Schnurch A. Thiolated chitosans: useful excipients for oral drug delivery. J Pharm Pharmacol 2008;60(3):273-81 (Pubitemid 351269813)
    • (2008) Journal of Pharmacy and Pharmacology , vol.60 , Issue.3 , pp. 273-281
    • Werle, M.1    Bemkop-Schnurch, A.2
  • 2
    • 36248965689 scopus 로고    scopus 로고
    • Current challenges in non-invasive insulin delivery systems: A comparative review
    • DOI 10.1016/j.addr.2007.08.019, PII S0169409X07001913
    • Khafagy E-S, Morishita M, Onuki Y, Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev 2007;59(15):1521-46 (Pubitemid 350122777)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.15 , pp. 1521-1546
    • Khafagy, E.-S.1    Morishita, M.2    Onuki, Y.3    Takayama, K.4
  • 3
    • 70349998626 scopus 로고    scopus 로고
    • Therapeutic application of peptides and proteins: Parenteral forever?
    • Antosova Z, Mackova M, Kral V, Macek T. Therapeutic application of peptides and proteins: parenteral forever? Trends Biotechnol 2009;27(11):628-35
    • (2009) Trends Biotechnol , vol.27 , Issue.11 , pp. 628-635
    • Antosova, Z.1    MacKova, M.2    Kral, V.3    MacEk, T.4
  • 4
    • 18244365849 scopus 로고    scopus 로고
    • Protein drug stability: A formulation challenge
    • DOI 10.1038/nrd1695
    • Frokjaer S, Otzen DE. Protein drug stability: a formulation challenge. Nat Rev Drug Discov 2005;4(4):298-306 (Pubitemid 41130943)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.4 , pp. 298-306
    • Frokjaer, S.1    Otzen, D.E.2
  • 5
    • 33746565966 scopus 로고    scopus 로고
    • The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis
    • DOI 10.1016/j.bioeng.2006.05.026, PII S1389034406000670
    • Emerich DF, Thanos CG. The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis. Biomol Eng 2006;23(4):171-84 (Pubitemid 44142336)
    • (2006) Biomolecular Engineering , vol.23 , Issue.4 , pp. 171-184
    • Emerich, D.F.1    Thanos, C.G.2
  • 7
    • 33645691940 scopus 로고    scopus 로고
    • Engineered nanoparticles as precise drug delivery systems
    • Yih TC, Al-Fandi M. Engineered nanoparticles as precise drug delivery systems. J Cell Biochem 2006;97(6):1184-90
    • (2006) J Cell Biochem , vol.97 , Issue.6 , pp. 1184-1190
    • Yih, T.C.1    Al-Fandi, M.2
  • 8
    • 33751253462 scopus 로고    scopus 로고
    • Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
    • DOI 10.1016/j.jconrel.2006.08.013, PII S0168365906004020
    • des Rieux A, Fievez V, Garinot M, et al. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 2006;116(1):1-27 (Pubitemid 44792295)
    • (2006) Journal of Controlled Release , vol.116 , Issue.1 , pp. 1-27
    • Des Rieux, A.1    Fievez, V.2    Garinot, M.3    Schneider, Y.-J.4    Preat, V.5
  • 9
    • 79954420700 scopus 로고    scopus 로고
    • Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents
    • Chaudhury A, Das S. Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents. AAPS PharmSciTech 2011;12(1):10-20
    • (2011) AAPS PharmSciTech , vol.12 , Issue.1 , pp. 10-20
    • Chaudhury, A.1    Das, S.2
  • 10
    • 79954628593 scopus 로고    scopus 로고
    • Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery
    • Makhlof A, Tozuka Y, Takeuchi H. Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur J Pharm Sci 2011;42(5):445-51
    • (2011) Eur J Pharm Sci , vol.42 , Issue.5 , pp. 445-451
    • Makhlof, A.1    Tozuka, Y.2    Takeuchi, H.3
  • 11
    • 26644434123 scopus 로고    scopus 로고
    • Comparison of the mucoadhesive properties of various polymers
    • DOI 10.1016/j.addr.2005.07.006, PII S0169409X05001468, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • Grabovac V, Guggi D, Bernkop-Schnurch A. Comparison of the mucoadhesive properties of various polymers. Adv Drug Deliv Rev 2005;57(11):1713-23 (Pubitemid 41443475)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1713-1723
    • Grabovac, V.1    Guggi, D.2    Bernkop-Schnurch, A.3
  • 12
    • 0036892411 scopus 로고    scopus 로고
    • In vitro evaluation of the permeation enhancing effect of polycarbophil-cysteine conjugates on the cornea of rabbits
    • DOI 10.1002/jps.10258
    • Hornof MD, Bernkop-Schnurch A. In vitro evaluation of the permeation enhancing effect of polycarbophil-cysteine conjugates on the cornea of rabbits. J Pharm Sci 2002;91(12):2588-92 (Pubitemid 35385624)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.12 , pp. 2588-2592
    • Hornof, M.D.1    Bernkop-Schnurch, A.2
  • 13
    • 0038015493 scopus 로고    scopus 로고
    • Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil
    • DOI 10.1023/A:1023803706746
    • Kast CE, Guggi D, Langoth N, Bernkop-Schnurch A. Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil. Pharm Res 2003;20(6):931-6 (Pubitemid 36628442)
    • (2003) Pharmaceutical Research , vol.20 , Issue.6 , pp. 931-936
    • Kast, C.E.1    Guggi, D.2    Langoth, N.3    Bernkop-Schnurch, A.4
  • 14
    • 0035937594 scopus 로고    scopus 로고
    • Mucoadhesive nanoparticulate systems for peptide drug delivery
    • DOI 10.1016/S0169-409X(00)00120-4, PII S0169409X00001204
    • Takeuchi H, Yamamoto H, Kawashima Y. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Deliv Rev 2001;47(1):39-54 (Pubitemid 32209231)
    • (2001) Advanced Drug Delivery Reviews , vol.47 , Issue.1 , pp. 39-54
    • Takeuchi, H.1    Yamamoto, H.2    Kawashima, Y.3
  • 15
    • 33344454616 scopus 로고    scopus 로고
    • Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine
    • DOI 10.1016/j.jconrel.2005.11.011, PII S0168365905006541
    • Werle M, Hoffer M. Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine. J Control Release 2006;111(1-2):41-6 (Pubitemid 43289993)
    • (2006) Journal of Controlled Release , vol.111 , Issue.1-2 , pp. 41-46
    • Werle, M.1    Hoffer, M.2
  • 16
    • 33646159752 scopus 로고    scopus 로고
    • In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan
    • Foger F, Schmitz T, Bernkop-Schnurch A. In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials 2006;27(23):4250-5
    • (2006) Biomaterials , vol.27 , Issue.23 , pp. 4250-4255
    • Foger, F.1    Schmitz, T.2    Bernkop-Schnurch, A.3
  • 17
    • 34249810030 scopus 로고    scopus 로고
    • Thiomers: Forms, functions and applications to nanomedicine
    • DOI 10.2217/17435889.2.1.41
    • Albrecht K, Bernkop-Schnurch A. Thiomers: forms, functions and applications to nanomedicine. Nanomedicine (Lond) 2007;2(1):41-50 (Pubitemid 46845775)
    • (2007) Nanomedicine , vol.2 , Issue.1 , pp. 41-50
    • Albrecht, K.1    Bernkop-Schnurch, A.2
  • 18
    • 0038460837 scopus 로고    scopus 로고
    • Thiolated polymers - Thiomers: Synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates
    • DOI 10.1016/S0378-5173(03)00271-0
    • Bernkop-Schnurch A, Hornof M, Zoidl T. Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int J Pharm 2003;260(2):229-37 (Pubitemid 36773920)
    • (2003) International Journal of Pharmaceutics , vol.260 , Issue.2 , pp. 229-237
    • Bernkop-Schnurch, A.1    Hornof, M.2    Zoidl, T.3
  • 19
    • 4444265622 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of a novel thiolated chitosan
    • DOI 10.1016/j.biomaterials.2004.03.011, PII S0142961204002546
    • Kafedjiiski K, Krauland AH, Hoffer MH, Bernkop-Schnurch A. Synthesis and in vitro evaluation of a novel thiolated chitosan. Biomaterials 2005;26(7):819-26 (Pubitemid 39179966)
    • (2005) Biomaterials , vol.26 , Issue.7 , pp. 819-826
    • Kafedjiiski, K.1    Krauland, A.H.2    Hoffer, M.H.3    Bernkop-Schnurch, A.4
  • 20
    • 70449597666 scopus 로고    scopus 로고
    • Chitosan-graft-6-mercaptonicotinic acid: Synthesis, characterization, and biocompatibility
    • Millotti G, Samberger C, Frohlich E, Bernkop-Schnurch A. Chitosan-graft-6-mercaptonicotinic acid: synthesis, characterization, and biocompatibility. Biomacromolecules 2009;10(11):3023-7
    • (2009) Biomacromolecules , vol.10 , Issue.11 , pp. 3023-3027
    • Millotti, G.1    Samberger, C.2    Frohlich, E.3    Bernkop-Schnurch, A.4
  • 21
  • 22
    • 79955974592 scopus 로고    scopus 로고
    • Design and synthesis of a novel cationic thiolated polymer
    • Rahmat D, Sakloetsakun D, Shahnaz G, et al. Design and synthesis of a novel cationic thiolated polymer. Int J Pharm 2011;411(1-2):10-17
    • (2011) Int J Pharm , vol.411 , Issue.1-2 , pp. 10-17
    • Rahmat, D.1    Sakloetsakun, D.2    Shahnaz, G.3
  • 23
    • 26644452975 scopus 로고    scopus 로고
    • Thiomers: A new generation of mucoadhesive polymers
    • DOI 10.1016/j.addr.2005.07.002, PII S0169409X05001407, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • Bernkop-Schnurch A. Thiomers: a new generation of mucoadhesive polymers. Adv Drug Deliv Rev 2005;57(11):1569-82 (Pubitemid 41443470)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1569-1582
    • Bernkop-Schnurch, A.1
  • 24
    • 0033020555 scopus 로고    scopus 로고
    • Polymers with thiol groups: A new generation of mucoadhesive polymers?
    • DOI 10.1023/A:1018830204170
    • Bernkop-Schnurch A, Schwarz V, Steininger S. Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm Res 1999;16(6):876-81 (Pubitemid 29284199)
    • (1999) Pharmaceutical Research , vol.16 , Issue.6 , pp. 876-881
    • Bernkop-Schnurch, A.1    Schwarz, V.2    Steininger, S.3
  • 25
    • 0035845737 scopus 로고    scopus 로고
    • Thiolated polymers: Synthesis and in vitro evaluation of polymer-cysteamine conjugates
    • DOI 10.1016/S0378-5173(01)00807-9, PII S0378517301008079
    • Bernkop-Schnurch A, Clausen AE, Hnatyszyn M. Thiolated polymers: synthesis and in vitro evaluation of polymer-cysteamine conjugates. Int J Pharm 2001;226(1-2):185-94 (Pubitemid 32800793)
    • (2001) International Journal of Pharmaceutics , vol.226 , Issue.1-2 , pp. 185-194
    • Bernkop-Schnurch, A.1    Clausen, A.E.2    Hnatyszyn, M.3
  • 26
    • 1242276154 scopus 로고    scopus 로고
    • Synthesis and In Vitro Characterization of a Poly(Acrylic Acid)-Homocysteine Conjugate
    • DOI 10.1081/DDC-120027505
    • Bernkop-Schnurch A, Leitner V, Moser V. Synthesis and in vitro characterization of a poly(acrylic acid)-homocysteine conjugate. Drug Dev Ind Pharm 2004;30(1):1-8 (Pubitemid 38240470)
    • (2004) Drug Development and Industrial Pharmacy , vol.30 , Issue.1 , pp. 1-8
    • Bernkop-Schnurch, A.1    Leitner, V.2    Moser, V.3
  • 27
    • 0035962381 scopus 로고    scopus 로고
    • Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine
    • DOI 10.1016/S0168-3659(01)00227-9, PII S0168365901002279
    • Bernkop-Schnurch A, Kast CE, Richter MF. Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J Control Release 2001;71(3):277-85 (Pubitemid 32276047)
    • (2001) Journal of Controlled Release , vol.71 , Issue.3 , pp. 277-285
    • Bernkop-Schnurch, A.1    Kast, C.E.2    Richter, M.F.3
  • 28
    • 0033955625 scopus 로고    scopus 로고
    • Synthesis and characterisation of mucoadhesive thiolated polymers
    • DOI 10.1016/S0378-5173(99)00387-7, PII S0378517399003877
    • Bernkop-Schnurch A, Steininger S. Synthesis and characterisation of mucoadhesive thiolated polymers. Int J Pharm 2000;194(2):239-47 (Pubitemid 30110686)
    • (2000) International Journal of Pharmaceutics , vol.194 , Issue.2 , pp. 239-247
    • Bernkop-Schnurch, A.1    Steininger, S.2
  • 30
    • 80052886099 scopus 로고    scopus 로고
    • Synthesis of thiolated alginate and evaluation of mucoadhesiveness, cytotoxicity and release retardant properties
    • Jindal AB, Wasnik MN, Nair HA. Synthesis of thiolated alginate and evaluation of mucoadhesiveness, cytotoxicity and release retardant properties. Indian J Pharm Sci 2010;72(6):766-74
    • (2010) Indian J Pharm Sci , vol.72 , Issue.6 , pp. 766-774
    • Jindal, A.B.1    Wasnik, M.N.2    Nair, H.A.3
  • 31
    • 67349189475 scopus 로고    scopus 로고
    • Evaluating the mucoadhesive properties of drug delivery systems based on hydrated thiolated alginate
    • Davidovich-Pinhas M, Harari O, Bianco-Peled H. Evaluating the mucoadhesive properties of drug delivery systems based on hydrated thiolated alginate. J Control Release 2009;136(1):38-44
    • (2009) J Control Release , vol.136 , Issue.1 , pp. 38-44
    • Davidovich-Pinhas, M.1    Harari, O.2    Bianco-Peled, H.3
  • 32
    • 81255158081 scopus 로고    scopus 로고
    • Thiolated pectin nanoparticles: Preparation, characterization and ex vivo corneal permeation study
    • Sharma R, Ahuja M, Kaur H. Thiolated pectin nanoparticles: preparation, characterization and ex vivo corneal permeation study. Carbohydr Polym 2011;87:1606-10
    • (2011) Carbohydr Polym , vol.87 , pp. 1606-1610
    • Sharma, R.1    Ahuja, M.2    Kaur, H.3
  • 33
    • 84865347090 scopus 로고
    • Covalent coupling of unsaturated compounds to thiol agrarose using gamma-Radiation. A new method for preparation of adsorbents for affinity chromatography
    • Brandt J, Svenson A, Carlsson J, Drevin H. Covalent coupling of unsaturated compounds to thiol agrarose using gamma-Radiation. A new method for preparation of adsorbents for affinity chromatography. Appl Biochem Biotechnol 1977(2):2:109
    • (1977) Appl Biochem Biotechnol , vol.2 , Issue.2 , pp. 109
    • Brandt, J.1    Svenson, A.2    Carlsson, J.3    Drevin, H.4
  • 34
    • 0036229558 scopus 로고    scopus 로고
    • Thiolated polymers: Self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion
    • DOI 10.1016/S0928-0987(02)00025-8, PII S0928098702000258
    • Marschutz MK, Bernkop-Schnurch A. Thiolated polymers: self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Sci 2002;15(4):387-94 (Pubitemid 34436926)
    • (2002) European Journal of Pharmaceutical Sciences , vol.15 , Issue.4 , pp. 387-394
    • Marschutz, M.K.1    Bernkop-Schnurch, A.2
  • 35
    • 0033030493 scopus 로고    scopus 로고
    • Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II
    • DOI 10.1016/S0014-5793(98)01727-X, PII S001457939801727X
    • Burner U, Jantschko W, Obinger C. Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II. FEBS Lett 1999;443(3):290-6 (Pubitemid 29080813)
    • (1999) FEBS Letters , vol.443 , Issue.3 , pp. 290-296
    • Burner, U.1    Jantschko, W.2    Obinger, C.3
  • 37
    • 77949413865 scopus 로고    scopus 로고
    • Chitosan-4-mercaptobenzoic acid: Synthesis and characterization of a novel thiolated chitosan
    • Millotti G, Samberger C, Frohlich E, et al. Chitosan-4-mercaptobenzoic acid: synthesis and characterization of a novel thiolated chitosan. J Mater Chem 2010;20(12):2432-40
    • (2010) J Mater Chem , vol.20 , Issue.12 , pp. 2432-2440
    • Millotti, G.1    Samberger, C.2    Frohlich, E.3
  • 38
    • 77950918008 scopus 로고    scopus 로고
    • Hydrophobic thiolation of pectin with 4-aminothiophenol: Synthesis and in vitro characterization
    • Perera G, Hombach J, Bernkop-Schnurch A. Hydrophobic thiolation of pectin with 4-aminothiophenol: synthesis and in vitro characterization. AAPS PharmSciTech 2010;11(1):174-80
    • (2010) AAPS PharmSciTech , vol.11 , Issue.1 , pp. 174-180
    • Perera, G.1    Hombach, J.2    Bernkop-Schnurch, A.3
  • 39
    • 0018115212 scopus 로고
    • Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent
    • Carlsson J, Drevin H, Axen R. Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent. Biochem J 1978;173(3):723-37 (Pubitemid 9010965)
    • (1978) Biochemical Journal , vol.173 , Issue.3 , pp. 723-737
    • Carlsson, J.1    Drevin, H.2    Axen, R.3
  • 40
    • 0017123983 scopus 로고
    • A convenient method of preparation of high-activity urease from Canavalia ensiformis by covalent chromatography and an investigation of its thiol groups with 2, 2¢-dipyridyl disulphide as a thiol titrant and reactivity probe
    • Norris R, Brocklehurst K. A convenient method of preparation of high-activity urease from Canavalia ensiformis by covalent chromatography and an investigation of its thiol groups with 2, 2¢-dipyridyl disulphide as a thiol titrant and reactivity probe. Biochem J 1976;159(2):245-57
    • (1976) Biochem J , vol.159 , Issue.2 , pp. 245-257
    • Norris, R.1    Brocklehurst, K.2
  • 41
    • 83355177971 scopus 로고    scopus 로고
    • Preactivated thiomers as mucoadhesive polymers for drug delivery
    • Iqbal J, Shahnaz G, Dunnhaupt S, et al. Preactivated thiomers as mucoadhesive polymers for drug delivery. Biomaterials 2012;33(5):1528-35
    • (2012) Biomaterials , vol.33 , Issue.5 , pp. 1528-1535
    • Iqbal, J.1    Shahnaz, G.2    Dunnhaupt, S.3
  • 42
    • 37049176154 scopus 로고
    • Chemotherapeutic agents of the sulphone type; Effect of homologation on the antibacterial activity of p-methylsulphonyl-benzamidine and p-methylsulphonyl-benzylamine hydrochlorides
    • Forrest HS, Fuller AT, Walker J. Chemotherapeutic agents of the sulphone type; effect of homologation on the antibacterial activity of p-methylsulphonyl-benzamidine and p-methylsulphonyl-benzylamine hydrochlorides. J Chem Soc 1948;3:1501-6
    • (1948) J Chem Soc , vol.3 , pp. 1501-1506
    • Forrest, H.S.1    Fuller, A.T.2    Walker, J.3
  • 43
    • 84860749893 scopus 로고    scopus 로고
    • S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: Evaluation of permeation enhancing and efflux pump inhibitory properties
    • Dunnhaupt S, Barthelmes J, Rahmat D, et al. S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: evaluation of permeation enhancing and efflux pump inhibitory properties. Mol Pharm 2012;9(5):1331-41
    • (2012) Mol Pharm , vol.9 , Issue.5 , pp. 1331-1341
    • Dunnhaupt, S.1    Barthelmes, J.2    Rahmat, D.3
  • 44
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • DOI 10.1016/j.addr.2005.07.001, PII S0169409X05001390, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • Smart JD. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev 2005;57(11):1556-68 (Pubitemid 41443469)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1556-1568
    • Smart, J.D.1
  • 46
    • 0034925740 scopus 로고    scopus 로고
    • Thiolated polymers - thiomers: Development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    • DOI 10.1016/S0142-9612(00)00421-X, PII S014296120000421X
    • Kast CE, Bernkop-Schnurch A. Thiolated polymers-thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials 2001;22(17):2345-52 (Pubitemid 32666227)
    • (2001) Biomaterials , vol.22 , Issue.17 , pp. 2345-2352
    • Kast, C.E.1    Bernkop-Schnurch, A.2
  • 48
    • 79953242692 scopus 로고    scopus 로고
    • Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa
    • Dunnhaupt S, Barthelmes J, Hombach J, et al. Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa. Int J Pharm 2011;408(1-2):191-9
    • (2011) Int J Pharm , vol.408 , Issue.1-2 , pp. 191-199
    • Dunnhaupt, S.1    Barthelmes, J.2    Hombach, J.3
  • 49
    • 80051782861 scopus 로고    scopus 로고
    • Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder
    • Barthelmes J, Perera G, Hombach J, et al. Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder. Int J Pharm 2011;416(1):339-45
    • (2011) Int J Pharm , vol.416 , Issue.1 , pp. 339-345
    • Barthelmes, J.1    Perera, G.2    Hombach, J.3
  • 51
    • 84857617880 scopus 로고    scopus 로고
    • Absorption enhancers: Applications and advances
    • Aungst BJ. Absorption enhancers: applications and advances. The AAPS Journal 2012;14(1):10-18
    • (2012) The AAPS Journal , vol.14 , Issue.1 , pp. 10-18
    • Aungst, B.J.1
  • 52
    • 0030453145 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
    • DOI 10.1023/A:1016488623022
    • Luessen HL, de Leeuw BJ, Langemeyer MW, et al. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm Res 1996;13(11):1668-72 (Pubitemid 26426890)
    • (1996) Pharmaceutical Research , vol.13 , Issue.11 , pp. 1668-1672
    • Luessen, H.L.1    De Leeuw, B.J.2    Langemeyer, M.W.E.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 53
    • 33846876110 scopus 로고    scopus 로고
    • Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration
    • DOI 10.1016/j.ijpharm.2006.09.028, PII S0378517306007794
    • Werle M, Kafedjiiski K, Kolmar H, Bernkop-Schnurch A. Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration. Int J Pharm 2007;332(1-2):72-9 (Pubitemid 46227767)
    • (2007) International Journal of Pharmaceutics , vol.332 , Issue.1-2 , pp. 72-79
    • Werle, M.1    Kafedjiiski, K.2    Kolmar, H.3    Bernkop-Schnurch, A.4
  • 54
    • 0346735298 scopus 로고    scopus 로고
    • Thiolated chitosans: Development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system
    • DOI 10.1016/j.jconrel.2003.10.005
    • Bernkop-Schnurch A, Guggi D, Pinter Y. Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. J Control Release 2004;94(1):177-86 (Pubitemid 37542387)
    • (2004) Journal of Controlled Release , vol.94 , Issue.1 , pp. 177-186
    • Bernkop-Schnurch, A.1    Guggi, D.2    Pinter, Y.3
  • 55
    • 0036001390 scopus 로고    scopus 로고
    • The role of glutathione in the permeation enhancing effect of thiolated polymers
    • DOI 10.1023/A:1015345827091
    • Clausen AE, Kast CE, Bernkop-Schnurch A. The role of glutathione in the permeation enhancing effect of thiolated polymers. Pharm Res 2002;19(5):602-8 (Pubitemid 34553666)
    • (2002) Pharmaceutical Research , vol.19 , Issue.5 , pp. 602-608
    • Clausen, A.E.1    Kast, C.E.2    Bernkop-Schnurch, A.3
  • 56
    • 0018957830 scopus 로고
    • Metabolism of extracellular glutathione in rat small-intestinal mucosa
    • DOI 10.1111/j.1432-1033.1980.tb04605.x
    • Grafstrom R, Stead AH, Orrenius S. Metabolism of extracellular glutathione in rat small-intestinal mucosa. Eur J Biochem 1980;106(2):571-7 (Pubitemid 10025785)
    • (1980) European Journal of Biochemistry , vol.106 , Issue.2 , pp. 571-577
    • Grafstrom, R.1    Stead, A.H.2    Orrenius, S.3
  • 57
    • 0028931103 scopus 로고
    • Evidence that tyrosine phosphorylation may increase tight junction permeability
    • Staddon JM, Herrenknecht K, Smales C, Rubin LL. Evidence that tyrosine phosphorylation may increase tight junction permeability. J Cell Sci 1995;108(Pt 2):609-19
    • (1995) J Cell Sci , vol.108 , Issue.PART 2 , pp. 609-619
    • Staddon, J.M.1    Herrenknecht, K.2    Smales, C.3    Rubin, L.L.4
  • 59
    • 0033250545 scopus 로고    scopus 로고
    • Multidrug-resistance transporters
    • Silverman JA. Multidrug-resistance transporters. Pharm Biotechnol 1999;12:353-86
    • (1999) Pharm Biotechnol , vol.12 , pp. 353-386
    • Silverman, J.A.1
  • 60
    • 0042167430 scopus 로고    scopus 로고
    • P-glycoprotein inhibitors and their screening: A perspective from bioavailability enhancement
    • DOI 10.1016/S1043-6618(03)00158-0
    • Varma MV, Ashokraj Y, Dey CS, Panchagnula R. P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement. Pharmacol Res 2003;48(4):347-59 (Pubitemid 36945333)
    • (2003) Pharmacological Research , vol.48 , Issue.4 , pp. 347-359
    • Varma, M.V.S.1    Ashokraj, Y.2    Dey, C.S.3    Panchagnula, R.4
  • 61
    • 84860749893 scopus 로고    scopus 로고
    • S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: Evaluation of permeation enhancing and efflux pump inhibitory properties
    • Dunnhaupt S, Barthelmes J, Rahmat D, et al. S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: evaluation of permeation enhancing and efflux pump inhibitory properties. Mol Pharmaceutics 2012;9(5):pp 1331-1341
    • (2012) Mol Pharmaceutics , vol.9 , Issue.5 , pp. 1331-1341
    • Dunnhaupt, S.1    Barthelmes, J.2    Rahmat, D.3
  • 62
    • 75149183537 scopus 로고    scopus 로고
    • Chitosan-based delivery systems for protein therapeutics and antigens
    • Amidi M, Mastrobattista E, Jiskoot W, Hennink WE. Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev 2010;62(1):59-82
    • (2010) Adv Drug Deliv Rev , vol.62 , Issue.1 , pp. 59-82
    • Amidi, M.1    Mastrobattista, E.2    Jiskoot, W.3    Hennink, W.E.4
  • 63
    • 79953053491 scopus 로고    scopus 로고
    • The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery
    • Millotti G, Perera G, Vigl C, et al. The use of chitosan-6- mercaptonicotinic acid nanoparticles for oral peptide drug delivery. Drug Deliv 2011;18(3):190-7
    • (2011) Drug Deliv , vol.18 , Issue.3 , pp. 190-197
    • Millotti, G.1    Perera, G.2    Vigl, C.3
  • 64
    • 78649905059 scopus 로고    scopus 로고
    • The impact of vehicles on the mucoadhesive properties of orally administrated nanoparticles: A case study with chitosan-4-thiobutylamidine conjugate
    • Sakloetsakun D, Perera G, Hombach J, et al. The impact of vehicles on the mucoadhesive properties of orally administrated nanoparticles: a case study with chitosan-4-thiobutylamidine conjugate. AAPS PharmSciTech 2010;11(3):1185-92
    • (2010) AAPS PharmSciTech , vol.11 , Issue.3 , pp. 1185-1192
    • Sakloetsakun, D.1    Perera, G.2    Hombach, J.3
  • 65
    • 33646832739 scopus 로고    scopus 로고
    • Development of a novel method for the preparation of submicron particles based on thiolated chitosan
    • DOI 10.1016/j.ejpb.2006.01.002, PII S0939641106000117
    • Bernkop-Schnurch A, Heinrich A, Greimel A. Development of a novel method for the preparation of submicron particles based on thiolated chitosan. Eur J Pharm Biopharm 2006;63(2):166-72 (Pubitemid 43776219)
    • (2006) European Journal of Pharmaceutics and Biopharmaceutics , vol.63 , Issue.2 , pp. 166-172
    • Bernkop-Schnurch, A.1    Heinrich, A.2    Greimel, A.3
  • 66
  • 67
    • 70749108706 scopus 로고    scopus 로고
    • Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid)
    • Thaurer MH, Deutel B, Schlocker W, Bernkop-Schnurch A. Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid). J Microencapsul 2009;26(3):187-94
    • (2009) J Microencapsul , vol.26 , Issue.3 , pp. 187-194
    • Thaurer, M.H.1    Deutel, B.2    Schlocker, W.3    Bernkop-Schnurch, A.4
  • 69
    • 80055052515 scopus 로고    scopus 로고
    • What are parameters affecting Leu-enkephalin loading and release from poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan?
    • Mazzaferro S, Bouchemal K, Vauthier C, et al. What are parameters affecting Leu-enkephalin loading and release from poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan? J Drug Deliv Sci Technol 2011;21(5):385-93
    • (2011) J Drug Deliv Sci Technol , vol.21 , Issue.5 , pp. 385-393
    • Mazzaferro, S.1    Bouchemal, K.2    Vauthier, C.3
  • 70
    • 78049472974 scopus 로고    scopus 로고
    • Chitosan nanoparticles: A promising system in novel drug delivery
    • Nagpal K, Singh SK, Mishra DN. Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull (Tokyo) 2010;58(11):1423-30
    • (2010) Chem Pharm Bull (Tokyo) , vol.58 , Issue.11 , pp. 1423-1430
    • Nagpal, K.1    Singh, S.K.2    Mishra, D.N.3
  • 72
    • 7444268954 scopus 로고    scopus 로고
    • Recent advances on chitosan-based micro- and nanoparticles in drug delivery
    • DOI 10.1016/j.jconrel.2004.08.010, PII S0168365904003803
    • Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. J Control Release 2004;100(1):5-28 (Pubitemid 39445982)
    • (2004) Journal of Controlled Release , vol.100 , Issue.1 , pp. 5-28
    • Agnihotri, S.A.1    Mallikarjuna, N.N.2    Aminabhavi, T.M.3
  • 74
    • 68549122512 scopus 로고    scopus 로고
    • Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
    • Yin L, Ding J, He C, et al. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 2009;30(29):5691-700
    • (2009) Biomaterials , vol.30 , Issue.29 , pp. 5691-5700
    • Yin, L.1    Ding, J.2    He, C.3
  • 75
    • 70349329277 scopus 로고    scopus 로고
    • Insulin-loaded poly (acrylic acid)-cysteine nanoparticles: Stability studies towards digestive enzymes of the intestine
    • Perera G, Greindl M, Palmberger TF, Bernkop-Schnurch A. Insulin-loaded poly (acrylic acid)-cysteine nanoparticles: stability studies towards digestive enzymes of the intestine. Drug Deliv 2009;16(5):254-60
    • (2009) Drug Deliv , vol.16 , Issue.5 , pp. 254-260
    • Perera, G.1    Greindl, M.2    Palmberger, T.F.3    Bernkop-Schnurch, A.4
  • 76
    • 57749184307 scopus 로고    scopus 로고
    • A new approach to determine loading efficiency of Leu-enkephalin in poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan
    • Bouchemal K, Ponchell G, Mazzaferro S, et al. A new approach to determine loading efficiency of Leu-enkephalin in poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan. J Drug Deliv Sci Technol 2008;18(6):392-7
    • (2008) J Drug Deliv Sci Technol , vol.18 , Issue.6 , pp. 392-397
    • Bouchemal, K.1    Ponchell, G.2    Mazzaferro, S.3
  • 77
    • 65749116389 scopus 로고    scopus 로고
    • Encapsulation of leu-enkephalin in core-shell isobutylcyanoacrylate- thiolated chitosan nanoparticles for oral administratton
    • Requena V, Bouchemal K, Vauthier C, Ponchel G. Encapsulation of leu-enkephalin in core-shell isobutylcyanoacrylate-thiolated chitosan nanoparticles for oral administratton. J Chilean Chem Soc 2008;53(4):1677-81
    • (2008) J Chilean Chem Soc , vol.53 , Issue.4 , pp. 1677-1681
    • Requena, V.1    Bouchemal, K.2    Vauthier, C.3    Ponchel, G.4
  • 78
    • 84859429245 scopus 로고    scopus 로고
    • Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization
    • Shahnaz G, Vetter A, Barthelmes J, et al. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. Int J Pharm 2012;428(1-2):164-70
    • (2012) Int J Pharm , vol.428 , Issue.1-2 , pp. 164-170
    • Shahnaz, G.1    Vetter, A.2    Barthelmes, J.3
  • 79
    • 77955983828 scopus 로고    scopus 로고
    • Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin
    • Makhlof A, Werle M, Tozuka Y, Takeuchi H. Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin. Int J Pharm 2010;397(1-2):92-5
    • (2010) Int J Pharm , vol.397 , Issue.1-2 , pp. 92-95
    • Makhlof, A.1    Werle, M.2    Tozuka, Y.3    Takeuchi, H.4
  • 81
    • 27944507339 scopus 로고    scopus 로고
    • Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione
    • DOI 10.1021/bc050146t
    • Kommareddy S, Amiji M. Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione. Bioconjug Chem 2005;16(6):1423-32 (Pubitemid 41681508)
    • (2005) Bioconjugate Chemistry , vol.16 , Issue.6 , pp. 1423-1432
    • Kommareddy, S.1    Amiji, M.2
  • 83
    • 84455203030 scopus 로고    scopus 로고
    • Thiolated chitosan nanoparticles as a delivery system for antisense therapy: Evaluation against EGFR in T47D breast cancer cells
    • Talaei F, Azizi E, Dinarvand R, Atyabi F. Thiolated chitosan nanoparticles as a delivery system for antisense therapy: evaluation against EGFR in T47D breast cancer cells. Int J Nanomedicine 2011;6:1963-75
    • (2011) Int J Nanomedicine , vol.6 , pp. 1963-1975
    • Talaei, F.1    Azizi, E.2    Dinarvand, R.3    Atyabi, F.4
  • 86
    • 33750176860 scopus 로고    scopus 로고
    • Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system
    • DOI 10.1016/j.biomaterials.2006.08.017, PII S0142961206007186
    • Schmitz T, Bravo-Osuna I, Vauthier C, et al. Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system. Biomaterials 2007;28(3):524-31 (Pubitemid 44602224)
    • (2007) Biomaterials , vol.28 , Issue.3 , pp. 524-531
    • Schmitz, T.1    Bravo-Osuna, I.2    Vauthier, C.3    Ponchel, G.4    Loretz, B.5    Bernkop-Schnurch, A.6
  • 87
    • 34547235535 scopus 로고    scopus 로고
    • Role of sulfhydryl groups in transfection? A case study with chitosan-NAC nanoparticles
    • DOI 10.1021/bc0603079
    • Loretz B, Thaler M, Bernkop-Schnurch A. Role of sulfhydryl groups in transfection? A case study with chitosan-NAC nanoparticles. Bioconjug Chem 2007;18(4):1028-35 (Pubitemid 47122622)
    • (2007) Bioconjugate Chemistry , vol.18 , Issue.4 , pp. 1028-1035
    • Loretz, B.1    Thaler, M.2    Bernkop-Schnurch, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.