Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder

International Journal of Pharmaceutics

Volumn 416, Issue 1, 2011, Pages 339-345

  Barthelmes, Jan ^a   Perera, Glen ^a   Hombach, Juliane ^a   Dünnhaupt, Sarah ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Interstitial cystitis; Intravesical drug delivery system; Mucoadhesion; Nanoparticles; Sustained release preparation; Trimethoprim; Urinary bladder

Indexed keywords

CHITOSAN; CHITOSAN THIOGLYCOLIC ACID NANOPARTICLE; NANOPARTICLE; THIOGLYCOLIC ACID; TRIMETHOPRIM; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BLADDER; COVALENT BOND; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; FLOW RATE; GELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERSTITIAL CYSTITIS; INTESTINE MUCOSA; MICTURITION; MOLECULAR WEIGHT; MUCOADHESION; PARTICLE SIZE; PRIORITY JOURNAL;

ADHESIVES; ANIMALS; CHITOSAN; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; MUCOUS MEMBRANE; NANOPARTICLES; PARTICLE SIZE; POLYPHOSPHATES; SULFHYDRYL COMPOUNDS; SURFACE PROPERTIES; SWINE; THIOGLYCOLATES; TRIMETHOPRIM; URINARY BLADDER;

EID: 80051782861     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.06.033     Document Type: Article

References (31)

1. K. Albrecht, M. Greindl, C. Kremser, C. Wolf, P. Debbage, and A. Bernkop-Schnürch Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection J. Control. Release 115 2006 78 84 (Pubitemid 44415072)
2. K. Albrecht, E.J. Zirm, T.F. Palmberger, W. Schlocker, and A. Bernkop-Schnürch Preparation of thiomer microparticles and in vitro evaluation of parameters influencing their mucoadhesive properties Drug Dev. Ind. Pharm. 32 2006 1149 1157 (Pubitemid 44721729)
3. J.L. Au, S.H. Jang, and M.G. Wientjes Clinical aspects of drug delivery to tumors J. Control. Release 78 2002 81 95 (Pubitemid 34081855)
4. J.M. Barichello, M. Morishita, K. Takayama, and T. Nagai Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method Drug Dev. Ind. Pharm. 25 1999 471 476 (Pubitemid 29159426)
5. A. Bernkop-Schnürch Thiomers: a new generation of mucoadhesive polymers Adv. Drug Deliv. Rev. 57 2005 1569 1582 (Pubitemid 41443470)
6. A. Bernkop-Schnürch, A. Heinrich, and A. Greimel Development of a novel method for the preparation of submicron particles based on thiolated chitosan Eur. J. Pharm. Biopharm. 63 2006 166 172 (Pubitemid 43776219)
7. A. Bernkop-Schnürch, V. Schwarz, and S. Steininger Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm. Res. 16 1999 876 881 (Pubitemid 29284199)
8. A. Bernkop-Schnürch, and S. Steininger Synthesis and characterisation of mucoadhesive thiolated polymers Int. J. Pharm. 194 2000 239 247 (Pubitemid 30110686)
9. A. Bernkop-Schnürch, A. Weithaler, K. Albrecht, and A. Greimel Thiomers: preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system Int. J. Pharm. 317 2006 76 81 (Pubitemid 43866341)
10. A.K. Biswas, G.S. Rao, N. Kondaiah, A.S. Anjaneyulu, and J.K. Malik Simple multiresidue method for monitoring of trimethoprim and sulfonamide residues in buffalo meat by high-performance liquid chromatography J. Agric. Food Chem. 55 2007 8845 8850 (Pubitemid 350105526)
11. M. Bogataj, A. Mrhar, and L. Korosec Influence of physicochemical and biological parameters on drug release from microspheres adhered on vesical and intestinal mucosa Int. J. Pharm. 177 1999 211 220 (Pubitemid 29073416)
12. M. Burjak, M. Bogataj, M. Velnar, I. Grabnar, and A. Mrhar The study of drug release from microspheres adhered on pig vesical mucosa Int. J. Pharm. 224 2001 123 130 (Pubitemid 32706491)
13. S. Chutipongtanate, and V. Thongboonkerd Systematic comparisons of artificial urine formulas for in vitro cellular study Anal. Biochem. 402 2010 110 112
14. S. Dhawan, A.K. Singla, and V.R. Sinha Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods AAPS PharmSciTech 5 2004 e67
15. A. Domb, G.W.R. Davidson, and L.M. Sanders Diffusion of peptides through hydrogel membranes J. Control. Release 14 1990 133 144 (Pubitemid 20353563)
16. V. Grabovac, D. Guggi, and A. Bernkop-Schnürch Comparison of the mucoadhesive properties of various polymers Adv. Drug Deliv. Rev. 57 2005 1713 1723 (Pubitemid 41443475)
17. A. Greimel, M. Werle, and A. Bernkop-Schnürch Oral peptide delivery: in-vitro evaluation of thiolated alginate/poly(acrylic acid) microparticles J. Pharm. Pharmacol. 59 2007 1191 1198 (Pubitemid 47359897)
18. M. Greindl Oral Drug Delivery: Design and In Vitro/In Vivo Evaluation of Novel Permeation Enhancers and Efflux Inhibitors 2008 University of Innsbruck Innsbruck
19. R.L. Jackson, S.J. Busch, and A.D. Cardin Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes Physiol. Rev. 71 1991 481 539
20. M.K. Kos, M. Bogataj, and A. Mrhar Mucoadhesion on urinary bladder mucosa: the influence of sodium, calcium, and magnesium ions Pharmazie 65 1999 505 509
21. V.M. Leitner, G.F. Walker, and A. Bernkop-Schnürch Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins Eur. J. Pharm. Biopharm. 56 2003 207 214 (Pubitemid 37072104)
22. B.J. Levy, and T.N. Wight The role of proteoglycans in bladder structure and function Adv. Exp. Med. Biol. 385 1995 191 205 (discussion 223-8)
23. S.A. Lewis Everything you wanted to know about the bladder epithelium but were afraid to ask Am. J. Physiol. Renal Physiol. 278 2000 F867 F874
24. Y. Pan, Y.J. Li, H.Y. Zhao, J.M. Zheng, H. Xu, G. Wei, J.S. Hao, and F.D. Cui Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo Int. J. Pharm. 249 2002 139 147 (Pubitemid 35333440)
25. T. Schmitz, I. Bravo-Osuna, C. Vauthier, G. Ponchel, B. Loretz, and A. Bernkop-Schnürch Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system Biomaterials 28 2007 524 531 (Pubitemid 44602224)
26. R. Soler, H. Bruschini, J.R. Martins, J.L. Dreyfuss, N.O. Camara, M.T. Alves, K.R. Leite, J.C. Truzzi, H.B. Nader, M. Srougi, and V. Ortiz Urinary glycosaminoglycans as biomarker for urothelial injury: is it possible to discriminate damage from recovery? Urology 72 2008 937 942
27. P. Tyagi, S. Tyagi, J. Kaufman, L. Huang, and F. de Miguel Local drug delivery to bladder using technology innovations Urol. Clin. North Am. 33 2006 519 530 x
28. S.J. Warren, and I.W. Kellaway The synthesis and in vitro characterization of the mucoadhesion and swelling of poly(acrylic acid) hydrogels Pharm. Dev. Technol. 3 1998 199 208 (Pubitemid 28310935)
29. M. Werle, and M. Hoffer Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine J. Control. Release 111 2006 41 46 (Pubitemid 43289993)
30. W. Yang, J. Fu, T. Wang, and N. He Chitosan/sodium tripolyphosphate nanoparticles: preparation, characterization and application as drug carrier J. Biomed. Nanotechnol. 5 2009 591 595
31. H. Zhang, M. Oh, C. Allen, and E. Kumacheva Monodisperse chitosan nanoparticles for mucosal drug delivery Biomacromolecules 5 2004 2461 2468 (Pubitemid 39585302)