S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: Evaluation of permeation enhancing and efflux pump inhibitory properties

Molecular Pharmaceutics

Volumn 9, Issue 5, 2012, Pages 1331-1341

  Dünnhaupt, Sarah ^a   Barthelmes, Jan ^a   Rahmat, Deni ^a   Leithner, Katharina ^a   Thurner, Clemens C ^b   Friedl, Heike ^b   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Thiomatrix Forschungs und Beratungs GmbH   (Austria)

Author keywords

disulfide bonds; oral drug delivery; P gp inhibition; permeation enhancement; S protected thiomers; thiomers

Indexed keywords

6 MERCAPTONICOTINAMIDE; AROMATIC COMPOUND; CHITOSAN; CYANAMIDE; GLYCOPROTEIN P; POLYMER; RHODAMINE 123; THIOGLYCOLIC ACID; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CHEMICAL MODIFICATION; CONJUGATE; CONTROLLED STUDY; COVALENT BOND; DISULFIDE BOND; DRUG DELIVERY SYSTEM; EX VIVO STUDY; HYDROPHILICITY; IN VITRO STUDY; INTESTINE MUCOSA; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; RAT; TENSILE STRENGTH;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CHITOSAN; DRUG DELIVERY SYSTEMS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; P-GLYCOPROTEIN; RATS; THIOGLYCOLATES;

EID: 84860749893     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200598j     Document Type: Article

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