메뉴 건너뛰기




Volumn 27, Issue 11, 2009, Pages 628-635

Therapeutic application of peptides and proteins: parenteral forever?

Author keywords

[No Author keywords available]

Indexed keywords

BIODRUGS; BIOTECHNOLOGY INDUSTRY; DRUG DELIVERY SYSTEM; PATIENT COMPLIANCE; PHYSICOCHEMICAL PROPERTY; STABILIZING AGENTS; THERAPEUTIC APPLICATION; THERAPEUTIC PEPTIDES; TRANSDERMAL ADMINISTRATION;

EID: 70349998626     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2009.07.009     Document Type: Review
Times cited : (287)

References (70)
  • 1
    • 33746163862 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks 2006
    • Walsh G. Biopharmaceutical benchmarks 2006. Nat. Biotechnol. 24 (2006) 769-776
    • (2006) Nat. Biotechnol. , vol.24 , pp. 769-776
    • Walsh, G.1
  • 2
    • 33846304234 scopus 로고    scopus 로고
    • Bioleciva - jaky je jejich skutecny potencial?
    • Chrastilova Z., et al. Bioleciva - jaky je jejich skutecny potencial?. Chem. Listy 101 (2007) 25-35
    • (2007) Chem. Listy , vol.101 , pp. 25-35
    • Chrastilova, Z.1
  • 3
    • 30044449750 scopus 로고    scopus 로고
    • Protein therapeutics - lessons learned and a view of the future
    • Johnson-Léger C., et al. Protein therapeutics - lessons learned and a view of the future. Expert Opin. Biol. Ther. 6 (2006) 1-7
    • (2006) Expert Opin. Biol. Ther. , vol.6 , pp. 1-7
    • Johnson-Léger, C.1
  • 4
    • 40749145377 scopus 로고    scopus 로고
    • Properties and formulation of oral drug delivery systems of protein and peptides
    • Semalty A., et al. Properties and formulation of oral drug delivery systems of protein and peptides. Indian J. Pharm. Sci. 69 (2007) 741-747
    • (2007) Indian J. Pharm. Sci. , vol.69 , pp. 741-747
    • Semalty, A.1
  • 5
    • 52449102139 scopus 로고    scopus 로고
    • Past, present, and future technologies for oral delivery of therapeutic proteins
    • Singh R., et al. Past, present, and future technologies for oral delivery of therapeutic proteins. J. Pharm. Sci. 97 (2008) 2497-2523
    • (2008) J. Pharm. Sci. , vol.97 , pp. 2497-2523
    • Singh, R.1
  • 6
    • 0029357156 scopus 로고
    • Transdermal delivery of peptide and protein drugs: an overview
    • Amsden B.G., and Goosen F.A. Transdermal delivery of peptide and protein drugs: an overview. AIChE J. 41 (1995) 1972-1997
    • (1995) AIChE J. , vol.41 , pp. 1972-1997
    • Amsden, B.G.1    Goosen, F.A.2
  • 7
    • 40449091631 scopus 로고    scopus 로고
    • Novel approaches to enhance pulmonary delivery of proteins and peptides
    • Scheuch G., and Siekmeier R. Novel approaches to enhance pulmonary delivery of proteins and peptides. J. Physiol. Pharmacol. 58 (2007) 615-625
    • (2007) J. Physiol. Pharmacol. , vol.58 , pp. 615-625
    • Scheuch, G.1    Siekmeier, R.2
  • 8
    • 0022360381 scopus 로고
    • Controlled release of macromolecules: biological studies
    • Langer R., et al. Controlled release of macromolecules: biological studies. J. Cont. Rel. 2 (1985) 331-341
    • (1985) J. Cont. Rel. , vol.2 , pp. 331-341
    • Langer, R.1
  • 9
    • 0022917595 scopus 로고
    • Peptide and related drugs: A review of their absorption, metabolism and excretion
    • Humphrey M.J., and Ringrose P.S. Peptide and related drugs: A review of their absorption, metabolism and excretion. Drug. Metab. Rev. 17 (1986) 283-310
    • (1986) Drug. Metab. Rev. , vol.17 , pp. 283-310
    • Humphrey, M.J.1    Ringrose, P.S.2
  • 10
    • 0023370041 scopus 로고
    • Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity
    • McMartin C., et al. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J. Pharm. Sci. 76 (1987) 535-540
    • (1987) J. Pharm. Sci. , vol.76 , pp. 535-540
    • McMartin, C.1
  • 11
    • 0025029073 scopus 로고
    • Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption
    • Donovan M.D., et al. Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption. Pharm. Res. 7 (1990) 863-868
    • (1990) Pharm. Res. , vol.7 , pp. 863-868
    • Donovan, M.D.1
  • 12
    • 0027164091 scopus 로고
    • Formulation design of acidic fibroblast growth factor
    • Tsai P.K. Formulation design of acidic fibroblast growth factor. Pharm. Res. 10 (1993) 649-659
    • (1993) Pharm. Res. , vol.10 , pp. 649-659
    • Tsai, P.K.1
  • 13
    • 15844364250 scopus 로고    scopus 로고
    • A month-long effect from a single injection of microencapsulated human growth hormone
    • Johnson O.L., et al. A month-long effect from a single injection of microencapsulated human growth hormone. Nat. Med. 2 (1996) 795-799
    • (1996) Nat. Med. , vol.2 , pp. 795-799
    • Johnson, O.L.1
  • 14
    • 0027228385 scopus 로고
    • Techniques for assessing the effects of pharmaceutical recipients on aggregation of porcine growth hormone
    • Charman S.A., et al. Techniques for assessing the effects of pharmaceutical recipients on aggregation of porcine growth hormone. Pharm. Res. 10 (1993) 954-962
    • (1993) Pharm. Res. , vol.10 , pp. 954-962
    • Charman, S.A.1
  • 16
    • 0027982957 scopus 로고
    • Polymers for delivering peptides and proteins
    • Burnham N. Polymers for delivering peptides and proteins. Am. J. Hosp. Pharm. 51 (1994) 210-218
    • (1994) Am. J. Hosp. Pharm. , vol.51 , pp. 210-218
    • Burnham, N.1
  • 17
    • 47049099053 scopus 로고    scopus 로고
    • Multifunctional nanoparticles - properties and prospects for their use in human medicine
    • Sanvicens N., and Marco M.P. Multifunctional nanoparticles - properties and prospects for their use in human medicine. Trends Biotechnol. 26 (2008) 425-433
    • (2008) Trends Biotechnol. , vol.26 , pp. 425-433
    • Sanvicens, N.1    Marco, M.P.2
  • 18
    • 30444441465 scopus 로고    scopus 로고
    • The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis
    • Gelperina S., et al. The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. Am. J. Respir. Crit. Care Med. 172 (2005) 1487-1490
    • (2005) Am. J. Respir. Crit. Care Med. , vol.172 , pp. 1487-1490
    • Gelperina, S.1
  • 19
    • 0003062536 scopus 로고
    • Changing needs in drug delivery in the era of peptide and protein drugs
    • Lee V.H.L. (Ed), Marcel Dekker
    • Lee V.H.L. Changing needs in drug delivery in the era of peptide and protein drugs. In: Lee V.H.L. (Ed). Peptide and Protein Drug Delivery (1991), Marcel Dekker 1-56
    • (1991) Peptide and Protein Drug Delivery , pp. 1-56
    • Lee, V.H.L.1
  • 20
    • 0012020259 scopus 로고
    • Drug metabolism in the sk
    • advantages disadvantages., In: Hadgraft J., and Guy R.H. (Eds), Marcel Dekker
    • Tauber U. Drug metabolism in the sk. In: advantages disadvantages., In: Hadgraft J., and Guy R.H. (Eds). Transdermal Drug Delivery (1989), Marcel Dekker 99-112
    • (1989) Transdermal Drug Delivery , pp. 99-112
    • Tauber, U.1
  • 21
    • 0026650180 scopus 로고
    • The utility of a prodrug approach to improve peptide absorption
    • Bungaard H. The utility of a prodrug approach to improve peptide absorption. J. Control. Release 21 (1992) 63-72
    • (1992) J. Control. Release , vol.21 , pp. 63-72
    • Bungaard, H.1
  • 22
    • 0025597972 scopus 로고
    • Prodrugs of peptides. 7. Transdermal delivery of thyreotropin releasing hormone (TRH) via prodrugs
    • Møss J., and Bungaard H. Prodrugs of peptides. 7. Transdermal delivery of thyreotropin releasing hormone (TRH) via prodrugs. Int. J. Pharm 66 (1990) 39-45
    • (1990) Int. J. Pharm , vol.66 , pp. 39-45
    • Møss, J.1    Bungaard, H.2
  • 23
    • 0000804856 scopus 로고
    • Penetration enhancers and their use in transdermal therapeutic systems
    • Hadgraft J., and Guy R.H. (Eds), Marcel Dekker
    • Walters K.A. Penetration enhancers and their use in transdermal therapeutic systems. In: Hadgraft J., and Guy R.H. (Eds). Transdermal Drug Delivery (1989), Marcel Dekker 197-233
    • (1989) Transdermal Drug Delivery , pp. 197-233
    • Walters, K.A.1
  • 24
    • 0001923132 scopus 로고
    • Action of penetration enhancers of human stratum corneum as assessed by differential scanning calorimetry
    • Bronaugh R.L., and Maibach H.I. (Eds), Marcel Dekker
    • Goodman M., and Barry B.W. Action of penetration enhancers of human stratum corneum as assessed by differential scanning calorimetry. In: Bronaugh R.L., and Maibach H.I. (Eds). Percutaneous Absorption. 2nd edn (1989), Marcel Dekker 567-595
    • (1989) Percutaneous Absorption. 2nd edn , pp. 567-595
    • Goodman, M.1    Barry, B.W.2
  • 25
    • 0013898469 scopus 로고    scopus 로고
    • Topical absorption of polypeptides with dimethylsulfoxide
    • Kastin A.J., et al. Topical absorption of polypeptides with dimethylsulfoxide. Arch. Dermatol. 93 (1996) 471-473
    • (1996) Arch. Dermatol. , vol.93 , pp. 471-473
    • Kastin, A.J.1
  • 26
    • 0025953864 scopus 로고
    • Kinetics, ultrastructural aspects and molecular modelling of transdermal peptide flux enhancement by N-alkylazacycloheptanones
    • Hoogstraate A.J., et al. Kinetics, ultrastructural aspects and molecular modelling of transdermal peptide flux enhancement by N-alkylazacycloheptanones. Int. J. Pharm. 76 (1991) 37-47
    • (1991) Int. J. Pharm. , vol.76 , pp. 37-47
    • Hoogstraate, A.J.1
  • 27
    • 0025891212 scopus 로고
    • Transdermal delivery of insulin by ultrasonic vibration
    • Tachibana K., and Tachibana S. Transdermal delivery of insulin by ultrasonic vibration. J. Pharm. Pharmacol. 43 (1991) 270-271
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 270-271
    • Tachibana, K.1    Tachibana, S.2
  • 28
    • 84940921048 scopus 로고
    • Mechanisms of electroporation and electrofusion
    • Chang D.C., Saunders J.A., Chassy B.M., and Sowers A.E. (Eds), Academic Press
    • Sowers A.E. Mechanisms of electroporation and electrofusion. In: Chang D.C., Saunders J.A., Chassy B.M., and Sowers A.E. (Eds). Guide to Electroporation and Electrofusion (1992), Academic Press 119-138
    • (1992) Guide to Electroporation and Electrofusion , pp. 119-138
    • Sowers, A.E.1
  • 29
    • 0025346716 scopus 로고
    • Iontophoresis of polypeptides: effect of ethanol pretreatment of human skin
    • Srinivasan V., et al. Iontophoresis of polypeptides: effect of ethanol pretreatment of human skin. J. Pharm. Sci 79 (1990) 588-591
    • (1990) J. Pharm. Sci , vol.79 , pp. 588-591
    • Srinivasan, V.1
  • 30
    • 0025009164 scopus 로고
    • Transdermal versus subcutaneous leuprolide: a comparison of acute pharmacodynamic effect
    • Meyer B.R., et al. Transdermal versus subcutaneous leuprolide: a comparison of acute pharmacodynamic effect. Clin. Pharmacol. Ther. 48 (1990) 340-345
    • (1990) Clin. Pharmacol. Ther. , vol.48 , pp. 340-345
    • Meyer, B.R.1
  • 31
    • 0027178252 scopus 로고
    • Hydrogel-based iontotherapeutic delivery devices for transdermal delivery of peptide/protein drugs
    • Banga A.K., and Chien Y.W. Hydrogel-based iontotherapeutic delivery devices for transdermal delivery of peptide/protein drugs. Pharm. Res. 10 (1993) 697-702
    • (1993) Pharm. Res. , vol.10 , pp. 697-702
    • Banga, A.K.1    Chien, Y.W.2
  • 32
    • 0028881057 scopus 로고
    • Pulsatile transdermal delivery of LHRH using electroporation: drug delivery and skin toxicology
    • Riviere J.E., et al. Pulsatile transdermal delivery of LHRH using electroporation: drug delivery and skin toxicology. J. Control. Release 36 (1995) 229-233
    • (1995) J. Control. Release , vol.36 , pp. 229-233
    • Riviere, J.E.1
  • 33
    • 0024439651 scopus 로고
    • Transdermal peptide delivery
    • Boddé H.E., et al. Transdermal peptide delivery. Biochem. Soc. Trans. 17 (1989) 943-945
    • (1989) Biochem. Soc. Trans. , vol.17 , pp. 943-945
    • Boddé, H.E.1
  • 34
    • 0142214470 scopus 로고    scopus 로고
    • Evidence for lymphatic transport of insulin by topically applied biphasic vesicles
    • King M.J., et al. Evidence for lymphatic transport of insulin by topically applied biphasic vesicles. J. Pharm. Pharmacol. 55 (2003) 1339-1344
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 1339-1344
    • King, M.J.1
  • 35
    • 0032872359 scopus 로고    scopus 로고
    • Dermal and transdermal delivery of protein pharmaceuticals: lipid-based delivery systems for interferon alpha
    • Foldvari M., et al. Dermal and transdermal delivery of protein pharmaceuticals: lipid-based delivery systems for interferon alpha. Biotechnol. Appl. Biochem. 30 (1999) 129-137
    • (1999) Biotechnol. Appl. Biochem. , vol.30 , pp. 129-137
    • Foldvari, M.1
  • 36
    • 0028859518 scopus 로고
    • Delivery of biotherapeutics by inhalation aerosol
    • Niven R.V. Delivery of biotherapeutics by inhalation aerosol. Crit. Rev. Ther. Drug Carrier Syst. 12 (1995) 151-231
    • (1995) Crit. Rev. Ther. Drug Carrier Syst. , vol.12 , pp. 151-231
    • Niven, R.V.1
  • 37
    • 0031646537 scopus 로고    scopus 로고
    • Safety of inhaled proteins for therapeutic use
    • Wolff R.K. Safety of inhaled proteins for therapeutic use. J. Aerosol. Med. 11 (1998) 197-219
    • (1998) J. Aerosol. Med. , vol.11 , pp. 197-219
    • Wolff, R.K.1
  • 38
    • 0344513087 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications
    • Labiris N.R., and Dolovich M.B. Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications. J. Clin. Pharmacol 56 (2003) 588-599
    • (2003) J. Clin. Pharmacol , vol.56 , pp. 588-599
    • Labiris, N.R.1    Dolovich, M.B.2
  • 39
    • 0025094474 scopus 로고
    • Determinants of drug and polypetide bio-availability from aerosols delivered to the lung
    • Byron P.R. Determinants of drug and polypetide bio-availability from aerosols delivered to the lung. Adv. Drug Deliv Rev. 5 (1990) 107-132
    • (1990) Adv. Drug Deliv Rev. , vol.5 , pp. 107-132
    • Byron, P.R.1
  • 40
    • 0032869779 scopus 로고    scopus 로고
    • New propellant-free technologies under investigation
    • Dolovich M. New propellant-free technologies under investigation. J. Aerosol Med. 12 (1999) S9-S17
    • (1999) J. Aerosol Med. , vol.12
    • Dolovich, M.1
  • 41
    • 34848878587 scopus 로고    scopus 로고
    • ® Inhaled insulin system: a novel insulin-delivery system for patients with diabetes
    • ® Inhaled insulin system: a novel insulin-delivery system for patients with diabetes. Expert Rev. Med. Devices. 4 (2007) 683-692
    • (2007) Expert Rev. Med. Devices. , vol.4 , pp. 683-692
    • Rosenstock, J.1
  • 43
    • 34250719693 scopus 로고    scopus 로고
    • ® iDMS (Insulin Diabetes Management System) technology
    • ® iDMS (Insulin Diabetes Management System) technology. Diabetes Technol. Ther. 9 (2007) S57-S64
    • (2007) Diabetes Technol. Ther. , vol.9
    • Wollmer, P.1
  • 44
    • 0343417723 scopus 로고    scopus 로고
    • Inhalation therapy for growth hormone deficiency
    • Adjei J.A., and Gupta P.K. (Eds), Marcel Dekker
    • Wall D.A., and Smith P.L. Inhalation therapy for growth hormone deficiency. In: Adjei J.A., and Gupta P.K. (Eds). Inhalation Delivery of Therapeutic Peptides and proteins (1997), Marcel Dekker 453-473
    • (1997) Inhalation Delivery of Therapeutic Peptides and proteins , pp. 453-473
    • Wall, D.A.1    Smith, P.L.2
  • 45
    • 70349996143 scopus 로고
    • Amgen Inc. Pulmonary administration of erythropoietin,
    • U.S. Patent 5354934
    • Pitt, C.G. and Platz, R.M. (1994) Amgen Inc. Pulmonary administration of erythropoietin, U.S. Patent 5354934
    • (1994)
    • Pitt, C.G.1    Platz, R.M.2
  • 47
    • 34250907516 scopus 로고
    • Über die wirkung intratrachealer zuführung von insulin
    • Laqueur E., and Grevenstuk A. Über die wirkung intratrachealer zuführung von insulin. Klin. Wochenschr. 328 (1924) 1273-1274
    • (1924) Klin. Wochenschr. , vol.328 , pp. 1273-1274
    • Laqueur, E.1    Grevenstuk, A.2
  • 48
    • 34250940054 scopus 로고
    • Über inhalation von insulin
    • Heubner W., et al. Über inhalation von insulin. Klin. Wochenschr. 351 (1924) 2342-2343
    • (1924) Klin. Wochenschr. , vol.351 , pp. 2342-2343
    • Heubner, W.1
  • 49
    • 33745255214 scopus 로고
    • Über inhalation von insulin
    • Gänsslen M. Über inhalation von insulin. Klin. Wochenschr. 4 (1925) 71
    • (1925) Klin. Wochenschr. , vol.4 , pp. 71
    • Gänsslen, M.1
  • 50
    • 33748427226 scopus 로고    scopus 로고
    • Exhuberance over exhubera
    • Hite P.F., et al. Exhuberance over exhubera. Clin. Diabetes 24 (2006) 110-114
    • (2006) Clin. Diabetes , vol.24 , pp. 110-114
    • Hite, P.F.1
  • 51
    • 0035130249 scopus 로고    scopus 로고
    • The biopharmaceutical aspects of nasal mucoadhesive drug delivery
    • Ugwoke M.I., et al. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J. Pharm. Pharmacol. 53 (2001) 3-21
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 3-21
    • Ugwoke, M.I.1
  • 52
    • 70349997355 scopus 로고    scopus 로고
    • An overview on brain targeting drug delivery system
    • Shah S.H., et al. An overview on brain targeting drug delivery system. Pharm. Rev. (2009) 7
    • (2009) Pharm. Rev. , pp. 7
    • Shah, S.H.1
  • 53
    • 0037436997 scopus 로고    scopus 로고
    • Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats
    • Dufes C., et al. Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats. Int. J. Pharm. 255 (2003) 87-97
    • (2003) Int. J. Pharm. , vol.255 , pp. 87-97
    • Dufes, C.1
  • 54
    • 0242288486 scopus 로고    scopus 로고
    • Absorption enhancers for nasal drug delivery
    • David S.S., and Illum L. Absorption enhancers for nasal drug delivery. Clin. Pharmacokinet. 42 (2003) 1107-1128
    • (2003) Clin. Pharmacokinet. , vol.42 , pp. 1107-1128
    • David, S.S.1    Illum, L.2
  • 55
    • 3542998669 scopus 로고    scopus 로고
    • Nasal route and drug delivery systems
    • Türker S., et al. Nasal route and drug delivery systems. Pharm. World Sci. 26 (2004) 137-142
    • (2004) Pharm. World Sci. , vol.26 , pp. 137-142
    • Türker, S.1
  • 56
    • 70349999062 scopus 로고    scopus 로고
    • In vitro cellular models for nasal drug absorption studies
    • Ehrhardt C., and Kim K.-J. (Eds), Springer
    • Kim D.-D. In vitro cellular models for nasal drug absorption studies. In: Ehrhardt C., and Kim K.-J. (Eds). Drug Absorption Studies: In Situ, In Vitro and In Silico Models (2008), Springer 216-230
    • (2008) Drug Absorption Studies: In Situ, In Vitro and In Silico Models , pp. 216-230
    • Kim, D.-D.1
  • 57
    • 0023521756 scopus 로고
    • Experiences with Kryptocur in the treatment of cryptorchism
    • Vegh A. Experiences with Kryptocur in the treatment of cryptorchism. Acta Chir. Hung. 28 (1987) 257-261
    • (1987) Acta Chir. Hung. , vol.28 , pp. 257-261
    • Vegh, A.1
  • 58
    • 20944438677 scopus 로고    scopus 로고
    • Clinical outcome of salmon calcitonin nasal spray treatment in postmenopausal women after total hip arthroplasty
    • Peichl P., et al. Clinical outcome of salmon calcitonin nasal spray treatment in postmenopausal women after total hip arthroplasty. Gerontology 51 (2005) 242-252
    • (2005) Gerontology , vol.51 , pp. 242-252
    • Peichl, P.1
  • 59
    • 0030222256 scopus 로고    scopus 로고
    • Structural requirements for intestinal absorption of peptide dugs
    • Pauletti G., et al. Structural requirements for intestinal absorption of peptide dugs. J. Control. Release 41 (1996) 3-17
    • (1996) J. Control. Release , vol.41 , pp. 3-17
    • Pauletti, G.1
  • 60
    • 0028038011 scopus 로고
    • Enhanced oral absorption of insulin from desolvated fatty acid - sodium glycocholate emulsions
    • Mesiha M., et al. Enhanced oral absorption of insulin from desolvated fatty acid - sodium glycocholate emulsions. Int. J. Pharm. 111 (1994) 213-216
    • (1994) Int. J. Pharm. , vol.111 , pp. 213-216
    • Mesiha, M.1
  • 61
    • 0037027833 scopus 로고    scopus 로고
    • Positively charged nanoparticles for improving the oral bioavailability of ciclosporin-A
    • El-Shabouri M.H. Positively charged nanoparticles for improving the oral bioavailability of ciclosporin-A. Int. J. Pharm. 249 (2002) 101-108
    • (2002) Int. J. Pharm. , vol.249 , pp. 101-108
    • El-Shabouri, M.H.1
  • 62
    • 0022222411 scopus 로고
    • Recent developments in the design of angiotensin-converting enzyme inhibitors
    • Wyvratt M.J., and Patchett P.A. Recent developments in the design of angiotensin-converting enzyme inhibitors. Med. Res. Rev. 5 (1985) 483-531
    • (1985) Med. Res. Rev. , vol.5 , pp. 483-531
    • Wyvratt, M.J.1    Patchett, P.A.2
  • 63
    • 0019462747 scopus 로고
    • TRH degradation rates vary widely between different animal species
    • Brewster D., and Waltham K. TRH degradation rates vary widely between different animal species. Biochem. Pharmacol. 30 (1981) 619-622
    • (1981) Biochem. Pharmacol. , vol.30 , pp. 619-622
    • Brewster, D.1    Waltham, K.2
  • 64
    • 0019800071 scopus 로고
    • Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol
    • David S., et al. Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol. Clin. Exp. Immunol. 46 (1981) 649-652
    • (1981) Clin. Exp. Immunol. , vol.46 , pp. 649-652
    • David, S.1
  • 65
    • 0038390434 scopus 로고    scopus 로고
    • Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes
    • Kipnes M., et al. Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes. Diabetes Care 26 (2003) 421-426
    • (2003) Diabetes Care , vol.26 , pp. 421-426
    • Kipnes, M.1
  • 66
    • 0034601281 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?
    • Jung T., et al. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?. Eur. J. Pharm. Biopharm. 50 (2000) 147-160
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , pp. 147-160
    • Jung, T.1
  • 67
    • 21344466290 scopus 로고    scopus 로고
    • Double-coated poly(butylcynanoacrylate) nanoparticulate delivery systems for brain targeting of dalargin via oral administration
    • Das D., and Lin S. Double-coated poly(butylcynanoacrylate) nanoparticulate delivery systems for brain targeting of dalargin via oral administration. J. Pharm. Sci. 94 (2005) 1343-1353
    • (2005) J. Pharm. Sci. , vol.94 , pp. 1343-1353
    • Das, D.1    Lin, S.2
  • 68
    • 0036732080 scopus 로고    scopus 로고
    • Study on biodegradable microspheres containing recombinant interferon-alpha-2α
    • Zhou S., et al. Study on biodegradable microspheres containing recombinant interferon-alpha-2α. J. Pharm. Pharmacol. 54 (2002) 1287-1292
    • (2002) J. Pharm. Pharmacol. , vol.54 , pp. 1287-1292
    • Zhou, S.1
  • 69
    • 0031597891 scopus 로고    scopus 로고
    • Buccal mucosa as a route for systemic drug delivery: a review
    • Shojaei A.H. Buccal mucosa as a route for systemic drug delivery: a review. J. Pharm. Sci. 1 (1998) 15-30
    • (1998) J. Pharm. Sci. , vol.1 , pp. 15-30
    • Shojaei, A.H.1
  • 70
    • 0036022730 scopus 로고    scopus 로고
    • Liposome-mediated DNA vaccination by the oral route
    • Perrie Y., et al. Liposome-mediated DNA vaccination by the oral route. J. Liposome Res. 12 (2002) 185-197
    • (2002) J. Liposome Res. , vol.12 , pp. 185-197
    • Perrie, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.