Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: A novel correlational study design and bioinformatics approach in a graded chronic constriction injury model

Journal of Neurochemistry

Volumn 122, Issue 5, 2012, Pages 976-994

  Grace, Peter M ^a,b   Hurley, Daniel ^c,d   Barratt, Daniel T ^a   Tsykin, Anna ^e   Watkins, Linda R ^b   Rolan, Paul E ^a   Hutchinson, Mark R ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

^e CENTRE FOR CANCER BIOLOGY   (Australia)

Author keywords

allodynia; dorsal horn; Fc receptor; microarray; neuropathic pain; pathway analysis

Indexed keywords

FC RECEPTOR; IPSILATERAL LUMBAR DORSAL QUADRANT TRANSCRIPTOME; RNA; TRANSCRIPTOME; UNCLASSIFIED DRUG; WHOLE BLOOD TRANSCRIPTOME;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; BLOOD CHEMISTRY; CHRONIC CONSTRICTION INJURY; CHRONIC DISEASE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE MARKER; GENE; IMMUNE RESPONSE; IPSILATERAL LUMBAR DORSAL QUADRANT GENE; MALE; MARKER GENE; NERVE INJURY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; REPLICATION STUDY; SIGNAL TRANSDUCTION; VALIDATION STUDY;

ANIMALS; BIOLOGICAL MARKERS; COMPUTATIONAL BIOLOGY; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; HYPERALGESIA; LUMBOSACRAL REGION; MALE; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IGE; RECEPTORS, IGG; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SCIATICA; SIGNAL TRANSDUCTION; SPINAL CORD; STATISTICS AS TOPIC; TIME FACTORS; TRANSCRIPTOME;

RATTUS;

EID: 84865318200     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07833.x     Document Type: Article

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