Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28552-28563

  Tran, Hoanh ^a   Polakis, Paul ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYPOSIS COLI; CYTOSOLIC; HEK293 CELLS; HUMAN CANCER CELLS; OVER-EXPRESSION; POLYUBIQUITIN; POLYUBIQUITYLATION; TIME-DEPENDENT LOSS; TUMOR SUPPRESSORS; UBIQUITIN; WILD TYPES;

DEGRADATION; PHOSPHORYLATION;

CELL CULTURE;

APC PROTEIN; AXIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; LYSINE; MUTANT PROTEIN; POLYUBIQUITIN; WNT3A PROTEIN;

ARTICLE; CANCER CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOLIC FRACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA INTERFERENCE; UBIQUITINATION; WILD TYPE; WNT SIGNALING PATHWAY;

ADENOMATOUS POLYPOSIS COLI PROTEIN; AXIN PROTEIN; BETA CATENIN; CELL LINE, TUMOR; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; MULTIPROTEIN COMPLEXES; MUTATION; PROTEOLYSIS; UBIQUITINATION; WNT3A PROTEIN;

EID: 84865228580     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.387878     Document Type: Article

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