메뉴 건너뛰기




Volumn 82, Issue 3, 2012, Pages 529-540

Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; LUCIFERASE; MICRORNA; MICRORNA 103; MICRORNA 107; UNCLASSIFIED DRUG;

EID: 84865203418     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.078386     Document Type: Article
Times cited : (74)

References (60)
  • 1
    • 0038343499 scopus 로고    scopus 로고
    • MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing
    • Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113:673-676.
    • (2003) Cell , vol.113 , pp. 673-676
    • Ambros, V.1
  • 2
    • 0032818309 scopus 로고    scopus 로고
    • Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone
    • Baldwin SJ, Clarke SE, and Chenery RJ (1999) Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br J Clin Pharmacol 48:424-432.
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 424-432
    • Baldwin, S.J.1    Clarke, S.E.2    Chenery, R.J.3
  • 3
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 4
    • 0038299558 scopus 로고    scopus 로고
    • Role of microRNAs in plant and animal development
    • Carrington JC and Ambros V (2003) Role of microRNAs in plant and animal development. Science 301:336-338.
    • (2003) Science , vol.301 , pp. 336-338
    • Carrington, J.C.1    Ambros, V.2
  • 5
    • 0038650987 scopus 로고    scopus 로고
    • Nuclear receptor, pregnane X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16α- carbonitrile
    • Chen C, Staudinger JL, and Klaassen CD (2003a) Nuclear receptor, pregnane X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16α-carbonitrile. Drug Metab Dispos 31:908-915.
    • (2003) Drug Metab Dispos , vol.31 , pp. 908-915
    • Chen, C.1    Staudinger, J.L.2    Klaassen, C.D.3
  • 6
    • 0042844649 scopus 로고    scopus 로고
    • Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter
    • Chen Y, Ferguson SS, Negishi M, and Goldstein JA (2003b) Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol Pharmacol 64:316-324.
    • (2003) Mol Pharmacol , vol.64 , pp. 316-324
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 7
    • 1642498178 scopus 로고    scopus 로고
    • Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
    • Chen Y, Ferguson SS, Negishi M, and Goldstein JA (2004) Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther 308:495-501.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 495-501
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 8
    • 70450157394 scopus 로고    scopus 로고
    • The transcriptional regulation of the human CYP2C genes
    • Chen Y and Goldstein JA (2009) The transcriptional regulation of the human CYP2C genes. Curr Drug Metab 10:567-578.
    • (2009) Curr Drug Metab , vol.10 , pp. 567-578
    • Chen, Y.1    Goldstein, J.A.2
  • 12
    • 79551646708 scopus 로고    scopus 로고
    • Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice
    • Deng Y, Edin ML, Theken KN, Schuck RN, Flake GP, Kannon MA, DeGraff LM, Lih FB, Foley J, Bradbury JA, et al. (2011) Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J 25:703-713.
    • (2011) FASEB J , vol.25 , pp. 703-713
    • Deng, Y.1    Edin, M.L.2    Theken, K.N.3    Schuck, R.N.4    Flake, G.P.5    Kannon, M.A.6    DeGraff, L.M.7    Lih, F.B.8    Foley, J.9    Bradbury, J.A.10
  • 13
    • 80053919098 scopus 로고    scopus 로고
    • Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart
    • Edin ML, Wang Z, Bradbury JA, Graves JP, Lih FB, DeGraff LM, Foley JF, Torphy R, Ronnekleiv OK, Tomer KB, et al. (2011) Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart. FASEB J 25:3436-3447.
    • (2011) FASEB J , vol.25 , pp. 3436-3447
    • Edin, M.L.1    Wang, Z.2    Bradbury, J.A.3    Graves, J.P.4    Lih, F.B.5    DeGraff, L.M.6    Foley, J.F.7    Torphy, R.8    Ronnekleiv, O.K.9    Tomer, K.B.10
  • 14
    • 23944516070 scopus 로고    scopus 로고
    • Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4α
    • Ferguson SS, Chen Y, LeCluyse EL, Negishi M, and Goldstein JA (2005) Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4α. Mol Pharmacol 68:747-757.
    • (2005) Mol Pharmacol , vol.68 , pp. 747-757
    • Ferguson, S.S.1    Chen, Y.2    LeCluyse, E.L.3    Negishi, M.4    Goldstein, J.A.5
  • 15
    • 0036765751 scopus 로고    scopus 로고
    • Regulation of human CYP2C9 by the constitutive androstane receptor: Discovery of a new distal binding site
    • Ferguson SS, LeCluyse EL, Negishi M, and Goldstein JA (2002) Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol Pharmacol 62:737-746.
    • (2002) Mol Pharmacol , vol.62 , pp. 737-746
    • Ferguson, S.S.1    LeCluyse, E.L.2    Negishi, M.3    Goldstein, J.A.4
  • 16
    • 77956937207 scopus 로고    scopus 로고
    • The miR-15/107 group of microRNA genes: Evolutionary biology, cellular functions, and roles in human diseases
    • Finnerty JR, Wang WX, Hébert SS, Wilfred BR, Mao G, and Nelson PT (2010) The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases. J Mol Biol 402:491-509.
    • (2010) J Mol Biol , vol.402 , pp. 491-509
    • Finnerty, J.R.1    Wang, W.X.2    Hébert, S.S.3    Wilfred, B.R.4    Mao, G.5    Nelson, P.T.6
  • 19
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • Goldstein JA (2001) Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol 52:349-355.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 349-355
    • Goldstein, J.A.1
  • 20
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • Goldstein JA and de Morais SM (1994) Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 4:285-299.
    • (1994) Pharmacogenetics , vol.4 , pp. 285-299
    • Goldstein, J.A.1    De Morais, S.M.2
  • 22
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He L and Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5:522-531.
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 23
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Ingelman-Sundberg M, Sim SC, Gomez A, and Rodriguez-Antona C (2007) Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 116:496-526.
    • (2007) Pharmacol Ther , vol.116 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 24
    • 0028068016 scopus 로고
    • Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1
    • Inoue K, Inazawa J, Suzuki Y, Shimada T, Yamazaki H, Guengerich FP, and Abe T (1994) Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. Jpn J Hum Genet 39:337-343.
    • (1994) Jpn J Hum Genet , vol.39 , pp. 337-343
    • Inoue, K.1    Inazawa, J.2    Suzuki, Y.3    Shimada, T.4    Yamazaki, H.5    Guengerich, F.P.6    Abe, T.7
  • 25
    • 57349134379 scopus 로고    scopus 로고
    • Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Kalscheuer S, Zhang X, Zeng Y, and Upadhyaya P (2008) Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino) -1-(3-pyridyl)-1-butanone. Carcinogenesis 29:2394-2399.
    • (2008) Carcinogenesis , vol.29 , pp. 2394-2399
    • Kalscheuer, S.1    Zhang, X.2    Zeng, Y.3    Upadhyaya, P.4
  • 26
    • 0032604625 scopus 로고    scopus 로고
    • Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs
    • Klose TS, Blaisdell JA, and Goldstein JA (1999) Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J Biochem Mol Toxicol 13:289-295.
    • (1999) J Biochem Mol Toxicol , vol.13 , pp. 289-295
    • Klose, T.S.1    Blaisdell, J.A.2    Goldstein, J.A.3
  • 27
    • 70349333224 scopus 로고    scopus 로고
    • Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b
    • Komagata S, Nakajima M, Takagi S, Mohri T, Taniya T, and Yokoi T (2009) Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b. Mol Pharmacol 76:702-709.
    • (2009) Mol Pharmacol , vol.76 , pp. 702-709
    • Komagata, S.1    Nakajima, M.2    Takagi, S.3    Mohri, T.4    Taniya, T.5    Yokoi, T.6
  • 28
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, and Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 29
    • 1642446616 scopus 로고    scopus 로고
    • Investigation of enzyme selectivity in the human CYP2C subfamily: Homology modelling of CYP2C8, CYP2C9 and CYP2C19 from the CYP2C5 crystallographic template
    • Lewis DF, Dickins M, Lake BG, and Goldfarb PS (2003) Investigation of enzyme selectivity in the human CYP2C subfamily: homology modelling of CYP2C8, CYP2C9 and CYP2C19 from the CYP2C5 crystallographic template. Drug Metabol Drug Interact 19:257-285.
    • (2003) Drug Metabol Drug Interact , vol.19 , pp. 257-285
    • Lewis, D.F.1    Dickins, M.2    Lake, B.G.3    Goldfarb, P.S.4
  • 30
    • 0036154008 scopus 로고    scopus 로고
    • Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: A new high affinity and turnover enzyme-specific probe substrate
    • Li XQ, Björkman A, Andersson TB, Ridderström M, and Masimirembwa CM (2002) Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther 300:399-407.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 399-407
    • Li, X.Q.1    Björkman, A.2    Andersson, T.B.3    Ridderström, M.4    Masimirembwa, C.M.5
  • 31
    • 0032520750 scopus 로고    scopus 로고
    • Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain
    • McFayden MC, Melvin WT, and Murray GI (1998) Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain. Biochem Pharmacol 55:825-830.
    • (1998) Biochem Pharmacol , vol.55 , pp. 825-830
    • McFayden, M.C.1    Melvin, W.T.2    Murray, G.I.3
  • 34
    • 79960113406 scopus 로고    scopus 로고
    • MicroRNAs from biology to future pharmacotherapy: Regulation of cytochrome P450s and nuclear receptors
    • Nakajima M and Yokoi T (2011) MicroRNAs from biology to future pharmacotherapy: regulation of cytochrome P450s and nuclear receptors. Pharmacol Ther 131:330-337.
    • (2011) Pharmacol Ther , vol.131 , pp. 330-337
    • Nakajima, M.1    Yokoi, T.2
  • 35
    • 0041922374 scopus 로고    scopus 로고
    • Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR
    • Nishimura M, Yaguti H, Yoshitsugu H, Naito S, and Satoh T (2003) Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi 123:369-375.
    • (2003) Yakugaku Zasshi , vol.123 , pp. 369-375
    • Nishimura, M.1    Yaguti, H.2    Yoshitsugu, H.3    Naito, S.4    Satoh, T.5
  • 36
    • 29944446317 scopus 로고    scopus 로고
    • Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: Implications for drug-drug interactions
    • Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, and Parkinson A (2006) Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos 34:191-197.
    • (2006) Drug Metab Dispos , vol.34 , pp. 191-197
    • Ogilvie, B.W.1    Zhang, D.2    Li, W.3    Rodrigues, A.D.4    Gipson, A.E.5    Holsapple, J.6    Toren, P.7    Parkinson, A.8
  • 37
    • 0033783019 scopus 로고    scopus 로고
    • A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: An approach to predict the contribution with relative activity factor
    • Ohyama K, Nakajima M, Nakamura S, Shimada N, Yamazaki H, and Yokoi T (2000) A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos 28:1303-1310.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1303-1310
    • Ohyama, K.1    Nakajima, M.2    Nakamura, S.3    Shimada, N.4    Yamazaki, H.5    Yokoi, T.6
  • 38
    • 0026456664 scopus 로고
    • Post-transcriptional regulation of mouse renal cytochrome P450 2E1 by testosterone
    • Pan J, Hong JY, and Yang CS (1992) Post-transcriptional regulation of mouse renal cytochrome P450 2E1 by testosterone. Arch Biochem Biophys 299:110-115.
    • (1992) Arch Biochem Biophys , vol.299 , pp. 110-115
    • Pan, J.1    Hong, J.Y.2    Yang, C.S.3
  • 39
    • 70349268327 scopus 로고    scopus 로고
    • MicroRNAs regulate CYP3A4 expression via direct and indirect targeting
    • Pan YZ, Gao W, and Yu AM (2009) MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab Dispos 37:2112-2117.
    • (2009) Drug Metab Dispos , vol.37 , pp. 2112-2117
    • Pan, Y.Z.1    Gao, W.2    Yu, A.M.3
  • 40
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi JM, Drocourt L, Fabre JM, Maurel P, and Vilarem MJ (2000a) Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 58:361-372.
    • (2000) Mol Pharmacol , vol.58 , pp. 361-372
    • Pascussi, J.M.1    Drocourt, L.2    Fabre, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 41
    • 0033664347 scopus 로고    scopus 로고
    • Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: Consequences on cytochrome P450 gene regulation
    • Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, and Vilarem MJ (2000b) Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol Pharmacol 58:1441-1450.
    • (2000) Mol Pharmacol , vol.58 , pp. 1441-1450
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Fabre, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 42
    • 0028036727 scopus 로고
    • Selective biotransformation of Taxol to 6α-hydroxytaxol by human cytochrome P450 2C8
    • Rahman A, Korzekwa KR, Grogan J, Gonzalez FJ, and Harris JW (1994) Selective biotransformation of Taxol to 6α-hydroxytaxol by human cytochrome P450 2C8. Cancer Res 54:5543-5546.
    • (1994) Cancer Res , vol.54 , pp. 5543-5546
    • Rahman, A.1    Korzekwa, K.R.2    Grogan, J.3    Gonzalez, F.J.4    Harris, J.W.5
  • 43
    • 77950278579 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes
    • Rana R, Chen Y, Ferguson SS, Kissling GE, Surapureddi S, and Goldstein JA (2010) Hepatocyte nuclear factor 4α regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes. Drug Metab Dispos 38:591-599.
    • (2010) Drug Metab Dispos , vol.38 , pp. 591-599
    • Rana, R.1    Chen, Y.2    Ferguson, S.S.3    Kissling, G.E.4    Surapureddi, S.5    Goldstein, J.A.6
  • 44
    • 78751558863 scopus 로고    scopus 로고
    • Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver
    • Rana R, Surapureddi S, Kam W, Ferguson S, and Goldstein JA (2011) Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. Mol Cell Biol 31:466-481.
    • (2011) Mol Cell Biol , vol.31 , pp. 466-481
    • Rana, R.1    Surapureddi, S.2    Kam, W.3    Ferguson, S.4    Goldstein, J.A.5
  • 45
    • 0036784511 scopus 로고    scopus 로고
    • A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system
    • Raucy J, Warfe L, Yueh MF, and Allen SW (2002) A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. J Pharmacol Exp Ther 303:412-423.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 412-423
    • Raucy, J.1    Warfe, L.2    Yueh, M.F.3    Allen, S.W.4
  • 46
    • 0037790717 scopus 로고    scopus 로고
    • Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity
    • Sempere LF, Sokol NS, Dubrovsky EB, Berger EM, and Ambros V (2003) Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity. Dev Biol 259:9-18.
    • (2003) Dev Biol , vol.259 , pp. 9-18
    • Sempere, L.F.1    Sokol, N.S.2    Dubrovsky, E.B.3    Berger, E.M.4    Ambros, V.5
  • 47
    • 77956812311 scopus 로고    scopus 로고
    • A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes
    • Song KH, Li T, Owsley E, and Chiang JY (2010) A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes. J Lipid Res 51:2223-2233.
    • (2010) J Lipid Res , vol.51 , pp. 2223-2233
    • Song, K.H.1    Li, T.2    Owsley, E.3    Chiang, J.Y.4
  • 48
    • 79955468688 scopus 로고    scopus 로고
    • NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes
    • Surapureddi S, Rana R, and Goldstein JA (2011) NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. Pharmacol Res 63:405-413.
    • (2011) Pharmacol Res , vol.63 , pp. 405-413
    • Surapureddi, S.1    Rana, R.2    Goldstein, J.A.3
  • 49
    • 77951157723 scopus 로고    scopus 로고
    • MicroRNAs regulate human hepatocyte nuclear factor 4α, modulating the expression of metabolic enzymes and cell cycle
    • Takagi S, Nakajima M, Kida K, Yamaura Y, Fukami T, and Yokoi T (2010) MicroRNAs regulate human hepatocyte nuclear factor 4α, modulating the expression of metabolic enzymes and cell cycle. J Biol Chem 285:4415-4422.
    • (2010) J Biol Chem , vol.285 , pp. 4415-4422
    • Takagi, S.1    Nakajima, M.2    Kida, K.3    Yamaura, Y.4    Fukami, T.5    Yokoi, T.6
  • 50
    • 44349182094 scopus 로고    scopus 로고
    • Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4
    • Takagi S, Nakajima M, Mohri T, and Yokoi T (2008) Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J Biol Chem 283:9674-9680.
    • (2008) J Biol Chem , vol.283 , pp. 9674-9680
    • Takagi, S.1    Nakajima, M.2    Mohri, T.3    Yokoi, T.4
  • 51
    • 19144368324 scopus 로고    scopus 로고
    • Cytochrome P450 2C8: Substrates, inhibitors, pharmacogenetics, and clinical relevance
    • Totah RA and Rettie AE (2005) Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance. Clin Pharmacol Ther 77:341-352.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 341-352
    • Totah, R.A.1    Rettie, A.E.2
  • 52
    • 0032897280 scopus 로고    scopus 로고
    • Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil
    • Tracy TS, Korzekwa KR, Gonzalez FJ, and Wainer IW (1999) Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. Br J Clin Pharmacol 47:545-552.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 545-552
    • Tracy, T.S.1    Korzekwa, K.R.2    Gonzalez, F.J.3    Wainer, I.W.4
  • 55
    • 33749487425 scopus 로고    scopus 로고
    • MicroRNA regulates the expression of human cytochrome P450 1B1
    • Tsuchiya Y, Nakajima M, Takagi S, Taniya T, and Yokoi T (2006) MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res 66:9090-9098.
    • (2006) Cancer Res , vol.66 , pp. 9090-9098
    • Tsuchiya, Y.1    Nakajima, M.2    Takagi, S.3    Taniya, T.4    Yokoi, T.5
  • 56
    • 0036892714 scopus 로고    scopus 로고
    • Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes
    • Wang JS, Neuvonen M, Wen X, Backman JT, and Neuvonen PJ (2002) Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos 30:1352-1356.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1352-1356
    • Wang, J.S.1    Neuvonen, M.2    Wen, X.3    Backman, J.T.4    Neuvonen, P.J.5
  • 57
    • 15244358503 scopus 로고    scopus 로고
    • Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
    • Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, and Kellis M (2005) Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 434:338-345.
    • (2005) Nature , vol.434 , pp. 338-345
    • Xie, X.1    Lu, J.2    Kulbokas, E.J.3    Golub, T.R.4    Mootha, V.5    Lindblad-Toh, K.6    Lander, E.S.7    Kellis, M.8
  • 58
    • 0032725398 scopus 로고    scopus 로고
    • Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes
    • Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, and Yokoi T (1999) Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab Dispos 27:1260-1266.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1260-1266
    • Yamazaki, H.1    Shibata, A.2    Suzuki, M.3    Nakajima, M.4    Shimada, N.5    Guengerich, F.P.6    Yokoi, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.