An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity

Genome Research

Volumn 20, Issue 1, 2010, Pages 28-35

  Liu, Hong Hsing ^a   Lu, Peng ^a   Guo, Yingying ^a   Farrell, Erin ^a   Zhang, Xun ^a   Zheng, Ming ^b   Bosano, Betty ^b   Zhang, Zhaomei ^a   Allard, John ^a   Liao, Guochun ^a   Fu, Siyu ^a   Chen, Jinzhi ^a   Dolim, Kimberly ^b   Kuroda, Ayako ^b   Usuka, Jonathan ^b   Cheng, Janet ^a   Tao, William ^b   Welch, Kevin ^c   Liu, Yanzhou ^d   Pease, Joseph ^d   De Keczer, Steve A ^d   Masjedizadeh, Mohammad ^d   Hu, Jing Shan ^a   Weller, Paul ^b   Garrow, Tim ^e   Peltz, Gary ^f   more..

^a Roche Palo Alto ^*  (United States)

^b Non Clinical Safety   (United States)

^c Roche Palo Alto   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^f STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE HOMOCYSTEINE METHYLTRANSFERASE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE 2; GLUTATHIONE; METHIONINE; PARACETAMOL; S METHYLMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG INDUCED DISEASE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOME ANALYSIS; HEREDITY; IN VIVO CULTURE; INBRED STRAIN; KNOWLEDGE BASE; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLOMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; DIET; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION PROFILING; LIVER; LIVER FAILURE, ACUTE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SEQUENCE ANALYSIS, DNA; VITAMIN U;

MUS;

EID: 74949107162     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.097212.109     Document Type: Article

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