Diabetic KK-Ay mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 2, 2010, Pages

  Kon, Kazuyoshi ^a   Ikejima, Kenichi ^a,b   Okumura, Kyoko ^a   Arai, Kumiko ^a   Aoyama, Tomonori ^a,b   Watanabe, Sumio ^a,b  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Drug induced liver injury; Hepatotoxicity; Metabolic syndrome; Oxidative stress; Steatohepatitis

Indexed keywords

4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; COLLAGENASE; DICHLORODIHYDROFLUORESCEIN DIACETATE; GLUTATHIONE; PARACETAMOL; PROPIDIUM IODIDE; PROTEIN C JUN; TERT BUTYL HYDROPEROXIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL DEATH; CELL ISOLATION; CONTROLLED STUDY; DIABETIC KK A GAMMA MOUSE; ENZYME PHOSPHORYLATION; EXPERIMENTAL MOUSE; FATTY LIVER; FLUOROMETRY; IMMUNOHISTOCHEMISTRY; LIVER CELL DAMAGE; LIVER HISTOLOGY; LIVER INJURY; LIVER TOXICITY; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPECTROPHOTOMETRY; TISSUE PERFUSION; WESTERN BLOTTING;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CELL DEATH; DIABETES COMPLICATIONS; DIABETES MELLITUS; DISEASE SUSCEPTIBILITY; DRUG-INDUCED LIVER INJURY; ENZYME ACTIVATION; HEPATOCYTES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OXIDATIVE STRESS;

EID: 77955643841     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00361.2009     Document Type: Article

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