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Volumn 90, Issue 7, 2012, Pages 735-745

Human induced pluripotent stem cells-from mechanisms to clinical applications

Author keywords

Applications; ESCs; Human embryonic stem cells; Human induced pluripotent stem cells; IPSCs; Mechanisms

Indexed keywords

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; PROTEIN LIN28; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

EID: 84865142720     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0913-0     Document Type: Review
Times cited : (49)

References (130)
  • 1
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147 (Pubitemid 28516247)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1145-1147
    • Thomson, J.A.1
  • 2
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872 (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 5
    • 79954989303 scopus 로고    scopus 로고
    • A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells
    • Wang Y, Adjaye J (2011) A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev 7:331-341
    • (2011) Stem Cell Rev , vol.7 , pp. 331-341
    • Wang, Y.1    Adjaye, J.2
  • 9
    • 79952305054 scopus 로고    scopus 로고
    • Efficient feeder-free episomal reprogramming with small molecules
    • Yu J, Chau KF, Vodyanik MA, Jiang J, Jiang Y (2011) Efficient feeder-free episomal reprogramming with small molecules. PLoS One 6:e17557
    • (2011) PLoS One , vol.6
    • Yu, J.1    Chau, K.F.2    Vodyanik, M.A.3    Jiang, J.4    Jiang, Y.5
  • 12
    • 64749111225 scopus 로고    scopus 로고
    • Virus-free induction of pluripotency and subsequent excision of reprogramming factors
    • Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P,Woltjen K (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458:771-775
    • (2009) Nature , vol.458 , pp. 771-775
    • Kaji, K.1    Norrby, K.2    Paca, A.3    Mileikovsky, M.4    Mohseni, P.5    Woltjen, K.6
  • 13
    • 77958082207 scopus 로고    scopus 로고
    • Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette
    • Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BWet al (2010) Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells 28:1728-1740
    • (2010) Stem Cells , vol.28 , pp. 1728-1740
    • Somers, A.1    Jean, J.C.2    Sommer, C.A.3    Omari, A.4    Ford, C.C.5    Mills, J.A.6    Ying, L.7    Sommer, A.G.8    Jean, J.M.9    Bwet Al, S.10
  • 15
    • 72849137462 scopus 로고    scopus 로고
    • Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells
    • Zhou W, Freed CR (2009) Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells 27:2667-2674
    • (2009) Stem Cells , vol.27 , pp. 2667-2674
    • Zhou, W.1    Freed, C.R.2
  • 16
    • 70450265981 scopus 로고    scopus 로고
    • Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
    • Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M (2009) Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci 85:348-362
    • (2009) Proc Jpn Acad ser B Phys Biol Sci , vol.85 , pp. 348-362
    • Fusaki, N.1    Ban, H.2    Nishiyama, A.3    Saeki, K.4    Hasegawa, M.5
  • 17
    • 77955118962 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors
    • Si-Tayeb K, Noto FK, Sepac A, Sedlic F, Bosnjak ZJ, Lough JW, Duncan SA (2010) Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. BMC Dev Biol 10:81
    • (2010) BMC Dev Biol , vol.10 , pp. 81
    • Si-Tayeb, K.1    Noto, F.K.2    Sepac, A.3    Sedlic, F.4    Bosnjak, Z.J.5    Lough, J.W.6    Duncan, S.A.7
  • 24
    • 84858795607 scopus 로고    scopus 로고
    • The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts
    • Drews K, Tavernier G, Demeester J, Lehrach H, De Smedt SC, Rejman J, Adjaye J (2012) The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts. Biomaterials 33(16):4059-4068
    • (2012) Biomaterials , vol.33 , Issue.16 , pp. 4059-4068
    • Drews, K.1    Tavernier, G.2    Demeester, J.3    Lehrach, H.4    De Smedt, S.C.5    Rejman, J.6    Adjaye, J.7
  • 25
    • 70350380887 scopus 로고    scopus 로고
    • Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells
    • Utikal J, Maherali N, Kulalert W, Hochedlinger K (2009) Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci 122:3502-3510
    • (2009) J Cell Sci , vol.122 , pp. 3502-3510
    • Utikal, J.1    Maherali, N.2    Kulalert, W.3    Hochedlinger, K.4
  • 26
    • 79952536226 scopus 로고    scopus 로고
    • Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures
    • Chou BK, Mali P, Huang X, Ye Z, Dowey SN, Resar LM, Zou C, Zhang YA, Tong J, Cheng L (2011) Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res 21:518-529
    • (2011) Cell Res , vol.21 , pp. 518-529
    • Chou, B.K.1    Mali, P.2    Huang, X.3    Ye, Z.4    Dowey, S.N.5    Resar, L.M.6    Zou, C.7    Zhang, Y.A.8    Tong, J.9    Cheng, L.10
  • 28
    • 78650977507 scopus 로고    scopus 로고
    • Direct generation of induced pluripotent stem cells from human nonmobilized blood
    • Kunisato A, Wakatsuki M, Shinba H, Ota T, Ishida I, Nagao K (2011) Direct generation of induced pluripotent stem cells from human nonmobilized blood. Stem Cells Dev 20:159-168
    • (2011) Stem Cells Dev , vol.20 , pp. 159-168
    • Kunisato, A.1    Wakatsuki, M.2    Shinba, H.3    Ota, T.4    Ishida, I.5    Nagao, K.6
  • 32
    • 70350672576 scopus 로고    scopus 로고
    • Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells
    • Li C, Zhou J, Shi G, Ma Y, Yang Y, Gu J, Yu H, Jin S, Wei Z, Chen F et al (2009) Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells. Hum Mol Genet 18:4340-4349
    • (2009) Hum Mol Genet , vol.18 , pp. 4340-4349
    • Li, C.1    Zhou, J.2    Shi, G.3    Ma, Y.4    Yang, Y.5    Gu, J.6    Yu, H.7    Jin, S.8    Wei, Z.9    Chen, F.10
  • 33
    • 78149442366 scopus 로고    scopus 로고
    • The LARGE principle of cellular reprogramming: Lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells
    • Wolfrum K, Wang Y, Prigione A, Sperling K, Lehrach H, Adjaye J (2010) The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells. PLoS One 5:e13703
    • (2010) PLoS One , vol.5
    • Wolfrum, K.1    Wang, Y.2    Prigione, A.3    Sperling, K.4    Lehrach, H.5    Adjaye, J.6
  • 34
    • 67649880603 scopus 로고    scopus 로고
    • Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases
    • Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW (2009) Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A 106:9826-9830
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9826-9830
    • Ye, L.1    Chang, J.C.2    Lin, C.3    Sun, X.4    Yu, J.5    Kan, Y.W.6
  • 35
    • 33846917472 scopus 로고    scopus 로고
    • Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
    • DOI 10.1634/stemcells.2006-0426
    • Babaie Y, Herwig R, Greber B, Brink TC, Wruck W, Groth D, Lehrach H, Burdon T, Adjaye J (2007) Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells 25:500-510 (Pubitemid 46232806)
    • (2007) Stem Cells , vol.25 , Issue.2 , pp. 500-510
    • Babaie, Y.1    Herwig, R.2    Greber, B.3    Brink, T.C.4    Wruck, W.5    Groth, D.6    Lehrach, H.7    Burdon, T.8    Adjaye, J.9
  • 37
    • 77956269672 scopus 로고    scopus 로고
    • A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells
    • Jung M, Peterson H, Chavez L, Kahlem P, Lehrach H, Vilo J, Adjaye J (2010) A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells. PLoS One 5:e10709
    • (2010) PLoS One , vol.5
    • Jung, M.1    Peterson, H.2    Chavez, L.3    Kahlem, P.4    Lehrach, H.5    Vilo, J.6    Adjaye, J.7
  • 45
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q et al (2010) A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7:51-63
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3    Zhou, T.4    Qing, X.5    Li, H.6    He, W.7    Chen, J.8    Li, F.9    Zhuang, Q.10
  • 46
    • 79955755007 scopus 로고    scopus 로고
    • MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-toepithelial transition
    • Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B et al (2011) MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-toepithelial transition. J Biol Chem 286:17359-17364
    • (2011) J Biol Chem , vol.286 , pp. 17359-17364
    • Liao, B.1    Bao, X.2    Liu, L.3    Feng, S.4    Zovoilis, A.5    Liu, W.6    Xue, Y.7    Cai, J.8    Guo, X.9    Qin, B.10
  • 48
    • 37049007672 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition events during human embryonic stem cell differentiation
    • DOI 10.1158/0008-5472.CAN-07-2253
    • Eastham AM, Spencer H, Soncin F, Ritson S, Merry CL, Stern PL, Ward CM (2007) Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res 67:11254-11262 (Pubitemid 350248551)
    • (2007) Cancer Research , vol.67 , Issue.23 , pp. 11254-11262
    • Eastham, A.M.1    Spencer, H.2    Soncin, F.3    Ritson, S.4    Merry, C.L.R.5    Stern, P.L.6    Ward, C.M.7
  • 50
    • 8644286440 scopus 로고    scopus 로고
    • Presence of functional gap junctions in human embryonic stem cells
    • Wong RC, Pebay A, Nguyen LT, Koh KL, Pera MF (2004) Presence of functional gap junctions in human embryonic stem cells. Stem Cells 22:883-889 (Pubitemid 39507076)
    • (2004) Stem Cells , vol.22 , Issue.6 , pp. 883-889
    • Wong, R.C.B.1    Pebay, A.2    Nguyen, L.T.V.3    Koh, K.L.L.4    Pera, M.F.5
  • 51
    • 83455218560 scopus 로고    scopus 로고
    • Global epigenetic changes during somatic cell reprogramming to iPS cells
    • Mattout A, Biran A, Meshorer E (2011) Global epigenetic changes during somatic cell reprogramming to iPS cells. J Mol Cell Biol 3:341-350
    • (2011) J Mol Cell Biol , vol.3 , pp. 341-350
    • Mattout, A.1    Biran, A.2    Meshorer, E.3
  • 52
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu PP, Sabatini DM (2008) Cancer cell metabolism: Warburg and beyond. Cell 134:703-707
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 53
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O (1956) On the origin of cancer cells. Science 123:309-314
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 54
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 55
    • 77951002352 scopus 로고    scopus 로고
    • The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
    • Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J (2010) The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells 28:721-733
    • (2010) Stem Cells , vol.28 , pp. 721-733
    • Prigione, A.1    Fauler, B.2    Lurz, R.3    Lehrach, H.4    Adjaye, J.5
  • 56
    • 80052015415 scopus 로고    scopus 로고
    • Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming
    • Prigione A, Lichtner B, Kuhl H, Struys EA,Wamelink M, Lehrach H, Ralser M, Timmermann B, Adjaye J (2011) Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming. Stem Cells 29(9):1338-1348
    • (2011) Stem Cells , vol.29 , Issue.9 , pp. 1338-1348
    • Prigione, A.1    Lichtner, B.2    Kuhl, H.3    Struys, E.A.4    Wamelink, M.5    Lehrach, H.6    Ralser, M.7    Timmermann, B.8    Adjaye, J.9
  • 57
    • 77951021307 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells
    • Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M (2010) Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells. Stem Cells 28:661-673
    • (2010) Stem Cells , vol.28 , pp. 661-673
    • Armstrong, L.1    Tilgner, K.2    Saretzki, G.3    Atkinson, S.P.4    Stojkovic, M.5    Moreno, R.6    Przyborski, S.7    Lako, M.8
  • 65
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    • Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ et al (2011) Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 8:106-118
    • (2011) Cell Stem Cell , vol.8 , pp. 106-118
    • Laurent, L.C.1    Ulitsky, I.2    Slavin, I.3    Tran, H.4    Schork, A.5    Morey, R.6    Lynch, C.7    Harness, J.V.8    Lee, S.9    Barrero, M.J.10
  • 71
    • 79952261648 scopus 로고    scopus 로고
    • Stem cells: The dark side of induced pluripotency
    • Pera MF (2011) Stem cells: the dark side of induced pluripotency. Nature 471:46-47
    • (2011) Nature , vol.471 , pp. 46-47
    • Pera, M.F.1
  • 76
    • 77957325592 scopus 로고    scopus 로고
    • Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells
    • Ghosh Z,Wilson KD,Wu Y, Hu S, Quertermous T,Wu JC (2010) Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One 5:e8975
    • (2010) PLoS One , vol.5
    • Ghosh, Z.1    Wilson, K.D.2    Wu, Y.3    Hu, S.4    Quertermous, T.5    Wu, J.C.6
  • 77
    • 78649874029 scopus 로고    scopus 로고
    • Memory in induced pluripotent stem cells: Reprogrammed human retinalpigmented epithelial cells show tendency for spontaneous redifferentiation
    • Hu Q, Friedrich AM, Johnson LV, Clegg DO (2010) Memory in induced pluripotent stem cells: reprogrammed human retinalpigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells 28:1981-1991
    • (2010) Stem Cells , vol.28 , pp. 1981-1991
    • Hu, Q.1    Friedrich, A.M.2    Johnson, L.V.3    Clegg, D.O.4
  • 81
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR (2010) A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143:527-539
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6    Chen, G.7    Gage, F.H.8    Muotri, A.R.9
  • 83
    • 0036301269 scopus 로고    scopus 로고
    • Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: Molecular mechanisms that determine lower expression in cultured cells
    • DOI 10.1080/00498250210128675
    • Rodriguez-Antona C, Donato MT, Boobis A, Edwards RJ, Watts PS, Castell JV, Gomez-Lechon MJ (2002) Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Xenobiotica 32:505-520 (Pubitemid 34743622)
    • (2002) Xenobiotica , vol.32 , Issue.6 , pp. 505-520
    • Rodriguez-Antona, C.1    Donato, M.T.2    Boobis, A.3    Edwards, R.J.4    Watts, P.S.5    Castell, J.V.6    Gomez-Lechon, M.-J.7
  • 84
    • 0042904900 scopus 로고    scopus 로고
    • Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties
    • DOI 10.1124/dmd.31.8.1035
    • Wilkening S, Stahl F, Bader A (2003) Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metab Dispos 31:1035-1042 (Pubitemid 36975674)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.8 , pp. 1035-1042
    • Wilkening, S.1    Stahl, F.2    Bader, A.3
  • 85
    • 84859418689 scopus 로고    scopus 로고
    • Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat
    • Carpenter L, Carr C, Yang CT, Stuckey DJ, Clarke K, Watt SM (2012) Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells Dev 21(6):977-986
    • (2012) Stem Cells Dev , vol.21 , Issue.6 , pp. 977-986
    • Carpenter, L.1    Carr, C.2    Yang, C.T.3    Stuckey, D.J.4    Clarke, K.5    Watt, S.M.6
  • 86
    • 79251554060 scopus 로고    scopus 로고
    • Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models
    • Dambrot C, Passier R, Atsma D, Mummery CL (2011) Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models. Biochem J 434:25-35
    • (2011) Biochem J , vol.434 , pp. 25-35
    • Dambrot, C.1    Passier, R.2    Atsma, D.3    Mummery, C.L.4
  • 87
    • 77956370269 scopus 로고    scopus 로고
    • From skin cells to hepatocytes: Advances in application of iPS cell technology
    • Greenbaum LE (2010) From skin cells to hepatocytes: advances in application of iPS cell technology. J Clin Invest 120:3102-3105
    • (2010) J Clin Invest , vol.120 , pp. 3102-3105
    • Greenbaum, L.E.1
  • 88
    • 79959820846 scopus 로고    scopus 로고
    • Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
    • Jozefczuk J, Prigione A, Chavez L, Adjaye J (2011) Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation. Stem Cells Dev 20:1259-1275
    • (2011) Stem Cells Dev , vol.20 , pp. 1259-1275
    • Jozefczuk, J.1    Prigione, A.2    Chavez, L.3    Adjaye, J.4
  • 94
    • 46949093825 scopus 로고    scopus 로고
    • HLA-haplotype banking and iPS cells
    • DOI 10.1038/nbt0708-739, PII NBT0708739
    • Nakatsuji N, Nakajima F, Tokunaga K (2008) HLA-haplotype banking and iPS cells. Nat Biotechnol 26:739-740 (Pubitemid 351961440)
    • (2008) Nature Biotechnology , vol.26 , Issue.7 , pp. 739-740
    • Nakatsuji, N.1    Nakajima, F.2    Tokunaga, K.3
  • 95
    • 63049090064 scopus 로고    scopus 로고
    • A fresh look at iPS cells
    • Yamanaka S (2009) A fresh look at iPS cells. Cell 137:13-17
    • (2009) Cell , vol.137 , pp. 13-17
    • Yamanaka, S.1
  • 96
    • 77957565227 scopus 로고    scopus 로고
    • Stimulating progress in regenerative medicine: Improving the cloning and recovery of cryopreserved human pluripotent stem cells with ROCK inhibitors
    • Rizzino A (2010) Stimulating progress in regenerative medicine: improving the cloning and recovery of cryopreserved human pluripotent stem cells with ROCK inhibitors. Regen Med 5:799-807
    • (2010) Regen Med , vol.5 , pp. 799-807
    • Rizzino, A.1
  • 97
    • 84455208080 scopus 로고    scopus 로고
    • Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells
    • Ichikawa H, Nakata N, Abo Y, Shirasawa S, Yokoyama T, Yoshie S, Yue F, Tomotsune D, Sasaki K (2012) Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells. Cryobiology 64:12-22
    • (2012) Cryobiology , vol.64 , pp. 12-22
    • Ichikawa, H.1    Nakata, N.2    Abo, Y.3    Shirasawa, S.4    Yokoyama, T.5    Yoshie, S.6    Yue, F.7    Tomotsune, D.8    Sasaki, K.9
  • 98
    • 61449223659 scopus 로고    scopus 로고
    • ROCK inhibitor improves survival of cryopreserved serum/feeder-free single human embryonic stem cells
    • Li X, Krawetz R, Liu S, Meng G, Rancourt DE (2009) ROCK inhibitor improves survival of cryopreserved serum/feeder-free single human embryonic stem cells. Hum Reprod (Oxford, England) 24:580-589
    • (2009) Hum Reprod (Oxford, England) , vol.24 , pp. 580-589
    • Li, X.1    Krawetz, R.2    Liu, S.3    Meng, G.4    Rancourt, D.E.5
  • 104
    • 79952788665 scopus 로고    scopus 로고
    • A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs
    • Salvagiotto G, Burton S, Daigh CA, Rajesh D, Slukvin II, Seay NJ (2011) A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs. PLoS One 6:e17829
    • (2011) PLoS One , vol.6
    • Salvagiotto, G.1    Burton, S.2    Daigh, C.A.3    Rajesh, D.4    Slukvin, I.I.5    Seay, N.J.6
  • 105
    • 84859017992 scopus 로고    scopus 로고
    • Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection Biological Sciences: Applied Biological Sciences
    • Whitemarsh R, Strathman M, Chase L, Stankewicz C, Tepp W, Johnson E, Pellett S (2012) Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection Biological Sciences: Applied Biological Sciences. Toxicol Sci 126(2):426-435
    • (2012) Toxicol Sci , vol.126 , Issue.2 , pp. 426-435
    • Whitemarsh, R.1    Strathman, M.2    Chase, L.3    Stankewicz, C.4    Tepp, W.5    Johnson, E.6    Pellett, S.7
  • 106
    • 77957670482 scopus 로고    scopus 로고
    • Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats
    • doi:10.1073/pnas.1010209107
    • Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ et al (2010) Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A 107:15921-15926. doi:10.1073/pnas.1010209107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15921-15926
    • Hargus, G.1    Cooper, O.2    Deleidi, M.3    Levy, A.4    Lee, K.5    Marlow, E.6    Yow, A.7    Soldner, F.8    Hockemeyer, D.9    Hallett, P.J.10
  • 108
    • 61349100729 scopus 로고    scopus 로고
    • Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    • doi:10.1016/j.cell.2009.02.013
    • Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M et al (2009) Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136:964-977. doi:10.1016/j.cell.2009.02.013
    • (2009) Cell , vol.136 , pp. 964-977
    • Soldner, F.1    Hockemeyer, D.2    Beard, C.3    Gao, Q.4    Bell, G.W.5    Cook, E.G.6    Hargus, G.7    Blak, A.8    Cooper, O.9    Mitalipova, M.10
  • 109
    • 78149302874 scopus 로고    scopus 로고
    • Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions
    • doi:10.1002/stem.499
    • Swistowski A, Peng J, Liu Q, Mali P, Rao MS, Cheng L, Zeng X (2010) Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells 28:1893-1904. doi:10.1002/stem.499
    • (2010) Stem Cells , vol.28 , pp. 1893-1904
    • Swistowski, A.1    Peng, J.2    Liu, Q.3    Mali, P.4    Rao, M.S.5    Cheng, L.6    Zeng, X.7
  • 112
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • doi:10.1016/j.cell.2010.10.016
    • Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR (2010) A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143:527-539. doi:10.1016/j.cell.2010.10.016
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6    Chen, G.7    Gage, F.H.8    Muotri, A.R.9
  • 113
    • 80052246984 scopus 로고    scopus 로고
    • Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells
    • doi:10.1093/hmg/ddr285
    • Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D (2011) Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells. Hum Mol Genet 20:3653-3666. doi:10.1093/hmg/ddr285
    • (2011) Hum Mol Genet , vol.20 , pp. 3653-3666
    • Lemonnier, T.1    Blanchard, S.2    Toli, D.3    Roy, E.4    Bigou, S.5    Froissart, R.6    Rouvet, I.7    Vitry, S.8    Heard, J.M.9    Bohl, D.10
  • 124
    • 84863230167 scopus 로고    scopus 로고
    • The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity
    • doi:10.1016/j.nbd.2011.12.042
    • Camnasio S, Carri AD, Lombardo A, Grad I, Mariotti C, Castucci A, Rozell B, Riso PL, Castiglioni V, Zuccato C et al (2012) The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity. Neurobiol Dis 46:41-51. doi:10.1016/j.nbd.2011.12.042
    • (2012) Neurobiol Dis , vol.46 , pp. 41-51
    • Camnasio, S.1    Carri, A.D.2    Lombardo, A.3    Grad, I.4    Mariotti, C.5    Castucci, A.6    Rozell, B.7    Riso, P.L.8    Castiglioni, V.9    Zuccato, C.10
  • 125
    • 77957347780 scopus 로고    scopus 로고
    • Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells
    • doi:10.1007/s12015-010-9189-3
    • Ghodsizadeh A, Taei A, Totonchi M, Seifinejad A, Gourabi H, Pournasr B, Aghdami N, Malekzadeh R, Almadani N, Salekdeh GH et al (2010) Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells. Stem Cell Rev 6:622-632. doi:10.1007/s12015-010-9189-3
    • (2010) Stem Cell Rev , vol.6 , pp. 622-632
    • Ghodsizadeh, A.1    Taei, A.2    Totonchi, M.3    Seifinejad, A.4    Gourabi, H.5    Pournasr, B.6    Aghdami, N.7    Malekzadeh, R.8    Almadani, N.9    Salekdeh, G.H.10
  • 126
    • 79960831061 scopus 로고    scopus 로고
    • Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin
    • doi:10.1093/hmg/ddr223
    • Zhang S, Chen S, LiW, Guo X, Zhao P, Xu J, Chen Y, Pan Q, Liu X, Zychlinski D et al (2011) Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Hum Mol Genet 20:3176-3187. doi:10.1093/hmg/ddr223
    • (2011) Hum Mol Genet , vol.20 , pp. 3176-3187
    • Zhang, S.1    Chen, S.2    Li, W.3    Guo, X.4    Zhao, P.5    Xu, J.6    Chen, Y.7    Pan, Q.8    Liu, X.9    Zychlinski, D.10
  • 129
    • 79960060773 scopus 로고    scopus 로고
    • Modelling familial dysautonomia in human induced pluripotent stem cells
    • doi:10.1098/rstb.2011.0026
    • Lee G, Studer L (2011) Modelling familial dysautonomia in human induced pluripotent stem cells. Philos Trans R Soc Lond B Biol Sci 366:2286-2296. doi:10.1098/rstb.2011.0026
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , pp. 2286-2296
    • Lee, G.1    Studer, L.2


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