A Cyclic AMP Analog, 8-Br-cAMP, Enhances the Induction of Pluripotency in Human Fibroblast Cells

Stem Cell Reviews and Reports

Volumn 7, Issue 2, 2011, Pages 331-341

  Wang, Ying ^a   Adjaye, James ^a,b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

8 Br cAMP; Cell cycle; Embryonic stem cells; Induced pluripotent stem cells; p53; Pluripotency; VPA

Indexed keywords

8 BROMO CYCLIC AMP; HOMEODOMAIN PROTEIN; NANOG PROTEIN, HUMAN; PROTEIN P53; TP53 PROTEIN, HUMAN; VALPROIC ACID;

ANIMAL; ARTICLE; CELL CULTURE; CELL DEDIFFERENTIATION; COCULTURE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; KARYOTYPING; MALE; METABOLISM; MOUSE; MOUSE MUTANT; PLURIPOTENT STEM CELL;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CELL DEDIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KARYOTYPING; MALE; MICE; MICE, SCID; TUMOR SUPPRESSOR PROTEIN P53; VALPROIC ACID;

IPS;

EID: 79954989303     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-010-9209-3     Document Type: Article

References (40)

1. Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663-676.
2. Meissner, A., Wernig, M., & Jaenisch, R. (2007). Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol, 25(10), 1177-1181.
3. Takahashi, K., Tanabe, K., Ohnuki, M., et al. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861-872.
4. Yu, J., Vodyanik, M. A., Smuga-Otto, K., et al. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858), 1917-1920.
5. Dimos, J. T., Rodolfa, K. T., Niakan, K. K., et al. (2008). Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science, 321(5893), 1218-1221.
6. Park, I. H., Arora, N., Huo, H., et al. (2008). Disease-specific induced pluripotent stem cells. Cell, 134(5), 877-886.
7. Ebert, A. D., Yu, J., Rose, F. F., Jr., et al. (2009). Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature, 457(7227), 277-280.
8. Soldner, F., Hockemeyer, D., Beard, C., et al. (2009). Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell, 136(5), 964-977.
9. Raya, A., Rodríguez-Pizà, I., Guenechea, G., et al. (2009). Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature, 460(7251), 53-59.
10. Song, Z., Cai, J., Liu, Y., et al. (2009). Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res, 19(11), 1233-1242.
11. Si-Tayeb, K., Noto, F. K., Nagaoka, M., et al. (2010). Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology, 51(1), 297-305.
12. Sullivan, G. J., Hay, D. C., Park, I. H., et al. (2010). Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology, 51(1), 329-335.
13. Zhang, J., Wilson, G. F., Soerens, A. G., et al. (2009). Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res, 104(4), e30-e41.
14. Zhang, D., Jiang, W., Liu, M., et al. (2009). Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res, 19(4), 429-438.
15. Choi, K. D., Yu, J., Smuga-Otto, K., et al. (2009). Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells, 27(3), 559-567.
16. Taura, D., Noguchi, M., Sone, M., et al. (2009). Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Lett, 583(6), 1029-1033.
17. Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol, 27(3), 275-280.
18. Mikkelsen, T. S., Hanna, J., Zhang, X., et al. (2008). Dissecting direct reprogramming through integrative genomic analysis. Nature, 454(7200), 49-55.
19. Huangfu, D., Maehr, R., Guo, W., et al. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol, 26(7), 795-797.
20. Shi, Y., Desponts, C., Do, J. T., Hahm, H. S., Schöler, H. R., & Ding, S. (2008). Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell, 3(5), 568-574.
21. Shi, Y., Do, J. T., Desponts, C., Hahm, H. S., Schöler, H. R., & Ding, S. (2008). A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell, 2(6), 525-528.
22. Esteban, M. A., Wang, T., Qin, B., et al. (2010). Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 6(1), 71-79.
23. Wang, Y., Mah, N., Prigione, A., Wolfrum, K., Andrade-Navarro, M. A., & Adjaye, J. (2010). A transcriptional roadmap to the induction of pluripotency in somatic cells. Stem Cell Rev, 6(2), 282-296.
24. Huangfu, D., Osafune, K., Maehr, R., et al. (2008). Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol, 26(11), 1269-1275.
25. Lin, T., Ambasudhan, R., Yuan, X., et al. (2009). A chemical platform for improved induction of human iPSCs. Nat Methods, 6(11), 805-808.
26. Babaie, Y., Herwig, R., Greber, B., et al. (2007). Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells, 25(2), 500-510.
27. Zhao, Y., Yin, X., Qin, H., et al. (2008). Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell, 3(5), 475-479.
28. Hong, H., Takahashi, K., Ichisaka, T., et al. (2009). Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature, 460(7259), 1132-1135.
29. Li, H., Collado, M., Villasante, A., et al. (2009). The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature, 460(7259), 1136-1139.
30. Kawamura, T., Suzuki, J., Wang, Y. V., et al. (2009). Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature, 460(7259), 1140-1144.
31. Utikal, J., Polo, J. M., Stadtfeld, M., et al. (2009). Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature, 460(7259), 1145-1148.
32. Marión, R. M., Strati, K., Li, H., et al. (2009). A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature, 460(7259), 1149-1153.
33. Park, I. H., Zhao, R., West, J. A., et al. (2008). Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 451(7175), 141-146.
34. Prigione, A., Fauler, B., Lurz, R., Lehrach, H., & Adjaye, J. (2010). The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells, 28(4), 721-733.
35. Ogreid, D., Ekanger, R., Suva, R. H., Miller, J. P., & Døskeland, S. O. (1989). Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs. Eur J Biochem, 181(1), 19-31.
36. Chen, T. C., Hinton, D. R., Zidovetzki, R., & Hofman, F. M. (1998). Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest, 78(2), 165-174.
37. Wang, H. M., Zheng, N. G., Wu, J. L., Gong, C. C., & Wang, Y. L. (2005). Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol, 11(41), 6538-6542.
38. Warren, L., Manos, P. D., Ahfeldt, T., et al. (2010). Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modifed mRNA. Cell Stem Cell. [Epub ahead of print].
39. Desbordes, S. C., Placantonakis, D. G., Ciro, A., et al. (2008). High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2(6), 602-612.
40. Becker, K. A., Ghule, P. N., Lian, J. B., Stein, J. L., van Wijnen, A. J., & Stein, G. S. (2010). Cyclin D2 and the CDK substrate p220 (NPAT) are required for self-renewal of human embryonic stem cells. J Cell Physiol, 222(2), 456-464.