1,2,3-Triazole-heme interactions in cytochrome P450: Functionally competent triazole-water-heme complexes

Biochemistry

Volumn 51, Issue 32, 2012, Pages 6441-6457

  Conner, Kip P ^a   Vennam, Preethi ^b   Woods, Caleb M ^a   Krzyaniak, Matthew D ^b   Bowman, Michael K ^b   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,2 ,4-TRIAZOLE; AXIAL LIGAND; BINDING MODELS; CLICK CHEMISTRY; COMPLEX STRUCTURE; COMPUTATIONAL STUDIES; CONTINUOUS WAVES; CYTOCHROME P450; EPR SPECTROSCOPY; ETHYNYLESTRADIOL; HEME COMPLEXES; HEME IRON; HIGH-SPIN COMPLEXES; HYSCORE; ISOSTERIC; OPTICAL SPECTRA; TYPE II; WATER LIGANDS;

COMPLEXATION; DENSITY FUNCTIONAL THEORY; HYDROGEN BONDS; LIGANDS; NITROGEN COMPOUNDS; PARAMAGNETIC RESONANCE; PARAMAGNETISM;

PORPHYRINS;

1,2,3 TRIAZOLE DERIVATIVE; 1,2,4 TRIAZOLE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; ETHINYLESTRADIOL; HEME; IMIDAZOLE; WATER;

ARTICLE; CLICK CHEMISTRY; DENSITY FUNCTIONAL THEORY; ELECTRON SPIN RESONANCE; ENTHALPY; ENTROPY; HYDROGEN BOND; PRIORITY JOURNAL; THERMODYNAMICS;

CLICK CHEMISTRY; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ETHINYL ESTRADIOL; HEME; IMIDAZOLES; ISOMERISM; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; QUANTUM THEORY; THERMODYNAMICS; TRIAZOLES; WATER;

EID: 84865130391     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300744z     Document Type: Article

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