메뉴 건너뛰기




Volumn 1, Issue 2, 1997, Pages 176-182

The search for new triazole antifungal agents

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 1 [3 [2 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL]VINYL] 1,2,4 TRIAZOL 1 YL] 3 (1,2,4 TRIAZOL 1 YL) 2 PROPANOL; ANTIFUNGAL AGENT; NEW DRUG; POSACONAZOLE; PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE; VORICONAZOLE;

EID: 0031197111     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(97)80007-5     Document Type: Article
Times cited : (114)

References (52)
  • 1
    • 0001902681 scopus 로고
    • Antimicrobial agents: Antifungal agents
    • edn 9. Edited by Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG. New York: McGraw-Hill Inc
    • Bennett JE: Antimicrobial agents: antifungal agents. In Goodman and Gilman's, The Pharmacological Basis of Therapeutics, edn 9. Edited by Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG. New York: McGraw-Hill Inc; 1995:1175-1190.
    • (1995) Goodman and Gilman's, the Pharmacological Basis of Therapeutics , pp. 1175-1190
    • Bennett, J.E.1
  • 2
    • 17144466471 scopus 로고
    • National nosocomial infections surveillance: Secular trends in nosocomial primary blood stream infections in the United States, 1980-1989
    • Banerjee SN, Emori G, Culver DH, Gaynes RP, Jarvis WR, Horan T, Edwards JR, Tolson J, Henderson T, Martone WJ and The National Nosocomial Infections Surveillance System: National nosocomial infections surveillance: secular trends in nosocomial primary blood stream infections in the United States, 1980-1989. Am J Med 1991, 91(suppl 36):86-89.
    • (1991) Am J Med , vol.91 , Issue.36 SUPPL. , pp. 86-89
    • Banerjee, S.N.1    Emori, G.2    Culver, D.H.3    Gaynes, R.P.4    Jarvis, W.R.5    Horan, T.6    Edwards, J.R.7    Tolson, J.8    Henderson, T.9    Martone, W.J.10
  • 3
    • 0026737730 scopus 로고
    • Candidemia in a tertiary care hospital: Epidemiology, risk factors and predictors of mortality
    • Fraser VJ, Jones M, Dunkel J, Storfer S, Medoff G, Dunagan WC: Candidemia in a tertiary care hospital: epidemiology, risk factors and predictors of mortality. Clin Infect Dis 1992, 14:414-421.
    • (1992) Clin Infect Dis , vol.14 , pp. 414-421
    • Fraser, V.J.1    Jones, M.2    Dunkel, J.3    Storfer, S.4    Medoff, G.5    Dunagan, W.C.6
  • 4
    • 0025241257 scopus 로고
    • Antifungal and surgical treatment of invasive aspergillosis: Review of 2,121 published cases
    • Denning DW, Stevens DA: Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev Infect Dis 1990, 12:1147-1201.
    • (1990) Rev Infect Dis , vol.12 , pp. 1147-1201
    • Denning, D.W.1    Stevens, D.A.2
  • 5
    • 0030016915 scopus 로고    scopus 로고
    • Lipid formulations of amphotericin B: Recent progress and future directions
    • Hiemenz JW, Walsh TJ: Lipid formulations of amphotericin B: recent progress and future directions. Clin Infect Dis 1996, 22(suppl 2):133-144. A useful vignette of current and emerging liposomal formulations of amphotericin B and the development issues that require to be addressed before they can replace raw amphotericin B as first line therapy.
    • (1996) Clin Infect Dis , vol.22 , Issue.2 SUPPL. , pp. 133-144
    • Hiemenz, J.W.1    Walsh, T.J.2
  • 6
    • 0030449320 scopus 로고    scopus 로고
    • Amphotericin B: New life for an old drug
    • Hartsel S, Bolard J: Amphotericin B: new life for an old drug. Trends Pharmacol Sci 1996, 17:445-449.
    • (1996) Trends Pharmacol Sci , vol.17 , pp. 445-449
    • Hartsel, S.1    Bolard, J.2
  • 7
    • 0029083034 scopus 로고    scopus 로고
    • Fluconazole: An update on its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocompromised patients
    • Goa KL, Barradell LB: Fluconazole: an update on its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocompromised patients. Drugs 1996, 50:658-690. A comprehensive and well written review of fluconazole's role in the management of invasive and superficial fungal infections.
    • (1996) Drugs , vol.50 , pp. 658-690
    • Goa, K.L.1    Barradell, L.B.2
  • 8
    • 0024517330 scopus 로고
    • Itraconazole: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses
    • Grant SM, Clissold SP: Itraconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses. Drugs 1989, 37:310-344.
    • (1989) Drugs , vol.37 , pp. 310-344
    • Grant, S.M.1    Clissold, S.P.2
  • 9
    • 0029932717 scopus 로고    scopus 로고
    • Itraconazole: A reappraisal of its pharmacological properties and therapeutic use in the management of superficial infections
    • Haria M, Bryson HM, Goa KL. Itraconazole: a reappraisal of its pharmacological properties and therapeutic use in the management of superficial infections. Drugs 1996, 51:585-620, A thorough review of itraconazole underlining its growing importance in the treatment of superficial, as opposed to invasive, fungal infections.
    • (1996) Drugs , vol.51 , pp. 585-620
    • Haria, M.1    Bryson, H.M.2    Goa, K.L.3
  • 13
    • 0031015794 scopus 로고    scopus 로고
    • Itraconazole cyclodextrin solution; the role in in vitro susceptibility testing in predicting successful treatment of HIV-related fluconazole-resistant and fluconazole-susceptible oral candidiasis
    • Cartledge JD, Midgley J, Gazzard BG: Itraconazole cyclodextrin solution; the role in in vitro susceptibility testing in predicting successful treatment of HIV-related fluconazole-resistant and fluconazole-susceptible oral candidiasis. AIDS 1997, 11:163-168.
    • (1997) AIDS , vol.11 , pp. 163-168
    • Cartledge, J.D.1    Midgley, J.2    Gazzard, B.G.3
  • 14
    • 0030033020 scopus 로고    scopus 로고
    • Antifungal agents: Chemotherapeutic targets and immunologic strategies
    • Georgopapadakou NH, Walsh TJ: Antifungal agents: chemotherapeutic targets and immunologic strategies. Antimicrob Agents Chemother 1996, 40:279-291. A useful summary of current and emerging antifungal targets and inhibitors and of immunological approaches to treating fungal infections.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 279-291
    • Georgopapadakou, N.H.1    Walsh, T.J.2
  • 16
    • 0031052377 scopus 로고    scopus 로고
    • Development of interpretative breakpoints for antifungal susceptibility testing: Conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole and Candida infections
    • Rex JH, Pfaller MA, Galgiani JN, Bartlett MS, Espinel-Ingroff A, Ghannoum MA, Lancaster M, Odds FC, Rinaldi MG, Walsh TJ, Barry AL for the Subcommittee on Antifungal Susceptibility Testing of the National Committee for Clinical Laboratory Standards: Development of interpretative breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole and Candida infections. Clin Infect Dis 1997, 24:235-247. An excellent analysis of the relationship between in vitro susceptibility testing and clinical outcome for fluconazole and itraconazole against C. albicans. It draws on data that have accrued during the past decade and represents the benchmark for further in vitro-in vivo correlation studies in the antifungal area.
    • (1997) Clin Infect Dis , vol.24 , pp. 235-247
    • Rex, J.H.1    Pfaller, M.A.2    Galgiani, J.N.3    Bartlett, M.S.4    Espinel-Ingroff, A.5    Ghannoum, M.A.6    Lancaster, M.7    Odds, F.C.8    Rinaldi, M.G.9    Walsh, T.J.10    Barry, A.L.11
  • 17
    • 0029999845 scopus 로고    scopus 로고
    • Azole antifungal agents
    • Takashima K, Oki T: Azole antifungal agents. Exp Opin Ther Patents 1996, 6:645-654. A useful, concise review of current and emerging triazole derivatives.
    • (1996) Exp Opin Ther Patents , vol.6 , pp. 645-654
    • Takashima, K.1    Oki, T.2
  • 18
    • 0030594967 scopus 로고    scopus 로고
    • Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus
    • Dickinson RP, Bell AS, Hitchcock CA, Narayanaswami S, Ray SJ, Richardson K, Troke PF: Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus. Bioorg Med Chem Lett 1996, 6:2031-2036. This paper describes the key structure-activity relationships of exploratory triazoles, leading to the discovery of voriconazole and its potent antifungal activity in vitro and in vivo.
    • (1996) Bioorg Med Chem Lett , vol.6 , pp. 2031-2036
    • Dickinson, R.P.1    Bell, A.S.2    Hitchcock, C.A.3    Narayanaswami, S.4    Ray, S.J.5    Richardson, K.6    Troke, P.F.7
  • 21
    • 0029799501 scopus 로고    scopus 로고
    • Vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species
    • Barry AL, Brown SD: In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species. Antimicrob Agents Chemother 1996, 40:1948-1949. This paper emphasises the potent activity of voriconazole relative to that of fluconazole against a wide range of Candida spp.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1948-1949
    • Barry, A.L.1    Brown, S.D.2
  • 22
    • 0031028655 scopus 로고    scopus 로고
    • Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive aspergillosis
    • Murphy M, Bernard EM, Ishimaru T, Armstrong D: Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive aspergillosis. Antimicrob Agents Chemother 1997, 41:696-698.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 696-698
    • Murphy, M.1    Bernard, E.M.2    Ishimaru, T.3    Armstrong, D.4
  • 23
    • 0031025865 scopus 로고    scopus 로고
    • Vitro activities of voriconazole (UK-109,496) against fluconazole-susceptible and -resistant Candida albicans isolates from oral cavities of patients with human immunodeficiency virus infection
    • Ruhnke M, Schmidt-Westhausen A, Trautmann M: In vitro activities of voriconazole (UK-109,496) against fluconazole-susceptible and -resistant Candida albicans isolates from oral cavities of patients with human immunodeficiency virus infection. Antimicrob Agents Chemother 1997, 41:575-577. This paper emphasises that the potency advantage of voriconazole over fluconazole against Candida in vitro, translates to a clinical response to voriconazole in HIV patients with OPC refractory to fluconazole.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 575-577
    • Ruhnke, M.1    Schmidt-Westhausen, A.2    Trautmann, M.3
  • 26
    • 0342377328 scopus 로고
    • Evaluation of the in vitro activity of the new triazole voriconazole against opportunistic filamentous fungi
    • Washington, DC: American Society for Microbiology
    • Espinel-Ingroff A: Evaluation of the in vitro activity of the new triazole voriconazole against opportunistic filamentous fungi [abstract F84]. In Proceedings and Abstracts of the 36th Intersciences Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology; 1994:114.
    • (1994) Proceedings and Abstracts of the 36th Intersciences Conference on Antimicrobial Agents and Chemotherapy , pp. 114
    • Espinel-Ingroff, A.1
  • 28
    • 0030985567 scopus 로고    scopus 로고
    • Vitro studies of activity of voriconazole (UK-109,496), a new triazole antifungal agent, against emerging and less common mould pathogens
    • Radford SA, Johnson EM, Warnock DW: In vitro studies of activity of voriconazole (UK-109,496), a new triazole antifungal agent, against emerging and less common mould pathogens. Antimicrob Agents Chemother 1997, 41:841-843. This paper further highlights the broad-spectrum antifungal potency of voriconazole.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 841-843
    • Radford, S.A.1    Johnson, E.M.2    Warnock, D.W.3
  • 31
    • 0031030033 scopus 로고    scopus 로고
    • Comparison of voriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in guinea pigs
    • Martin MV, Yates J, Hitchcock CA: Comparison of voriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in guinea pigs. Antimicrob Agents Chemother 1997, 41:13-16. This paper is a good illustration of how voriconazole's fungicidal mechanism of action against Aspergillus in vitro translates to cures in a guinea pig model of Aspergillus endocarditis.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 13-16
    • Martin, M.V.1    Yates, J.2    Hitchcock, C.A.3
  • 32
    • 0002039234 scopus 로고
    • UK-109,496, a novel, wide-spectrum triazole derivative for the treatment of fungal infections: Activity in systemic candidiasis models and early clinical efficacy in oropharyngeal candidiasis
    • Washington, DC: American Society for Microbiology
    • Troke PF, Brammer KW, Hitchcock CA, Yonren S, Sarantis N: UK-109,496, a novel, wide-spectrum triazole derivative for the treatment of fungal infections: activity in systemic candidiasis models and early clinical efficacy in oropharyngeal candidiasis [abstract F73]. In Proceedings and Abstracts of the 35th Intersciences Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology; 1995:125.
    • (1995) Proceedings and Abstracts of the 35th Intersciences Conference on Antimicrobial Agents and Chemotherapy , pp. 125
    • Troke, P.F.1    Brammer, K.W.2    Hitchcock, C.A.3    Yonren, S.4    Sarantis, N.5
  • 33
    • 0000395961 scopus 로고
    • UK-109,496, a novel, wide-spectrum triazole derivative for the treatment of fungal infections: Antifungal activity in experimental infections with Cryptococcus
    • Washington, DC: American Society for Microbiology
    • Hitchcock CA, Andrews RJ, Lewis BGH, Troke PF: UK-109,496, a novel, wide-spectrum triazole derivative for the treatment of fungal infections: antifungal activity in experimental infections with Cryptococcus [abstract F75]. In Proceedings and Abstracts of the 35th Intersciences Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology; 1995:126.
    • (1995) Proceedings and Abstracts of the 35th Intersciences Conference on Antimicrobial Agents and Chemotherapy , pp. 126
    • Hitchcock, C.A.1    Andrews, R.J.2    Lewis, B.G.H.3    Troke, P.F.4
  • 34
    • 0030071574 scopus 로고    scopus 로고
    • Efficacy of UK-109,496, a new azole antifungal agent, in an experimental model of invasive aspergillosis
    • George D, Miniter P, Andriole VT: Efficacy of UK-109,496, a new azole antifungal agent, in an experimental model of invasive aspergillosis. Antimicrob Agents Chemother 1996, 40:86-91. This paper shows that although voriconazole is effective against invasive aspergillosis in rabbits, it is not as active as would be predicted from its potency in vitro. This reflects the rapid metabolism of voriconazole in this species, in contrast to guinea pigs and man.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 86-91
    • George, D.1    Miniter, P.2    Andriole, V.T.3
  • 35
    • 0002039230 scopus 로고
    • UK-109,496, a novel, wide-spectrum triazole derivative for the treatment of fungal infections: Pharmacokinetics in man
    • Washington, DC: American Society for Microbiology
    • Patterson BE, Coates PE: UK-109,496, a novel, wide-spectrum triazole derivative for the treatment of fungal infections: pharmacokinetics in man [abstract F78]. In Proceedings and Abstracts of the 35th Intersciences Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology; 1995:126.
    • (1995) Proceedings and Abstracts of the 35th Intersciences Conference on Antimicrobial Agents and Chemotherapy , pp. 126
    • Patterson, B.E.1    Coates, P.E.2
  • 38
    • 0029917158 scopus 로고    scopus 로고
    • SCH-56592
    • Fromtling RA, Castaner J: SCH-56592. Drugs Future 1996, 21:160-166. A useful review of the pre-clinical profile of SCH 56592, drawing on data that have been published in abstracts or full papers during the past two years.
    • (1996) Drugs Future , vol.21 , pp. 160-166
    • Fromtling, R.A.1    Castaner, J.2
  • 42
    • 0029817614 scopus 로고    scopus 로고
    • In vitro and in vivo efficacies of the azole SCH-56592 against Cryptococcus neoformans
    • Perfect JR, Cox GM, Dodge RK, Schell WA: In vitro and in vivo efficacies of the azole SCH-56592 against Cryptococcus neoformans. Antimicrob Agents Chemother 1996, 40:1910-1913. This paper shows that the potent activity of SCH-56592 against Cryptococcus in vitro translates to good efficacy in a rabbit model of cryptococcal meningitis.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1910-1913
    • Perfect, J.R.1    Cox, G.M.2    Dodge, R.K.3    Schell, W.A.4
  • 43
    • 0031027261 scopus 로고    scopus 로고
    • In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts
    • Galgiani JN, Lewis ML: In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts. Antimicrob Agents Chemother 1997, 41:180-183. This paper shows that SCH-56592 has potent, itraconazole-like activity against a wide range of yeasts. It also highlights that the results of susceptibility tests in standard media may be influenced by the method used to solubilise SCH-56592 and itraconazole.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 180-183
    • Galgiani, J.N.1    Lewis, M.L.2
  • 44
    • 0031054149 scopus 로고    scopus 로고
    • Activity of a new triazole, Sch 56592, compared with those of four other antifungal agents tested against clinical isolates of Candida spp. and Saccharomyces cerevisiae
    • Pfaller MA, Messer S, Jones RN: Activity of a new triazole, Sch 56592, compared with those of four other antifungal agents tested against clinical isolates of Candida spp. and Saccharomyces cerevisiae. Antimicrob Agents Chemother 1997, 41:233-235. This paper demonstrates that SCH-56592 is at least equivalent to itraconazole and significantly more potent than fluconazole against a wide range of clinically important yeasts.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 233-235
    • Pfaller, M.A.1    Messer, S.2    Jones, R.N.3
  • 45
    • 0001823084 scopus 로고    scopus 로고
    • An in vitro head-to-head comparison of Schering 56592, amphotericin B, fluconazole and itraconazole against a spectrum of filamentous fungi
    • Washington, DC: American Society for Microbiology
    • Fothergill AW, Sutton DA, Rinaldi MG: An in vitro head-to-head comparison of Schering 56592, amphotericin B, fluconazole and itraconazole against a spectrum of filamentous fungi [abstract F89]. In Proceedings and Abstracts of the 36th Intersciences Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology; 1996:115.
    • (1996) Proceedings and Abstracts of the 36th Intersciences Conference on Antimicrobial Agents and Chemotherapy , pp. 115
    • Fothergill, A.W.1    Sutton, D.A.2    Rinaldi, M.G.3
  • 52
    • 0030895761 scopus 로고    scopus 로고
    • A dose-comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis
    • De Wit S, Dupont B, Cartledge JD, Hawkins DA, Gazzard BG, Clumeck N, Denning DW: A dose-comparison study of a new triazole antifungal (D0870) in HIV-positive patients with oral candidiasis. AIDS 1997, 11:759-763.
    • (1997) AIDS , vol.11 , pp. 759-763
    • De Wit, S.1    Dupont, B.2    Cartledge, J.D.3    Hawkins, D.A.4    Gazzard, B.G.5    Clumeck, N.6    Denning, D.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.