NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation

Biochemistry

Volumn 50, Issue 12, 2011, Pages 2123-2134

  Roberts, Arthur G ^a   Sjögren, Sara E A ^b   Fomina, Nadezda ^a   Vu, Kathy T ^c   Almutairi, Adah ^a   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMIDE FUNCTIONAL GROUP; BINDING MODES; BOUND STRUCTURE; CYTOCHROME P450; DEMETHYLATION; HYDROPHOBIC POCKETS; LOCAL ANESTHETICS; MOLECULAR BASIS; N-DEALKYLATION; N-LINKED; NON-CATALYTIC; NUCLEAR MAGNETIC RESONANCE TECHNIQUES; RELAXATION RATES; SATURATION-TRANSFER DIFFERENCES; SEQUENTIAL OXIDATION; STRUCTURAL MECHANISMS; STRUCTURAL MODELS; X RAY CRYSTAL STRUCTURES;

AMIDES; ANESTHETICS; BINDING ENERGY; BIOMOLECULES; CRYSTAL ORIENTATION; ENZYMES; FUNCTIONAL GROUPS; METABOLISM; METABOLITES; MODEL STRUCTURES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PORPHYRINS; RESONANCE; SIMULATED ANNEALING;

NUCLEAR MAGNETIC RESONANCE;

AMINOPHENAZONE; CYTOCHROME P450 2B; CYTOCHROME P450 2B4; DESMETHYLAMIDOPYRINE; METHYL GROUP; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEALKYLATION; DEMETHYLATION; DRUG BINDING; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVE SITE; HYDROPHOBICITY; METABOLITE; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RABBIT; SATURATION TRANSFER DIFFERENCE SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ALKYLATION; AMINOPYRINE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOCATALYSIS; CATALYTIC DOMAIN; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; RABBITS; SPECTROPHOTOMETRY, ULTRAVIOLET;

ORYCTOLAGUS CUNICULUS;

EID: 79952931175     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101797v     Document Type: Article

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