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Volumn 10, Issue , 2012, Pages

Functions of the Lyn tyrosine kinase in health and disease

Author keywords

Cancer; Immune dysfunction; Leukaemia; Lyn tyrosine kinase; Oncoprotein signaling; Src family kinases

Indexed keywords

BAFETINIB; BCR ABL PROTEIN; CD135 ANTIGEN; DASATINIB; IMATINIB; LAPATINIB; MOLECULAR MARKER; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PROTEIN KINASE LYN; RETINOIC ACID; STAT5 PROTEIN; SUNITINIB; TRANSCRIPTION FACTOR ETV6; TUMOR MARKER;

EID: 84865098491     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-10-21     Document Type: Review
Times cited : (134)

References (112)
  • 1
    • 0037032835 scopus 로고    scopus 로고
    • The protein kinase complement of the human genome
    • 10.1126/science.1075762 12471243
    • The protein kinase complement of the human genome. Manning G, Whyte D, Martinez R, Hunter T, Sudarsanam S, Science 2002 298 1912 1934 10.1126/science.1075762 12471243
    • (2002) Science , vol.298 , pp. 1912-1934
    • Manning, G.1    Whyte, D.2    Martinez, R.3    Hunter, T.4    Sudarsanam, S.5
  • 3
    • 7944236785 scopus 로고    scopus 로고
    • Src family kinases, key regulators of signal transduction
    • 10.1038/sj.onc.1208160 15489908
    • Src family kinases, key regulators of signal transduction. Parsons SJ, Parsons JT, Oncogene 2004 23 7906 7909 10.1038/sj.onc.1208160 15489908
    • (2004) Oncogene , vol.23 , pp. 7906-7909
    • Parsons, S.J.1    Parsons, J.T.2
  • 4
    • 0032875098 scopus 로고    scopus 로고
    • Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins
    • 10.1016/S0167-4889(99)00075-0 10446384
    • Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Resh MD, Biochim Biophys Acta 1999 1451 1 16 10.1016/S0167-4889(99)00075-0 10446384
    • (1999) Biochim Biophys Acta , vol.1451 , pp. 1-16
    • Resh, M.D.1
  • 5
    • 7944223078 scopus 로고    scopus 로고
    • Structure and regulation of Src family kinases
    • 10.1038/sj.onc.1208081 15489910
    • Structure and regulation of Src family kinases. Boggon TJ, Eck MJ, Oncogene 2004 23 7918 7927 10.1038/sj.onc.1208081 15489910
    • (2004) Oncogene , vol.23 , pp. 7918-7927
    • Boggon, T.J.1    Eck, M.J.2
  • 6
    • 0028910092 scopus 로고
    • Identification of a duplication of the mouse Lyn gene
    • 10.1016/0378-1119(95)00022-X 7758954
    • Identification of a duplication of the mouse Lyn gene. Hibbs ML, Stanley E, Maglitto R, Dunn A, Gene 1995 156 175 181 10.1016/0378-1119(95)00022-X 7758954
    • (1995) Gene , vol.156 , pp. 175-181
    • Hibbs, M.L.1    Stanley, E.2    Maglitto, R.3    Dunn, A.4
  • 7
    • 0026350671 scopus 로고
    • Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus
    • 2017160
    • Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Yi T, Bolen JB, Ihle JN, Mol Cell Biol 1991 11 2391 2398 2017160
    • (1991) Mol Cell Biol , vol.11 , pp. 2391-2398
    • Yi, T.1    Bolen, J.B.2    Ihle, J.N.3
  • 8
    • 0025765803 scopus 로고
    • SH2 and SH3 domains: Elements that control interactions of cytoplasmic signalling proteins
    • 10.1126/science.1708916 1708916
    • SH2 and SH3 domains: elements that control interactions of cytoplasmic signalling proteins. Koch C, Anderson D, Moran M, Ellis C, Pawson T, Science 1991 252 668 674 10.1126/science.1708916 1708916
    • (1991) Science , vol.252 , pp. 668-674
    • Koch, C.1    Anderson, D.2    Moran, M.3    Ellis, C.4    Pawson, T.5
  • 9
    • 0037174989 scopus 로고    scopus 로고
    • Substrate conformational restriction and CD45-catalysed dephosphorylation of tail tyrosine-phosphorylated Src protein
    • 10.1074/jbc.M206467200 12181320
    • Substrate conformational restriction and CD45-catalysed dephosphorylation of tail tyrosine-phosphorylated Src protein. Wang D, Esselman WJ, Cole PA, J Biol Chem 2002 277 40428 40433 10.1074/jbc.M206467200 12181320
    • (2002) J Biol Chem , vol.277 , pp. 40428-40433
    • Wang, D.1    Esselman, W.J.2    Cole, P.A.3
  • 10
    • 79960999868 scopus 로고    scopus 로고
    • G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase
    • DOI:10.1182/blood-2009-1112-261636
    • G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ, Blood 2011 DOI:10.1182/blood-2009-1112-261636
    • (2011) Blood
    • Futami, M.1    Zhu, Q.S.2    Whichard, Z.L.3    Xia, L.4    Ke, Y.5    Neel, B.G.6    Feng, G.S.7    Corey, S.J.8
  • 11
    • 0033001789 scopus 로고    scopus 로고
    • Crystal structures of c-Src reveal features of its autoinhibitory mechanism
    • 10.1016/S1097-2765(00)80356-1 10360179
    • Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Xu W, Doshi A, Lei M, Eck MJ, Harrison SC, Mol Cell 1999 3 629 638 10.1016/S1097-2765(00)80356-1 10360179
    • (1999) Mol Cell , vol.3 , pp. 629-638
    • Xu, W.1    Doshi, A.2    Lei, M.3    Eck, M.J.4    Harrison, S.C.5
  • 12
    • 58649122152 scopus 로고    scopus 로고
    • Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state
    • 18984583
    • Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state. Williams NK, Lucet IS, Klinken SP, Ingley E, Rossjohn J, J Biol Chem 2009 284 284 291 18984583
    • (2009) J Biol Chem , vol.284 , pp. 284-291
    • Williams, N.K.1    Lucet, I.S.2    Klinken, S.P.3    Ingley, E.4    Rossjohn, J.5
  • 13
    • 0032563970 scopus 로고    scopus 로고
    • Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation
    • 10.1038/sj.onc.1202076 9794236
    • Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. Sun G, Sharma AK, Budde RJ, Oncogene 1998 17 1587 1595 10.1038/sj.onc.1202076 9794236
    • (1998) Oncogene , vol.17 , pp. 1587-1595
    • Sun, G.1    Sharma, A.K.2    Budde, R.J.3
  • 14
    • 0036330594 scopus 로고    scopus 로고
    • Effect of autophosphorylation on the catalytic and regulatory properties of protein tyrosine kinase Src
    • 10.1006/abbi.2001.2627 11747305
    • Effect of autophosphorylation on the catalytic and regulatory properties of protein tyrosine kinase Src. Sun G, Ramdas L, Wang W, Vinci J, McMurray J, Budde RJ, Arch Biochem Biophys 2002 397 11 17 10.1006/abbi.2001.2627 11747305
    • (2002) Arch Biochem Biophys , vol.397 , pp. 11-17
    • Sun, G.1    Ramdas, L.2    Wang, W.3    Vinci, J.4    McMurray, J.5    Budde, R.J.6
  • 15
    • 33846015045 scopus 로고    scopus 로고
    • Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells
    • 10.1074/jbc.M602637200 16920712
    • Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells. Ingley E, Schneider JR, Payne CJ, McCarthy DJ, Harder KW, Hibbs ML, Klinken SP, J Biol Chem 2006 281 31920 31929 10.1074/jbc.M602637200 16920712
    • (2006) J Biol Chem , vol.281 , pp. 31920-31929
    • Ingley, E.1    Schneider, J.R.2    Payne, C.J.3    McCarthy, D.J.4    Harder, K.W.5    Hibbs, M.L.6    Klinken, S.P.7
  • 16
    • 60649085974 scopus 로고    scopus 로고
    • Csk-binding protein can regulate Lyn signals controlling cell morphology
    • 10.1016/j.biocel.2008.12.001 19124084
    • Csk-binding protein can regulate Lyn signals controlling cell morphology. Ingley E, Int J Biochem Cell Biol 2009 41 1332 1343 10.1016/j.biocel.2008.12. 001 19124084
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1332-1343
    • Ingley, E.1
  • 17
    • 0034720166 scopus 로고    scopus 로고
    • Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
    • 10.1038/35010121 10801129
    • Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M, Nature 2000 404 999 1003 10.1038/35010121 10801129
    • (2000) Nature , vol.404 , pp. 999-1003
    • Kawabuchi, M.1    Satomi, Y.2    Takao, T.3    Shimonishi, Y.4    Nada, S.5    Nagai, K.6    Tarakhovsky, A.7    Okada, M.8
  • 18
    • 0342313755 scopus 로고    scopus 로고
    • Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation
    • 10.1084/jem.191.9.1591 10790433
    • Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, et al. J Exp Med 2000 191 1591 1604 10.1084/jem.191.9.1591 10790433
    • (2000) J Exp Med , vol.191 , pp. 1591-1604
    • Brdicka, T.1    Pavlistova, D.2    Leo, A.3    Bruyns, E.4    Korinek, V.5    Angelisova, P.6    Scherer, J.7    Shevchenko, A.8    Hilgert, I.9    Cerny, J.10
  • 19
    • 0035910564 scopus 로고    scopus 로고
    • The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells
    • 11042209
    • The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells. Somani AK, Yuen K, Xu F, Zhang J, Branch DR, Siminovitch KA, J Biol Chem 2001 276 1938 1944 11042209
    • (2001) J Biol Chem , vol.276 , pp. 1938-1944
    • Somani, A.K.1    Yuen, K.2    Xu, F.3    Zhang, J.4    Branch, D.R.5    Siminovitch, K.A.6
  • 20
    • 0028784215 scopus 로고
    • Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease
    • 10.1016/0092-8674(95)90171-X 7585947
    • Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease. Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR, Cell 1995 83 301 311 10.1016/0092-8674(95) 90171-X 7585947
    • (1995) Cell , vol.83 , pp. 301-311
    • Hibbs, M.L.1    Tarlinton, D.M.2    Armes, J.3    Grail, D.4    Hodgson, G.5    Maglitto, R.6    Stacker, S.A.7    Dunn, A.R.8
  • 22
    • 61849152775 scopus 로고    scopus 로고
    • Multiple roles of Lyn kinase in myeloid cell signaling and function
    • 10.1111/j.1600-065X.2008.00758.x 19290919
    • Multiple roles of Lyn kinase in myeloid cell signaling and function. Scapini P, Pereira S, Zhang H, Lowell CA, Immunol Rev 2009 228 23 40 10.1111/j.1600-065X.2008.00758.x 19290919
    • (2009) Immunol Rev , vol.228 , pp. 23-40
    • Scapini, P.1    Pereira, S.2    Zhang, H.3    Lowell, C.A.4
  • 23
    • 61849130484 scopus 로고    scopus 로고
    • The tyrosine kinase network regulating mast cell activation
    • 10.1111/j.1600-065X.2008.00742.x 19290926
    • The tyrosine kinase network regulating mast cell activation. Gilfillan AM, Rivera J, Immunol Rev 2009 228 149 169 10.1111/j.1600-065X.2008.00742.x 19290926
    • (2009) Immunol Rev , vol.228 , pp. 149-169
    • Gilfillan, A.M.1    Rivera, J.2
  • 24
    • 0030901234 scopus 로고    scopus 로고
    • Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells
    • 10.1093/emboj/16.7.1610 9130706
    • Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. Tilbrook PA, Ingley E, Williams JH, Hibbs ML, Klinken SP, EMBO J 1997 16 1610 1619 10.1093/emboj/16.7.1610 9130706
    • (1997) EMBO J , vol.16 , pp. 1610-1619
    • Tilbrook, P.A.1    Ingley, E.2    Williams, J.H.3    Hibbs, M.L.4    Klinken, S.P.5
  • 27
    • 0030833445 scopus 로고    scopus 로고
    • Lyn associates with the juxtamembrane region of c-kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells
    • 10.1074/jbc.272.43.27450 9341198
    • Lyn associates with the juxtamembrane region of c-kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells. Linnekin D, DeBerry CS, Mou S, J Biol Chem 1997 272 27450 27455 10.1074/jbc.272.43.27450 9341198
    • (1997) J Biol Chem , vol.272 , pp. 27450-27455
    • Linnekin, D.1    Deberry, C.S.2    Mou, S.3
  • 28
    • 0032931978 scopus 로고    scopus 로고
    • Src-related protein tyrosine kinases in hematopoiesis
    • 9864140
    • Src-related protein tyrosine kinases in hematopoiesis. Corey SJ, Anderson SM, Blood 1999 93 1 14 9864140
    • (1999) Blood , vol.93 , pp. 1-14
    • Corey, S.J.1    Anderson, S.M.2
  • 29
    • 33750606752 scopus 로고    scopus 로고
    • The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling
    • 10.1080/08977190600581327 16801133
    • The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling. Hibbs ML, Harder KW, Growth Factors 2006 24 137 149 10.1080/08977190600581327 16801133
    • (2006) Growth Factors , vol.24 , pp. 137-149
    • Hibbs, M.L.1    Harder, K.W.2
  • 30
    • 65449155551 scopus 로고    scopus 로고
    • The novel role for lyn in integrin signaling in human disease
    • 10.2174/157436209787048685
    • The novel role for lyn in integrin signaling in human disease. Tomkowicz B, Ptasznik A, Curr Signal Transduct Ther 2009 4 59 65 10.2174/ 157436209787048685
    • (2009) Curr Signal Transduct Ther , vol.4 , pp. 59-65
    • Tomkowicz, B.1    Ptasznik, A.2
  • 32
    • 0034678125 scopus 로고    scopus 로고
    • HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells
    • 10.1074/jbc.275.11.7887 10713104
    • HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. Ingley E, Sarna MK, Beaumont JG, Tilbrook PA, Tsai S, Takemoto Y, Williams JH, Klinken SP, J Biol Chem 2000 275 7887 7893 10.1074/jbc.275.11.7887 10713104
    • (2000) J Biol Chem , vol.275 , pp. 7887-7893
    • Ingley, E.1    Sarna, M.K.2    Beaumont, J.G.3    Tilbrook, P.A.4    Tsai, S.5    Takemoto, Y.6    Williams, J.H.7    Klinken, S.P.8
  • 33
    • 0032525115 scopus 로고    scopus 로고
    • Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway
    • 9573010
    • Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Chin H, Arai A, Wakao H, Kamiyama R, Miyasaka N, Miura O, Blood 1998 91 3734 3745 9573010
    • (1998) Blood , vol.91 , pp. 3734-3745
    • Chin, H.1    Arai, A.2    Wakao, H.3    Kamiyama, R.4    Miyasaka, N.5    Miura, O.6
  • 35
    • 10244225231 scopus 로고    scopus 로고
    • Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
    • 10.1182/blood-2003-12-4396 15339845
    • Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Harder KW, Quilici C, Naik E, Inglese M, Kountouri N, Turner A, Zlatic K, Tarlinton DM, Hibbs ML, Blood 2004 104 3901 3910 10.1182/blood-2003-12-4396 15339845
    • (2004) Blood , vol.104 , pp. 3901-3910
    • Harder, K.W.1    Quilici, C.2    Naik, E.3    Inglese, M.4    Kountouri, N.5    Turner, A.6    Zlatic, K.7    Tarlinton, D.M.8    Hibbs, M.L.9
  • 36
    • 0242586087 scopus 로고    scopus 로고
    • Impairment of N-methyl-D-aspartate receptor-controlled motor activity in LYN-deficient mice
    • 10.1016/S0306-4522(03)00025-3 12710978
    • Impairment of N-methyl-D-aspartate receptor-controlled motor activity in LYN-deficient mice. Umemori H, Ogura H, Tozawa N, Mikoshiba K, Nishizumi H, Yamamoto T, Neuroscience 2003 118 709 713 10.1016/S0306-4522(03)00025-3 12710978
    • (2003) Neuroscience , vol.118 , pp. 709-713
    • Umemori, H.1    Ogura, H.2    Tozawa, N.3    Mikoshiba, K.4    Nishizumi, H.5    Yamamoto, T.6
  • 37
    • 0842347483 scopus 로고    scopus 로고
    • Lyn is a target gene for prostate cancer: Sequence-based inhibition induces regression of human tumor xenografts
    • 10.1158/0008-5472.CAN-03-2420 14871838
    • Lyn is a target gene for prostate cancer: Sequence-based inhibition induces regression of human tumor xenografts. Goldenberg-Furmanov M, Stein I, Pikarsky E, Rubin H, Kasem S, Wygoda M, Weinstein I, Reuveni H, Ben-Sasson SA, Cancer Res 2004 64 1058 1066 10.1158/0008-5472.CAN-03-2420 14871838
    • (2004) Cancer Res , vol.64 , pp. 1058-1066
    • Goldenberg-Furmanov, M.1    Stein, I.2    Pikarsky, E.3    Rubin, H.4    Kasem, S.5    Wygoda, M.6    Weinstein, I.7    Reuveni, H.8    Ben-Sasson, S.A.9
  • 39
    • 58149287842 scopus 로고    scopus 로고
    • A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function
    • 10.1016/j.molcel.2008.12.024 19150426
    • A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function. Barouch-Bentov R, Che J, Lee CC, Yang Y, Herman A, Jia Y, Velentza A, Watson J, Sternberg L, Kim S, et al. Mol Cell 2009 33 43 52 10.1016/j.molcel.2008.12.024 19150426
    • (2009) Mol Cell , vol.33 , pp. 43-52
    • Barouch-Bentov, R.1    Che, J.2    Lee, C.C.3    Yang, Y.4    Herman, A.5    Jia, Y.6    Velentza, A.7    Watson, J.8    Sternberg, L.9    Kim, S.10
  • 40
    • 33748201123 scopus 로고    scopus 로고
    • Lyn kinase promotes erythroblast expansion and late-stage development
    • 10.1182/blood-2005-09-008243 16705093
    • Lyn kinase promotes erythroblast expansion and late-stage development. Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM, Blood 2006 108 1524 1532 10.1182/blood-2005-09-008243 16705093
    • (2006) Blood , vol.108 , pp. 1524-1532
    • Karur, V.G.1    Lowell, C.A.2    Besmer, P.3    Agosti, V.4    Wojchowski, D.M.5
  • 41
    • 0031030067 scopus 로고    scopus 로고
    • Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport
    • 10.1172/JCI119150 9005990
    • Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G, J Clin Invest 1997 99 220 227 10.1172/JCI119150 9005990
    • (1997) J Clin Invest , vol.99 , pp. 220-227
    • De Franceschi, L.1    Fumagalli, L.2    Olivieri, O.3    Corrocher, R.4    Lowell, C.A.5    Berton, G.6
  • 42
    • 0034663190 scopus 로고    scopus 로고
    • Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: Identification of primary and secondary phosphorylation sites
    • 10942405
    • Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites. Brunati AM, Bordin L, Clari G, James P, Quadroni M, Baritono E, Pinna LA, Donella-Deana A, Blood 2000 96 1550 1557 10942405
    • (2000) Blood , vol.96 , pp. 1550-1557
    • Brunati, A.M.1    Bordin, L.2    Clari, G.3    James, P.4    Quadroni, M.5    Baritono, E.6    Pinna, L.A.7    Donella-Deana, A.8
  • 43
    • 0037564432 scopus 로고    scopus 로고
    • Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells
    • 10.1016/S0006-291X(03)00762-9 12763027
    • Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells. Maccaglia A, Mallozzi C, Minetti M, Biochem Biophys Res Comm 2003 305 541 547 10.1016/S0006-291X(03)00762-9 12763027
    • (2003) Biochem Biophys Res Comm , vol.305 , pp. 541-547
    • MacCaglia, A.1    Mallozzi, C.2    Minetti, M.3
  • 45
    • 20444375078 scopus 로고    scopus 로고
    • Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein
    • 10.1074/jbc.M412634200 15795233
    • Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein. Brunati AM, Deana R, Folda A, Massimino ML, Marin O, Ledro S, Pinna LA, Donella-Deana A, J Biol Chem 2005 280 21029 21035 10.1074/jbc.M412634200 15795233
    • (2005) J Biol Chem , vol.280 , pp. 21029-21035
    • Brunati, A.M.1    Deana, R.2    Folda, A.3    Massimino, M.L.4    Marin, O.5    Ledro, S.6    Pinna, L.A.7    Donella-Deana, A.8
  • 46
    • 0030997718 scopus 로고    scopus 로고
    • Translocation of the csk homologous kinase (chk/hyl) controls activity of cd36-anchored lyn tyrosine kinase in thrombin-stimulated platelets
    • 10.1093/emboj/16.9.2342 9171348
    • Translocation of the csk homologous kinase (chk/hyl) controls activity of cd36-anchored lyn tyrosine kinase in thrombin-stimulated platelets. Hirao A, Hamaguchi I, Suda T, Yamaguchi N, EMBO J 1997 16 2342 2351 10.1093/emboj/16.9. 2342 9171348
    • (1997) EMBO J , vol.16 , pp. 2342-2351
    • Hirao, A.1    Hamaguchi, I.2    Suda, T.3    Yamaguchi, N.4
  • 47
    • 3543010757 scopus 로고    scopus 로고
    • SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets
    • 10.1074/jbc.M400746200 15166241
    • SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. Maxwell MJ, Yuan Y, Anderson KE, Hibbs ML, Salem HH, Jackson SP, J Biol Chem 2004 279 32196 32204 10.1074/jbc.M400746200 15166241
    • (2004) J Biol Chem , vol.279 , pp. 32196-32204
    • Maxwell, M.J.1    Yuan, Y.2    Anderson, K.E.3    Hibbs, M.L.4    Salem, H.H.5    Jackson, S.P.6
  • 48
    • 0034672357 scopus 로고    scopus 로고
    • Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway
    • 11110698
    • Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP, Blood 2000 96 4246 4253 11110698
    • (2000) Blood , vol.96 , pp. 4246-4253
    • Quek, L.S.1    Pasquet, J.M.2    Hers, I.3    Cornall, R.4    Knight, G.5    Barnes, M.6    Hibbs, M.L.7    Dunn, A.R.8    Lowell, C.A.9    Watson, S.P.10
  • 52
    • 77954470691 scopus 로고    scopus 로고
    • Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation
    • 10.4049/jimmunol.0904064 20308635
    • Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation. Alvarez-Errico D, Yamashita Y, Suzuki R, Odom S, Furumoto Y, Yamashita T, Rivera J, J Immunol 2010 184 5000 5008 10.4049/jimmunol.0904064 20308635
    • (2010) J Immunol , vol.184 , pp. 5000-5008
    • Alvarez-Errico, D.1    Yamashita, Y.2    Suzuki, R.3    Odom, S.4    Furumoto, Y.5    Yamashita, T.6    Rivera, J.7
  • 54
    • 0035393501 scopus 로고    scopus 로고
    • A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-Kinase/Akt in colon carcinoma cells
    • 11431370
    • A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-Kinase/Akt in colon carcinoma cells. Bates RC, Edwards NS, Burns GF, Fisher DE, Cancer Res 2001 61 5275 5283 11431370
    • (2001) Cancer Res , vol.61 , pp. 5275-5283
    • Bates, R.C.1    Edwards, N.S.2    Burns, G.F.3    Fisher, D.E.4
  • 56
    • 21344470873 scopus 로고    scopus 로고
    • Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells
    • 10.1158/0008-5472.CAN-04-3688 15994925
    • Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells. Stettner MR, Wang W, Nabors LB, Bharara S, Flynn DC, Grammer JR, Gillespie GY, Gladson CL, Cancer Res 2005 65 5535 5543 10.1158/0008-5472.CAN-04-3688 15994925
    • (2005) Cancer Res , vol.65 , pp. 5535-5543
    • Stettner, M.R.1    Wang, W.2    Nabors, L.B.3    Bharara, S.4    Flynn, D.C.5    Grammer, J.R.6    Gillespie, G.Y.7    Gladson, C.L.8
  • 58
    • 0034911522 scopus 로고    scopus 로고
    • Expression of B cell receptor-associated signaling molecules in human lupus
    • 10.3109/08916930109008048 11683380
    • Expression of B cell receptor-associated signaling molecules in human lupus. Huck S, Le Corre R, Youinou P, Zouali M, Autoimmunity 2001 33 213 224 10.3109/08916930109008048 11683380
    • (2001) Autoimmunity , vol.33 , pp. 213-224
    • Huck, S.1    Le Corre, R.2    Youinou, P.3    Zouali, M.4
  • 59
    • 0032479926 scopus 로고    scopus 로고
    • Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation
    • 10.1084/jem.188.3.421 9687520
    • Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation. Pazdrak K, Olszewska-Pazdrak B, Stafford S, Garofalo RP, Alam R, J Exp Med 1998 188 421 429 10.1084/jem.188.3.421 9687520
    • (1998) J Exp Med , vol.188 , pp. 421-429
    • Pazdrak, K.1    Olszewska-Pazdrak, B.2    Stafford, S.3    Garofalo, R.P.4    Alam, R.5
  • 60
    • 0033565287 scopus 로고    scopus 로고
    • A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation
    • 10395690
    • A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. Adachi T, Stafford S, Sur S, Alam R, J Immunol 1999 163 939 946 10395690
    • (1999) J Immunol , vol.163 , pp. 939-946
    • Adachi, T.1    Stafford, S.2    Sur, S.3    Alam, R.4
  • 61
    • 64049085018 scopus 로고    scopus 로고
    • Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    • 10.1016/j.immuni.2009.02.008 19362019
    • Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Charles N, Watford WT, Ramos HL, Hellman L, Oettgen HC, Gomez G, Ryan JJ, O'Shea JJ, Rivera J, Immunity 2009 30 533 543 10.1016/j.immuni.2009.02.008 19362019
    • (2009) Immunity , vol.30 , pp. 533-543
    • Charles, N.1    Watford, W.T.2    Ramos, H.L.3    Hellman, L.4    Oettgen, H.C.5    Gomez, G.6    Ryan, J.J.7    O'Shea, J.J.8    Rivera, J.9
  • 62
    • 77949322552 scopus 로고    scopus 로고
    • Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    • 10.4049/jimmunol.0901878 20042579
    • Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. Tsantikos E, Oracki SA, Quilici C, Anderson GP, Tarlinton DM, Hibbs ML, J Immunol 2010 184 1348 1360 10.4049/jimmunol.0901878 20042579
    • (2010) J Immunol , vol.184 , pp. 1348-1360
    • Tsantikos, E.1    Oracki, S.A.2    Quilici, C.3    Anderson, G.P.4    Tarlinton, D.M.5    Hibbs, M.L.6
  • 63
    • 77955343903 scopus 로고    scopus 로고
    • Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
    • 10.1084/jem.20100086 20624892
    • Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA, J Exp Med 2010 207 1757 1773 10.1084/jem.20100086 20624892
    • (2010) J Exp Med , vol.207 , pp. 1757-1773
    • Scapini, P.1    Hu, Y.2    Chu, C.L.3    Migone, T.S.4    Defranco, A.L.5    Cassatella, M.A.6    Lowell, C.A.7
  • 64
    • 0037389275 scopus 로고    scopus 로고
    • The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis
    • 12586738
    • The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis. Luciano F, Herrant M, Jacquel A, Ricci JE, Auberger P, FASEB J 2003 17 711 713 12586738
    • (2003) FASEB J , vol.17 , pp. 711-713
    • Luciano, F.1    Herrant, M.2    Jacquel, A.3    Ricci, J.E.4    Auberger, P.5
  • 66
    • 0035899499 scopus 로고    scopus 로고
    • Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: A new mechanism for Src kinase regulation
    • 10.1038/sj.onc.1204661 11526478
    • Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation. Luciano F, Ricci JE, Auberger P, Oncogene 2001 20 4935 4941 10.1038/sj.onc.1204661 11526478
    • (2001) Oncogene , vol.20 , pp. 4935-4941
    • Luciano, F.1    Ricci, J.E.2    Auberger, P.3
  • 67
    • 3142751485 scopus 로고    scopus 로고
    • SRC in human carcinogenesis
    • 10.2741/1138 12957809
    • SRC in human carcinogenesis. Russello SV, Shore SK, Front Biosci 2003 8 1068 S1073 10.2741/1138 12957809
    • (2003) Front Biosci , vol.8
    • Russello, S.V.1    Shore, S.K.2
  • 68
    • 0041513490 scopus 로고    scopus 로고
    • C-Src tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis
    • 12941830
    • C-Src tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis. Myoui A, Nishimura R, Williams PJ, Hiraga T, Tamura D, Michigami T, Mundy GR, Yoneda T, Cancer Res 2003 63 5028 5033 12941830
    • (2003) Cancer Res , vol.63 , pp. 5028-5033
    • Myoui, A.1    Nishimura, R.2    Williams, P.J.3    Hiraga, T.4    Tamura, D.5    Michigami, T.6    Mundy, G.R.7    Yoneda, T.8
  • 69
    • 33847306882 scopus 로고    scopus 로고
    • Nonreceptor tyrosine kinases in prostate cancer
    • 10.1593/neo.06694 17357254
    • Nonreceptor tyrosine kinases in prostate cancer. Chang YM, Kung HJ, Evans CP, Neoplasia 2007 9 90 100 10.1593/neo.06694 17357254
    • (2007) Neoplasia , vol.9 , pp. 90-100
    • Chang, Y.M.1    Kung, H.J.2    Evans, C.P.3
  • 73
    • 77950284093 scopus 로고    scopus 로고
    • LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer
    • 10.1158/0008-5472.CAN-09-3141 20215510
    • LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer. Choi YL, Bocanegra M, Kwon MJ, Shin YK, Nam SJ, Yang JH, Kao J, Godwin AK, Pollack JR, Cancer Res 2010 70 2296 2306 10.1158/0008-5472.CAN-09-3141 20215510
    • (2010) Cancer Res , vol.70 , pp. 2296-2306
    • Choi, Y.L.1    Bocanegra, M.2    Kwon, M.J.3    Shin, Y.K.4    Nam, S.J.5    Yang, J.H.6    Kao, J.7    Godwin, A.K.8    Pollack, J.R.9
  • 74
    • 2442465000 scopus 로고    scopus 로고
    • Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    • 10.1038/ng1343 15098032
    • Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Hu YG, Liu YH, Pelletier S, Buchdunger E, Warmuth M, Fabbro D, Hallek M, Van Etten RA, Li SG, Nat Genet 2004 36 453 461 10.1038/ng1343 15098032
    • (2004) Nat Genet , vol.36 , pp. 453-461
    • Hu, Y.G.1    Liu, Y.H.2    Pelletier, S.3    Buchdunger, E.4    Warmuth, M.5    Fabbro, D.6    Hallek, M.7    Van Etten, R.A.8    Li, S.G.9
  • 75
    • 0032969381 scopus 로고    scopus 로고
    • Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth
    • 10.1038/sj.leu.2401429
    • Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth. Roginskaya V, Zuo S, Caudell E, Nambudiri G, Kraker AJ, Corey SJ, Leukaemia 1999 13 855 861 10.1038/sj.leu.2401429
    • (1999) Leukaemia , vol.13 , pp. 855-861
    • Roginskaya, V.1    Zuo, S.2    Caudell, E.3    Nambudiri, G.4    Kraker, A.J.5    Corey, S.J.6
  • 76
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
    • 10.1182/blood.V101.2.690 12509383
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Donato NJ, Wu JY, Stapley J, Gallick G, Lin H, Arlinghaus R, Talpaz M, Blood 2003 101 690 698 10.1182/blood.V101.2.690 12509383
    • (2003) Blood , vol.101 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3    Gallick, G.4    Lin, H.5    Arlinghaus, R.6    Talpaz, M.7
  • 77
    • 78650662553 scopus 로고    scopus 로고
    • Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
    • 10.1182/blood-2010-05-283937 20858858
    • Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease. Xiao W, Ando T, Wang HY, Kawakami Y, Kawakami T, Blood 2010 116 6003 6013 10.1182/blood-2010-05- 283937 20858858
    • (2010) Blood , vol.116 , pp. 6003-6013
    • Xiao, W.1    Ando, T.2    Wang, H.Y.3    Kawakami, Y.4    Kawakami, T.5
  • 78
    • 41349089065 scopus 로고    scopus 로고
    • A critical role for Lyn in acute myeloid leukemia
    • 10.1182/blood-2007-04-082099 18056483
    • A critical role for Lyn in acute myeloid leukemia. Dos Santos C, Demur C, Bardet V, Prade-Houdellier N, Payrastre B, Recher C, Blood 2008 111 2269 2279 10.1182/blood-2007-04-082099 18056483
    • (2008) Blood , vol.111 , pp. 2269-2279
    • Dos Santos, C.1    Demur, C.2    Bardet, V.3    Prade-Houdellier, N.4    Payrastre, B.5    Recher, C.6
  • 81
    • 79955730965 scopus 로고    scopus 로고
    • Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis
    • 10.1111/j.1365-2141.2011.08663.x
    • Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis. Takeda Y, Nakaseko C, Tanaka H, Takeuchi M, Yui M, Saraya A, Miyagi S, Wang C, Tanaka S, Ohwada C, et al. Brit J Haematol 2011 153 589 598 10.1111/j.1365-2141.2011.08663.x
    • (2011) Brit J Haematol , vol.153 , pp. 589-598
    • Takeda, Y.1    Nakaseko, C.2    Tanaka, H.3    Takeuchi, M.4    Yui, M.5    Saraya, A.6    Miyagi, S.7    Wang, C.8    Tanaka, S.9    Ohwada, C.10
  • 82
    • 0037439689 scopus 로고    scopus 로고
    • SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
    • 12543790
    • SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Golas JM, Arndt K, Etienne C, Lucas J, Nardin D, Gibbons J, Frost P, Ye F, Boschelli DH, Boschelli F, Cancer Res 2003 63 375 381 12543790
    • (2003) Cancer Res , vol.63 , pp. 375-381
    • Golas, J.M.1    Arndt, K.2    Etienne, C.3    Lucas, J.4    Nardin, D.5    Gibbons, J.6    Frost, P.7    Ye, F.8    Boschelli, D.H.9    Boschelli, F.10
  • 83
    • 0037438513 scopus 로고    scopus 로고
    • Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases
    • 10.1182/blood-2002-01-0288 12393636
    • Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases. Warmuth M, Simon N, Mitina O, Mathes R, Fabbro D, Manley PW, Buchdunger E, Forster K, Moarefi I, Hallek M, Blood 2003 101 664 672 10.1182/blood-2002- 01-0288 12393636
    • (2003) Blood , vol.101 , pp. 664-672
    • Warmuth, M.1    Simon, N.2    Mitina, O.3    Mathes, R.4    Fabbro, D.5    Manley, P.W.6    Buchdunger, E.7    Forster, K.8    Moarefi, I.9    Hallek, M.10
  • 84
    • 0037153476 scopus 로고    scopus 로고
    • Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis
    • 10.1038/sj.onc.1206008 12444544
    • Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE, Oncogene 2002 21 8075 8088 10.1038/sj.onc.1206008 12444544
    • (2002) Oncogene , vol.21 , pp. 8075-8088
    • Wilson, M.B.1    Schreiner, S.J.2    Choi, H.J.3    Kamens, J.4    Smithgall, T.E.5
  • 85
    • 33847210356 scopus 로고    scopus 로고
    • Lyn is an important component of the signal transduction pathway specific to FLT3//ITD and can be a therapeutic target in the treatment of AML with FLT3//ITD
    • 10.1038/sj.leu.2404547 17230226
    • Lyn is an important component of the signal transduction pathway specific to FLT3//ITD and can be a therapeutic target in the treatment of AML with FLT3//ITD. Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T, Leukemia 2007 21 403 410 10.1038/sj.leu.2404547 17230226
    • (2007) Leukemia , vol.21 , pp. 403-410
    • Okamoto, M.1    Hayakawa, F.2    Miyata, Y.3    Watamoto, K.4    Emi, N.5    Abe, A.6    Kiyoi, H.7    Towatari, M.8    Naoe, T.9
  • 86
    • 84862000561 scopus 로고    scopus 로고
    • Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells
    • 10.1038/leu.2011.390
    • Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells. Congleton J, Macdonald R, Yen A, Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, UK 2012 26 1180 1188 10.1038/leu.2011.390
    • (2012) Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK , vol.26 , pp. 1180-1188
    • Congleton, J.1    MacDonald, R.2    Yen, A.3
  • 87
    • 33750083890 scopus 로고    scopus 로고
    • Src Family Kinases Phosphorylate the Bcr-Abl SH3-SH2 Region and Modulate Bcr-Abl Transforming Activity
    • 10.1074/jbc.M605902200 16912036
    • Src Family Kinases Phosphorylate the Bcr-Abl SH3-SH2 Region and Modulate Bcr-Abl Transforming Activity. Meyn MA, Wilson MB, Abdi FA, Fahey N, Schiavone AP, Wu J, Hochrein JM, Engen JR, Smithgall TE, J Biol Chem 2006 281 30907 30916 10.1074/jbc.M605902200 16912036
    • (2006) J Biol Chem , vol.281 , pp. 30907-30916
    • Meyn, M.A.1    Wilson, M.B.2    Abdi, F.A.3    Fahey, N.4    Schiavone, A.P.5    Wu, J.6    Hochrein, J.M.7    Engen, J.R.8    Smithgall, T.E.9
  • 88
    • 43549100498 scopus 로고    scopus 로고
    • Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib resistant chronis myelogenous leukemia cells
    • 10.1182/blood-2007-08-109330 18235045
    • Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib resistant chronis myelogenous leukemia cells. Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z, Talpaz M, Donato NJ, Blood 2008 111 3821 3829 10.1182/blood-2007-08-109330 18235045
    • (2008) Blood , vol.111 , pp. 3821-3829
    • Wu, J.1    Meng, F.2    Lu, H.3    Kong, L.4    Bornmann, W.5    Peng, Z.6    Talpaz, M.7    Donato, N.J.8
  • 90
    • 64949147229 scopus 로고    scopus 로고
    • Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients
    • 10.1038/onc.2009.7 19234487
    • Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Samanta AK, Chakraborty SN, Wang Y, Kantarjian H, Sun X, Hood J, Perrotti D, Arlinghaus RB, Oncogene 2009 28 1669 1681 10.1038/onc.2009.7 19234487
    • (2009) Oncogene , vol.28 , pp. 1669-1681
    • Samanta, A.K.1    Chakraborty, S.N.2    Wang, Y.3    Kantarjian, H.4    Sun, X.5    Hood, J.6    Perrotti, D.7    Arlinghaus, R.B.8
  • 91
    • 9144223047 scopus 로고    scopus 로고
    • Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
    • 10.1038/nm1127 15502840
    • Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells. Ptasznik A, Nakata Y, Kalota A, Emerson SG, Gewirtz AM, Nat Med 2004 10 1187 1189 10.1038/nm1127 15502840
    • (2004) Nat Med , vol.10 , pp. 1187-1189
    • Ptasznik, A.1    Nakata, Y.2    Kalota, A.3    Emerson, S.G.4    Gewirtz, A.M.5
  • 92
    • 79953250081 scopus 로고    scopus 로고
    • Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling
    • 10.1126/scisignal.2001314 21447799
    • Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling. Rubbi L, Titz B, Brown L, Galvan E, Komisopoulou E, Chen SS, Low T, Tahmasian M, Skaggs B, Muschen M, et al. Sci Signal 2011 4 a18 10.1126/scisignal.2001314 21447799
    • (2011) Sci Signal , vol.4
    • Rubbi, L.1    Titz, B.2    Brown, L.3    Galvan, E.4    Komisopoulou, E.5    Chen, S.S.6    Low, T.7    Tahmasian, M.8    Skaggs, B.9    Muschen, M.10
  • 93
    • 0035141252 scopus 로고    scopus 로고
    • SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF
    • 10.1128/MCB.21.4.1077-1088.2001 11158295
    • SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Wang B, Lemay S, Tsai S, Veillette A, Mol Cell Biol 2001 21 1077 1088 10.1128/MCB.21.4.1077-1088.2001 11158295
    • (2001) Mol Cell Biol , vol.21 , pp. 1077-1088
    • Wang, B.1    Lemay, S.2    Tsai, S.3    Veillette, A.4
  • 95
    • 79952743082 scopus 로고    scopus 로고
    • Bafetinib, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia
    • 21154127
    • Bafetinib, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia. Santos FP, Kantarjian H, Cortes J, Quintas-Cardama A, Curr Opin Investig Drugs 2010 11 1450 1465 21154127
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1450-1465
    • Santos, F.P.1    Kantarjian, H.2    Cortes, J.3    Quintas-Cardama, A.4
  • 96
    • 70350507997 scopus 로고    scopus 로고
    • AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
    • 10.1016/j.ccr.2009.09.028 19878872
    • AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, et al. Cancer Cell 2009 16 401 412 10.1016/j.ccr.2009.09.028 19878872
    • (2009) Cancer Cell , vol.16 , pp. 401-412
    • O'Hare, T.1    Shakespeare, W.C.2    Zhu, X.3    Eide, C.A.4    Rivera, V.M.5    Wang, F.6    Adrian, L.T.7    Zhou, T.8    Huang, W.S.9    Xu, Q.10
  • 97
    • 84863518421 scopus 로고    scopus 로고
    • Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT
    • 10.1182/blood-2012-01-403162 22569400
    • Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Negro R, Gobessi S, Longo PG, He Y, Zhang ZY, Laurenti L, Efremov DG, Blood 2012 119 6278 6287 10.1182/blood-2012-01-403162 22569400
    • (2012) Blood , vol.119 , pp. 6278-6287
    • Negro, R.1    Gobessi, S.2    Longo, P.G.3    He, Y.4    Zhang, Z.Y.5    Laurenti, L.6    Efremov, D.G.7
  • 98
    • 3042753412 scopus 로고    scopus 로고
    • Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector
    • 10.1016/j.bbrc.2004.06.040 15240136
    • Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector. Abe A, Emi N, Kanie T, Imagama S, Kuno Y, Takahashi M, Saito H, Naoe T, Biochem Biophys Res Comm 2004 320 920 926 10.1016/j.bbrc.2004.06.040 15240136
    • (2004) Biochem Biophys Res Comm , vol.320 , pp. 920-926
    • Abe, A.1    Emi, N.2    Kanie, T.3    Imagama, S.4    Kuno, Y.5    Takahashi, M.6    Saito, H.7    Naoe, T.8
  • 100
    • 0037150728 scopus 로고    scopus 로고
    • Src in cancer: Deregulation and consequences for cell behaviour
    • 12020799
    • Src in cancer: deregulation and consequences for cell behaviour. Frame MC, Biochim Biophys Acta 2002 1602 114 130 12020799
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 114-130
    • Frame, M.C.1
  • 101
    • 0017337982 scopus 로고
    • Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants
    • 10.1016/0042-6822(77)90305-1 189495
    • Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants. Deng CT, Stehelin D, Bishop JM, Varmus HE, Virology 1977 76 313 330 10.1016/0042-6822(77)90305-1 189495
    • (1977) Virology , vol.76 , pp. 313-330
    • Deng, C.T.1    Stehelin, D.2    Bishop, J.M.3    Varmus, H.E.4
  • 105
    • 0035823484 scopus 로고    scopus 로고
    • Functional analysis of Csk and CHK kinases in breast cancer cells
    • 10.1074/jbc.M104209200 11445575
    • Functional analysis of Csk and CHK kinases in breast cancer cells. Bougeret C, Jiang SX, Keydar I, Avraham H, J Biol Chem 2001 276 33711 33720 10.1074/jbc.M104209200 11445575
    • (2001) J Biol Chem , vol.276 , pp. 33711-33720
    • Bougeret, C.1    Jiang, S.X.2    Keydar, I.3    Avraham, H.4
  • 106
    • 0032735234 scopus 로고    scopus 로고
    • Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa
    • 10.1002/(SICI)1097-0215(19991126)83:5<579: AID-IJC1>3.0.CO;2-R 10521789
    • Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. Chen WS, Kung HJ, Yang WK, Lin WC, Int J Cancer 1999 83 579 584 10.1002/(SICI)1097- 0215(19991126)83:5<579::AID-IJC1>3.0.CO;2-R 10521789
    • (1999) Int J Cancer , vol.83 , pp. 579-584
    • Chen, W.S.1    Kung, H.J.2    Yang, W.K.3    Lin, W.C.4
  • 107
    • 34548260422 scopus 로고    scopus 로고
    • CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation
    • 10.1016/j.yexmp.2007.04.008 17599831
    • CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation. Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S, Exp Mol Pathol 2007 83 207 215 10.1016/j.yexmp.2007.04.008 17599831
    • (2007) Exp Mol Pathol , vol.83 , pp. 207-215
    • Subramaniam, V.1    Vincent, I.R.2    Gardner, H.3    Chan, E.4    Dhamko, H.5    Jothy, S.6
  • 109
    • 44849134528 scopus 로고    scopus 로고
    • Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model
    • 10.1158/0008-5472.CAN-07-2997 18451159
    • Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Park SI, Zhang J, Phillips KA, Araujo JC, Najjar AM, Volgin AY, Gelovani JG, Kim SJ, Wang Z, Gallick GE, Cancer Res 2008 68 3323 3333 10.1158/0008-5472.CAN-07-2997 18451159
    • (2008) Cancer Res , vol.68 , pp. 3323-3333
    • Park, S.I.1    Zhang, J.2    Phillips, K.A.3    Araujo, J.C.4    Najjar, A.M.5    Volgin, A.Y.6    Gelovani, J.G.7    Kim, S.J.8    Wang, Z.9    Gallick, G.E.10
  • 110
    • 79955632219 scopus 로고    scopus 로고
    • Differential transformation capacity of Src family kinases during the initiation of prostate cancer
    • 10.1073/pnas.1103904108 21464326
    • Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON, Proc Natl Acad Sci USA 2011 108 6579 6584 10.1073/pnas.1103904108 21464326
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6579-6584
    • Cai, H.1    Smith, D.A.2    Memarzadeh, S.3    Lowell, C.A.4    Cooper, J.A.5    Witte, O.N.6
  • 111
    • 0141994778 scopus 로고    scopus 로고
    • The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged
    • 10.1074/jbc.M304685200 12881526
    • The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged. Ding Q, Stewart J, Olman MA, Klobe MR, Gladson CL, J Biol Chem 2003 278 39882 39891 10.1074/jbc.M304685200 12881526
    • (2003) J Biol Chem , vol.278 , pp. 39882-39891
    • Ding, Q.1    Stewart, J.2    Olman, M.A.3    Klobe, M.R.4    Gladson, C.L.5
  • 112
    • 28344454000 scopus 로고    scopus 로고
    • Molecular classification and molecular forecasting of breast cancer: Ready for clinical application?
    • 10.1200/JCO.2005.03.3845 16145060
    • Molecular classification and molecular forecasting of breast cancer: ready for clinical application? Brenton JD, Carey LA, Ahmed AA, Caldas C, J Clin Oncol 2005 23 7350 7360 10.1200/JCO.2005.03.3845 16145060
    • (2005) J Clin Oncol , vol.23 , pp. 7350-7360
    • Brenton, J.D.1    Carey, L.A.2    Ahmed, A.A.3    Caldas, C.4


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