Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport

Journal of Clinical Investigation

Volumn 99, Issue 2, 1997, Pages 220-227

  De Franceschi, Lucia ^a   Fumagalli, Laura ^a   Olivieri, Oliviero ^a   Corrocher, Roberto ^a   Lowell, Clifford A ^b   Berton, Giorgio ^a,c  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Istituto di Patologia Generale   (Italy)

Author keywords

erythrocyte; gene knockout; membrane transport; phosphorylation; tyrosine kinase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BUMETANIDE; CHLORIDE ION; OKADAIC ACID; OUABAIN; POTASSIUM ION; PROTEIN TYROSINE KINASE; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL ISOLATION; CHLORIDE TRANSPORT; CONTROLLED STUDY; ENZYME ASSAY; ENZYME DEFICIENCY; ERYTHROCYTE; FEMALE; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RETICULOCYTOSIS; SODIUM TRANSPORT;

EID: 0031030067     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119150     Document Type: Article

References (50)

1. Lauf, P.K., J. Bauer, N.C. Adragna, H. Fujise, A.M.M. Zade-Oppen, K. Hai-Ryu, and E. Delpire. 1992. Erythrocyte K/Cl cotransport: properties and regulation. Am. J. Physiol. 263:C917-C932.
2. Brugnara, C. 1994. Cation homeostasis. In Sickle Cell Disease: Basic Principles and Clinical Practice. S.H. Embury, R.P. Hebbel, N. Mohandas, and M.H. Steinberg, editors. Raven Press, Ltd., New York. 173-194.
3. Brugnara, C. 1989. Characteristics of the volume and chloride dependent K transport in human erythrocytes homozygous for hemoglobin C. J. Membr. Biol. 111:69-81.
4. Brugnara, C., H.F. Bunn, and D.C. Tosteson. 1989. Ion content and transport and the regulation of volume in sickle cells. Ann. NY. Acad. Sci. 565: 96-103.
5. Brugnara, C., T. Van Ha, and D.C. Tosteson. 1988. Properties of K transport in resealed human erythrocyte ghosts. Am. J. Physiol. 255:C346-C356.
6. Canessa, M., M.E. Fabry, N. Blumenfeld, and R.L. Nagel. 1987. Volume stimulated Cl dependent K efflux is highly expressed in young human red cells containing normal hemoglobin or Hb S. J. Membr. Biol. 97:97-105.
7. Olivieri, O., L. De Franceschi, M.D. Capellini, D. Girelli, R. Corrocher, and C. Brugnara. 1994. Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias. Blood. 84:315-320.
8. Brugnara, C., and L. De Franceschi. 1993. Effect of cell age and phenylhydrazine on the cation transport properties. J. Cell. Physiol. 154:271-280.
9. Hall, A.C., and J.C. Ellory. 1986. Evidence for the presence of a volume-sensitive K/Cl cotransport in "young" human red cells. Biochim. Biophys. Acta. 858:317-320.
10. Armsby, C.C., C. Brugnara, and S.L. Alper. 1995. Cation transport in mouse erythrocytes: role of K/Cl cotransport in regulatory volume decrease. Am. J. Physiol. 268:C894-C902.
11. De Franceschi, L., Y. Beuzard, and C. Brugnara. 1995. Sulfhydryl oxidation and activation of red cell K/Cl cotransport in the transgenic SAD mouse. Am. J. Physiol. 268:C899-C906.
12. Olivieri, O., M. Bonollo, S. Friso, D. Girelli, R. Corrocher, and L. Vettore. 1993. Activation of K/Cl cotransport in human erythrocytes exposed to oxidative agent. Biochim. Biophys. Acta. 1176:37-42.
13. Jennings, M.L., and N. Al-Rohil. 1990. Kinetics of activation and inactivation of swelling-stimulated K/Cl transport. The volume sensitive parameter is the rate constant for inactivation. J. Gen. Physiol. 95:1021-1040.
14. Dunham, P.B. 1990. K/Cl cotransport in mammalian erythrocytes. In Regulation of Potassium Transport Across Biological Membranes. L. Reuss, J.M. Russel, and G. Szabo, editors, University of Texas Press, Austin, TX. 331-360.
15. Jennings, M.L., and R.K. Schulz. 1991. Okadaic acid inhibition of K/Cl cotransport. Evidence that protein dephosphorilation is necessary for activation of transport by either cell swelling or N-ethylmaleimide. J. Gen. Physiol. 97:799-818.
16. Kaji, D.M., and Y. Tsukitani. 1991. Role of protein phosphatase in activation of K/Cl cotransport in human erythrocytes. Am. J. Physiol. 260:C178-C182.
17. Bize, I., and P.B. Dunham. 1994. Staurosporine, a protein kinase inhibitor, activates K/Cl cotransport in LK sheep eryhtrocytes. Am. J. Physiol. 266: C759-C770.
18. Kaji, D.M. 1986. Volume sensitive K transport in human erythrocytes. J. Gen. Physiol. 88:719-738.
19. Starke, L.C., and M.L. Jennings. 1993. K-Cl cotransport in rabbit red cells: further evidence for regulation by protein phosphatase 1. Am. J. Physiol. 264:C118-C124.
20. 2 activates red blood cell K-Cl cotransport via stimulation of a phosphatase. Am. J. Physiol. 269:C849-C855.
21. syk. J. Biol. Chem. 269:955-959.
22. Bolen, J.B., R.B. Rowley, C. Spana, and A.Y. Tsygankov. 1992. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 6:3403-3409.
23. Bolen, J.B. 1995. Protein tyrosine kinases in the initiation of antigen receptor signaling. Curr. Op. Immunol. 7:306-311.
24. Lowell, C.A., and P. Soriano. 1996. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev. 10:1845-1857.
25. Qintrell, N., R. Lebo, H. Varmus, J.M. Bishop, M.J. Pettenati, M.M. Le Beau, M.O. Diaz, and J.D. Rowley. 1987. Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed by hemopoietic cells. Mol. Cell. Biol. 7:2267-2275.
26. lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc. Natl. Acad. Sci. USA. 86:6538-6542.
27. Link, D.C., and M. Zutter. 1995. The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo. Blood. 85:472-479.
28. fgr is expressed in murine splenic B cells and is activated in response to antigen-receptor cross-linking. J. Immunol. 154:3234-3244.
29. Lowell, C.A., P. Soriano, and H.E. Varmus. 1994. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Gene Dev. 8:387-398.
30. c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133:895-910.
31. Berton, G., L. Fumagalli, C. Laudanna, and C. Sorio. 1994. β2 integrin-dependent protein tyrosine phosphorylation and activation of the Fgr protein tyrosine kinase in human neutrophils. J. Cell Biol. 126:1111-1121.
32. Benos, I., and D.C. Tosteson. 1980. Cation movements across mouse red blood cells. Biochim. Biophys. Acta. 601:167-179.
33. De Franceschi, L., P. Rouyer-Fessard, S.L. Alper, H. Jouault, C. Brugnara, and Y. Beuzard. 1966. Combination therapy of erythropoietin, hydroxyurea and clotrimazole in a β thalassemic mouse: a model for human therapy. Blood. 87:1188-1195.
34. Danon, D., and Y. Marikovsky. 1964. Determination of density distribution of red cell population. J. Clin. Lab. Med. 64:668-674.
35. Lauf, P.K., and N.C. Adragna. 1995. Temperature-induced functional deocclusion of thiols inhibitory for sheep erythrocyte K-Cl cotransport. Am. J. Physiol. 269:C1167-C1175.
36. Armsby, C.C., C. Brugnara, and S.L. Alper. 1995. Cation transport in mouse erythrocytes: role of KCl cotransport in regulatory volume decrease. Am. J. Physiol. C849-C902.
37. Krarup, T., and P.B. Dunham. 1996. Reconstitution of calyculin-inhibited K-Cl cotransport in dog erythrocyte ghosts by exogenous PP-1. Am. J. Physiol. 270:C898-C902.
38. Lauf, P.K. 1983. Thiol-dependent passive K/Cl transport in sheep red cells. I. Dependence on chloride and external K+ [Rb+] ions. J. Membr. Biol. 73:237-246.
39. Sattil, S.J., M.H. Ginsberg, and J.S. Brugge. 1994. Adhesive signaling in platelets. Curr. Op. Cell Biol. 6:695-704.
40. + sheep. J. Cell Physiol. 116:35-44.
41. Nakano, H., E. Kobayashi, I. Takahashi, T. Tamaoki, Y. Kuzuu, and H. Iba. 1987. Staurosporine inhibits tyrosine-specific protein kinase activity of rous sarcoma virus transforming protein p60. J. Antibiot. (Tokyo). 40:706-708.
42. Yamaguchi, Y.F., and S. Kathuria. 1988. Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-I receptor. Biochem. Biophys. Res. Commun. 157:955-962.
43. Secrist, J.P., I. Sehgal, G. Powis, and R.T. Abraham. 1990. Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by Staurosporine. J. Biol. Chem. 265:20394-20400.
44. Badwey, J.A., R.W. Erickson, and J.T. Curnutte. 1991. Staurosporine inhibits the soluble and membrane-bound protein tyrosine kinases of human neutrophils. Biochem. Biophys. Res. Commun. 178:423-429.
45. v-Src. Proc. Natl. Acad. Sci. USA. 83:207-211.
46. Ulug, E.T., A.J. Cartwright, and S. Courtneidge. 1992. Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase. J. Virol. 66:1458-1467.
47. Chen, J., B.L. Martin, and D.L. Brautigan. 1992. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science (Wash. DC). 257:1261-1264.
48. Chen, J., S. Parsons, and D.L. Brautigan. 1994. Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. J. Biol. Chem. 269:7957-7962.
49. Joiner, C.A., R.S. Franco, M. Jiang, M.S. Franco, J.E. Barker, and S.E. Lux. 1995. Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons. Blood. 86:4307-4314.
50. Tripodi, G., F. Valtorta, L. Torielli, E. Chieregatti, S. Salardi, L. Trusolino, A. Menegon, P. Ferrari, P.C. Marchisio, and G. Bianchi. 1996. Hypertension-associated point mutations in the adducin α and β subunits affect actin cytoskeleton and ion transport. J. Clin. Invest. 97:2815-2822.