Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway

Blood

Volumn 91, Issue 10, 1998, Pages 3734-3745

  Chin, Hiroshi ^b   Arai, Ayako ^b   Wakao, Hiroshi ^b   Kamiyama, Ryuichi ^b   Miyasaka, Nobuyuki ^b   Miura, Osamu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; ERYTHROPOIESIS; GROWTH REGULATION; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0032525115     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.10.3734.3734_3734_3745     Document Type: Article

References (53)

1. Krantz SB: Erythropoietin. Blood 77:419, 1991
2. Ihle JN, Quelle FW, Miura O: Signal transduction through the receptor for erythropoietin. Semin Immunol 5:375, 1993
3. Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF: Structure, function, and activation of the erythropoietin receptor. Blood 81:2223, 1993
4. Miura O, D'Andrea A, Kabat D, Ihle JN: Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis. Mol Cell Biol 11:4895, 1991
5. Miura O, Cleveland JL, Ihle JN: Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors. Mol Cell Biol 13:1788, 1993
6. Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, Ihle JN: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227, 1993
7. Miura O, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N: Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo. Blood 84:1501, 1994
8. Ihle JN: Cytokine receptor signalling. Nature 377:591, 1995
9. Ihle JN: STATs: Signal transducers and activators of transcription. Cell 84:331, 1996
10. Miura O, Nakamura N, Ihle JN, Aoki N: Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor. J Biol Chem 269:614, 1994
11. Miura O, Miura Y, Nakamura N, Quelle FW, Witthuhn BA, Ihle JN, Aoki N: Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. Blood 84:4135, 1994
12. Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, Toyoshima K: The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol 7:237, 1987
13. Yi TL, Bolen JB, Ihle JN: Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol Cell Biol 11:2391, 1991
14. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G: Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. J Clin Invest 99:220, 1997
15. Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR: Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83:301, 1995
16. Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mori S, Watanabe T, Yamamoto T: Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3:549, 1995
17. Torigoe T, O'Connor R, Santoli D, Reed JC: Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines. Blood 80:617, 1992
18. Corey S, Eguinoa A, Puyana TK, Bolen JB, Cantley L, Mollinedo F, Jackson TR, Hawkins PT, Stephens LR: Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 12:2681, 1993
19. Anderson SM, Jorgensen B: Activation of src-related tyrosine kinases by IL-3. J Immunol 155:1660, 1995
20. Rao P, Mufson RA: A membrane proximal domain of the human interleukin-3 receptor beta c subunit that signals DNA synthesis in NIH 3T3 cells specifically binds a complex of Src and Janus family tyrosine kinases and phosphatidylinositol 3-kinase. J Biol Chem 270:6886, 1995
21. Pazdrak K, Schreiber D, Forsythe P, Justement L, Alam R: The intracellular signal transduction mechanism of interleukin 5 in eosinophils: The involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway. J Exp Med 181:1827, 1995
22. Yousefi S, Hoessli DC, Blaser K, Mills GB, Simon HU: Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J Exp Med 183:1407, 1996
23. Miyajima A, Mui AL, Ogorochi T, Sakamaki K: Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82:1960, 1993
24. Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ: Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci USA 91:4683, 1994
25. Varmus HE, Lowell CA: Cancer genes and hematopoiesis. Blood 83:5, 1994
26. Tilbrook PA, Ingley E, Williams JH, Hibbs ML, Klinken SP: Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO J 16:1610, 1997
27. Chiba S, Takaku F, Tange T, Shibuya K, Misawa C, Sasaki K, Miyagawa K, Yazaki Y, Hirai H: Establishment and erythroid differentiation of a cytokine-dependent human leukemic cell line F-36: A parental line requiring granulocyte-macrophage colony-stimulating factor or interleukin-3, and a subline requiring erythropoietin. Blood 78:2261, 1991
28. D'Andrea AD, Lodish HF, Wong GG: Expression cloning of the murine erythropoietin receptor. Cell 57:277, 1989
29. Gouilleux F, Pallard C, Dusanter FI, Wakao H, Haldosen LA, Norstedt G, Levy D, Groner B: Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J 14:2005, 1995
30. Silvennoinen O, Witthuhn BA, Quelle FW, Cleveland JL, Yi T, Ihle JN: Structure of the JAK2 protein kinase and its role in IL-3 signal transduction. Proc Natl Acad Sci USA 90:8429, 1993
31. Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN: Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 16:1622, 1996
32. Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 13:2182, 1994
33. IL3. Blood 89:4327, 1997
34. 125I-Epo cross-linking in cells expressing wildtype or mutant receptors. Blood 81:1739, 1993
35. Yi T, Zhang J, Miura O, Ihle JN: Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: Identification of potential binding sites. Blood 85:87, 1995
36. Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle JN, Miura O: Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. Blood 88:4415, 1996
37. Miura O, Ihle JN: Dimer- and oligomerization of the erythropoietin receptor by disulfide bond formation and significance of the region near the WSXWS motif in intracellular transport. Arch Biochem Biophys 306:200, 1993
38. Hatakeyama M, Kono T, Kobayashi N, Kawahara A, Levin SD, Perlmutter RM, Taniguchi T: Interaction of the IL-2 receptor with the src-family kinase p56lck: Identification of novel intermolecular association. Science 252:1523, 1991
39. Torigoe T, Saragovi HU, Reed JC: Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line. Proc Natl Acad Sci USA 89:2674, 1992
40. Kobayashi N, Kono T, Hatakeyama M, Minami Y, Miyazaki T, Perlmutter RM, Taniguchi T: Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: Implications for redundancy and pleiotropism in cytokine signal transduction. Proc Natl Acad Sci USA 90:4201, 1993
41. Yoshimura A, D'Andrea AD, Lodish HF: Friend spleen focusforming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. Proc Natl Acad Sci USA 87:4139, 1990
42. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, Neel BG, Birge RB, Fajardo JE, Chou MM, Hanafusa H, Schaffhausen B, Cantley LC: SH2 domains recognize specific phosphopeptide sequences. Cell 72:767, 1993
43. Damen JE, Cutler RL, Jiao H, Yi T, Krystal G: Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. J Biol Chem 270:23402, 1995
44. Klingmüller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF: Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci USA 94:3016, 1997
45. Jucker M, Feldman RA: Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/ macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase. J Biol Chem 270:27817, 1995
46. Ptasznik A, Prossnitz ER, Yoshikawa D, Smrcka A, Traynor KA, Bokoch GM: A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils. J Biol Chem 271:25204, 1996
47. Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Gambier JC: Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidyl-inositol 3-kinase. Mol Cell Biol 13:5877, 1993
48. Pleiman CM, Hertz WM, Cambier JC: Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263:1609, 1994
49. Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter SC, Schwartz J, Jove R: Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81, 1995
50. Cao X, Tay A, Guy GR, Tan YH: Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol 16:1595, 1996
51. Parsons JT, Parsons SJ: Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways. Curr Opin Cell Biol 9:187, 1997
52. Chaturvedi P, Sharma S, Reddy EP: Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol Cell Biol 17:3295, 1997
53. Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, White MF, Platanias LC: Interaction of p59fyn with interferon-activated Jak kinases. Biochem Biophys Res Commun 235:83, 1997