New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 17, 2012, Pages 5296-5304

  Lohou, Elodie ^a   Sopkova De Oliveira Santos, Jana ^a   Schumann Bard, Pascale ^b   Boulouard, Michel ^b   Stiebing, Silvia ^a   Rault, Sylvain ^a   Collot, Valérie ^a  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

^b UNIVERSITÉ DE CAEN   (France)

Author keywords

4 Substituted indazoles; 7 Nitroindazole; Binding mode in the nNOS active site; Microwave promoted palladium catalysed cyanation; N Alkylation; Neuronal nitric oxide synthase inhibitors

Indexed keywords

1 (TETRAHYDRO 2H PYRAN 2 YL) 1H INDAZOLE 4 CARBONITRILE; 1 (TETRAHYDRO 2H PYRAN 2 YL) 1H INDAZOLE 5 CARBONITRILE; 1 ETHYL 4 BROMO 1H INDAZOLE; 1 ETHYL 4 NITRO 1H INDAZOLE; 1 METHYL 4 BROMO 1H INDAZOLE; 1 METHYL 4 NITRO 1H INDAZOLE; 1H INDAZOLE 4 CARBONITRILE; 2 ETHYL 4 BROMO 1H INDAZOLE; 2 ETHYL 4 NITRO 1H INDAZOLE; 2 METHYL 4 BROMO 1H INDAZOLE; 2 METHYL 4 NITRO 1H INDAZOLE; 4 BROMO 1 (TETRAHYDRO 2H PYRAN 2 YL) 1H INDAZOLE; 4 BROMO 1H INDAZOLE; 4 NITRO 1H INDAZOLE; 5 BROMO 1 (TETRAHYDRO 2H PYRAN 2 YL) 1H INDAZOLE; INDAZOLE DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; NONHUMAN; RAT;

BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE I; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864995412     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.025     Document Type: Article

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