1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5234-5238

  Maddaford, Shawn ^a   Renton, Paul ^a   Speed, Joanne ^a   Annedi, Subhash C ^a   Ramnauth, Jailall ^a   Rakhit, Suman ^a   Andrews, John ^a   Mladenova, Gabriela ^a   Majuta, Lisa ^b   Porreca, Frank ^b  

^a NeurAxon Inc   (Canada)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

1,6 Disubstitued indole derivatives; Nitric oxide; Nitric oxide synthase; Nitric oxide synthase inhibitors; Selective neuronal nitric oxide synthase inhibitors

Indexed keywords

ANTIINFLAMMATORY AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDOLE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HYPERESTHESIA; INFLAMMATION; MIGRAINE; NONHUMAN; PHARMACOPHORE; RAT; STEREOCHEMISTRY;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INDOLES; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80051948720     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.042     Document Type: Article

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