A facile microwave-assisted palladium-catalyzed cyanation of aryl chlorides

Tetrahedron Letters

Volumn 47, Issue 19, 2006, Pages 3303-3305

  Chobanian, Harry R ^a   Fors, Brett P ^a   Lin, Linus S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2',6' DIMETHOXYBIPHENYL)DICYCLOHEXYLPHOSPHINE; CHLORIDE; CYANIDE; NITRILE; PALLADIUM COMPLEX; PHOSPHINE DERIVATIVE; TRIS(DIBENZYLIDENE ACETONE)DIPALLADIUM; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CATALYSIS; CATALYST; CYANATION; MICROWAVE RADIATION;

PHOS;

EID: 33645807187     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.03.026     Document Type: Article

References (13)

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11. 2 for 10 min before being heated to 120 °C for 1 h. Once complete, the reaction was purified as described above.
12. S-Phos ligand was purchased from Strem Chemicals Inc., 7 Mulliken Way, Dexter Industrial Park, Newburyport, MA 01950.
13. 3 and 2 mol % S-Phos for the conversion of 1 to 2 without any significant change in yield or reaction time.