3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1980-1984

  Annedi, Subhash C ^a   Maddaford, Shawn P ^a   Ramnauth, Jailall ^a   Renton, Paul ^a   Speed, Joanne ^a   Rakhit, Suman ^a   Andrews, John S ^a   Porreca, Frank ^b  

^a NeurAxon Inc   (Canada)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

3,5 Disubstituted indole derivatives; Migraine; Neuropathic pain; Nitric oxide; Selective neuronal nitric oxide synthase inhibitors

Indexed keywords

2 FURANYL AMIDINE; 2 THIOPHENE AMIDINE; 3,5 DISUBSTITUTED INDOLE DERIVATIVE; CYTOCHROME P450; INDOLE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; N METHYLPIPERIDINE; NEURONAL NITRIC OXIDE SYNTHASE INHIBITOR; NITRIC OXIDE SYNTHASE INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; HYPERALGESIA; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; RAT; SPINAL NERVE; THERMAL HYPERALGESIA;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYPERALGESIA; INDOLES; MIGRAINE DISORDERS; NEURALGIA; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; RATS; SPINAL NERVES;

EID: 84857369766     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.031     Document Type: Article

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