Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 9, 2006, Pages 3185-3198

  Litzinger, Elizabeth A ^a   Martásek, Pavel ^b   Roman, Linda J ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Absorption difference spectra; Enzyme inactivation; Enzyme inhibition; Heme ligands; Heme binders; Nitric oxide synthase; Nitric oxide synthase inhibition

Indexed keywords

AMIDINE; ARGININE DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME; IMIDAZOLE DERIVATIVE; IRON; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; THIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE;

ABSORPTION SPECTROSCOPY; ARTICLE; COMPUTER MODEL; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; INHIBITION KINETICS;

ANIMALS; ARGININE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; HEME; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE; RATS; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33644979237     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.043     Document Type: Article

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