Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 17, 2009, Pages 6180-6187

  Claramunt, Rosa M ^a   López, Concepción ^a   Pérez Medina, Carlos ^a   Pérez Torralba, Marta ^a   Elguero, José ^b   Escames, Germaine ^c   Acuña Castroviejo, Darío ^c,d  

^a UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

^d HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

Author keywords

Fluorine pharmacophore; Indazoles; NOS I; NOS II

Indexed keywords

1(2),5,6,7 TETRAHYDRO 4H INDAZOL 4 ONE; 3 BROMO 7 NITRO 1H INDAZOLE; 3 METHYL 1(2),5,6,7 TETRAHYDRO 4H INDAZOL 4 ONE; 3 METHYL 4,5,6,7 TETRAFLUORO 1H INDAZOLE; 3 TRIFLUOROMETHYL 4,5,6,7 TETRAFLUORO 1H INDAZOLE; 3,6,6 TRIMETHYL 1(2),5,6,7 TETRAHYDRO 4H INDAZOL 4 ONE; 6,6 DIMETHYL 1(2),5,6,7 TETRAHYDRO 4H INDAZOL 4 ONE; 7 NITRO 1H INDAZOLE; INDAZOLE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NEUROPROTECTION;

ANIMALS; ENZYME INHIBITORS; HALOGENATION; HEME; INDAZOLES; MALE; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR;

EID: 68649084717     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.067     Document Type: Article

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