N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6495-6499

  MacCallini, Cristina ^a   Patruno, Antonia ^a   Lannutti, Fabio ^a   Ammazzalorso, Alessandra ^a   De Filippis, Barbara ^a   Fantacuzzi, Marialuigia ^a   Franceschelli, Sara ^a   Giampietro, Letizia ^a   Masella, Simona ^a   Felaco, Mario ^a   Re, Nazzareno ^a   Amoroso, Rosa ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

2 Methylimidazole derivatives; Acetamidines; Isoform selectivity; Nitric oxide synthase (NOS); NOS inhibitors

Indexed keywords

ACETAMIDINE DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMIDAZOLE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; N (3 (AMINOMETHYL) BENZYL)ACETAMIDINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ACETAMIDES; ENZYME INHIBITORS; IMIDAZOLES; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II;

EID: 77958077660     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.059     Document Type: Article

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