Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 18, 2007, Pages 6096-6108

  Erdal, Erik P ^a   Martásek, Pavel ^b   Roman, Linda J ^b   Silverman, Richard B ^a  

^a Center for Drug Discovery and Chemical Biology ^*  (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Enzyme inhibitor; Hydroxyethylene isostere; Nitric oxide; Nitric oxide synthase; nNOS inhibitor

Indexed keywords

AMIDE; DIPEPTIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ETHYLENE DERIVATIVE; HYDROXYETHYLENE ISOSTERE; INDUCIBLE NITRIC OXIDE SYNTHASE; N (DIAMINOHYDROXYNONYL)NITROGUANIDINE; N (DIAMINOHYDROXYOCTYL)NITROGUANIDINE; N(G) NITROARGININE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNITY; NERVE DEGENERATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; ANIMALS; CATTLE; DIPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; ETHYLENES; MACROPHAGES; MICE; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447642352     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.038     Document Type: Article

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