Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 11, 2008, Pages 5962-5973

  Cottyn, Betty ^a   Acher, Francine ^b   Ramassamy, Booma ^b   Alvey, Luke ^a   Lepoivre, Michel ^c   Frapart, Yves ^b   Stuehr, Dennis ^d   Mansuy, Daniel ^b   Boucher, Jean Luc ^b   Vichard, Dominique ^a  

^a UNIVERSITÉ DE VERSAILLES SAINT QUENTIN EN YVELINES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

7 Nitroindazole; Inhibitors; Nitric oxide synthase; Substituted indazoles

Indexed keywords

1H INDAZOLE 7 CARBONITRILE; 3 BROMO 1H INDAZOLE 7 CARBONITRILE; 7 NITRO 1H INDAZOLE; BROMINE; HEME; INDAZOLE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PHASE TRANSITION; X RAY ANALYSIS;

EID: 44449090492     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.056     Document Type: Article

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