A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors

Acta Crystallographica Section D: Biological Crystallography

Volumn 67, Issue 3, 2011, Pages 156-166

  Schulz, Michle N ^a   Fanghänel, Jörg ^a   Schäfer, Martina ^a   Badock, Volker ^a   Briem, Hans ^a   Boemer, Ulf ^a   Nguyen, Duy ^a   Husemann, Manfred ^a   Hillig, Roman C ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

cinnamic acid; fragments; inhibitors; Pim 1; serine threonine kinases

Indexed keywords

CINNAMIC ACID DERIVATIVE; LIGAND; PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; IC 50; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

CINNAMATES; CRYSTALLOGRAPHY, X-RAY; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-PIM-1; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 79952269579     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444910054144     Document Type: Article

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