메뉴 건너뛰기




Volumn 53, Issue 9, 2012, Pages 1738-1754

PPAR-γ as a therapeutic target in cardiovascular disease: Evidence and uncertainty

Author keywords

Atherosclerosis; Diabetes; Fatty acids; Insulin resistance; Peroxisome proliferator activated receptor gamma; Randomized clinical trials

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ALEGLITAZAR; BALAGLITAZONE; FATTY ACID; FIBRIC ACID DERIVATIVE; GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; GLITAZAR; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMIGLITAZAR; ION CHANNEL; LIPOPROTEIN; METFORMIN; MURAGLITAZAR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PLACEBO; RAGAGLITAZAR; RIVOGLITAZONE; ROSIGLITAZONE; SULFONYLUREA; TESAGLITAZAR; TROGLITAZONE; UNCLASSIFIED DRUG;

EID: 84864864825     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R024505     Document Type: Review
Times cited : (60)

References (217)
  • 3
    • 34547431645 scopus 로고    scopus 로고
    • Adipose tissue expandability in the maintenance of metabolic homeostasis
    • Gray, S. L., and A. J. Vidal-Puig. 2007. Adipose tissue expandability in the maintenance of metabolic homeostasis. Nutr. Rev. 65: S7-S12.
    • (2007) Nutr. Rev. , vol.65
    • Gray, S.L.1    Vidal-Puig, A.J.2
  • 4
    • 33847006604 scopus 로고    scopus 로고
    • Review: Peroxisome proliferator- activated receptor gamma and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism
    • Sharma, A. M., and B. Staels. 2007. Review: peroxisome proliferator- activated receptor gamma and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism. J. Clin. Endocrinol. Metab. 92:386-395.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 386-395
    • Sharma, A.M.1    Staels, B.2
  • 6
    • 58049219012 scopus 로고    scopus 로고
    • Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
    • Hajer, G. R., T. W. van Haeften, and F. L. Visseren. 2008. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur. Heart J. 29:2959-2971.
    • (2008) Eur. Heart J. , vol.29 , pp. 2959-2971
    • Hajer, G.R.1    Van Haeften, T.W.2    Visseren, F.L.3
  • 7
    • 58149348524 scopus 로고    scopus 로고
    • All-cause mortality risk predictors in a preventive cardiology clinic cohort-examining diabetes and individual metabolic syndrome criteria: A PRECIS database study
    • Doshi, K. B., S. R. Kashyap, D. M. Brennan, B. M. Hoar, L. Cho, and B. J. Hoogwerf. 2009. All-cause mortality risk predictors in a preventive cardiology clinic cohort-examining diabetes and individual metabolic syndrome criteria: a PRECIS database study. Diabetes Obes. Metab. 11:102-108.
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 102-108
    • Doshi, K.B.1    Kashyap, S.R.2    Brennan, D.M.3    Hoar, B.M.4    Cho, L.5    Hoogwerf, B.J.6
  • 8
    • 4444222221 scopus 로고    scopus 로고
    • Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    • DOI 10.1161/01.CIR.0000140677.20606.0E
    • Malik, S., N. D. Wong, S. S. Franklin, T. V. Kamath, G. J. L'Italien, J. R. Pio, and G. R. Williams. 2004. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 110: 1245-1250. (Pubitemid 39202340)
    • (2004) Circulation , vol.110 , Issue.10 , pp. 1245-1250
    • Malik, S.1    Wong, N.D.2    Franklin, S.S.3    Kamath, T.V.4    L'Italien, G.J.5    Pio, J.R.6    Williams, G.R.7
  • 9
    • 0347716449 scopus 로고    scopus 로고
    • Association of the Metabolic Syndrome with History of Myocardial Infarction and Stroke in the Third National Health and Nutrition Examination Survey
    • DOI 10.1161/01.CIR.0000108926.04022.0C
    • Ninomiya, J. K., G. L'Italien, M. H. Criqui, J. L. Whyte, A. Gamst, and R. S. Chen. 2004. Association of the metabolic syndrome with history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey. Circulation. 109:42-46. (Pubitemid 38056019)
    • (2004) Circulation , vol.109 , Issue.1 , pp. 42-46
    • Ninomiya, J.K.1    L'Italien, G.2    Criqui, M.H.3    Whyte, J.L.4    Gamst, A.5    Chen, R.S.6
  • 11
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • Mayerson, A. B., R. S. Hundal, S. Dufour, V. Lebon, D. Befroy, G. W. Cline, S. Enocksson, S. E. Inzucchi, G. I. Shulman, and K. F. Petersen. 2002. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes. 51:797-802. (Pubitemid 34760191)
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3    Lebon, V.4    Befroy, D.5    Cline, G.W.6    Enocksson, S.7    Inzucchi, S.E.8    Shulman, G.I.9    Petersen, K.F.10
  • 14
    • 73949138029 scopus 로고    scopus 로고
    • The effect of rosiglitazone on insulin sensitivity and mid-thigh low-density muscle in patients with Type 2 diabetes
    • Nam, J. S., J. Y. Nam, J. S. Yoo, M. Cho, J. S. Park, C. W. Ahn, B. S. Cha, E. J. Lee, S. K. Lim, K. R. Kim, et al. 2010. The effect of rosiglitazone on insulin sensitivity and mid-thigh low-density muscle in patients with Type 2 diabetes. Diabet. Med. 27:30-36.
    • (2010) Diabet. Med. , vol.27 , pp. 30-36
    • Nam, J.S.1    Nam, J.Y.2    Yoo, J.S.3    Cho, M.4    Park, J.S.5    Ahn, C.W.6    Cha, B.S.7    Lee, E.J.8    Lim, S.K.9    Kim, K.R.10
  • 15
    • 52049098099 scopus 로고    scopus 로고
    • Pioglitazone and rosiglitazone: Effects of treatment with a thiazolidinedione on lipids and non conventional cardiovascular risk factors
    • Derosa, G., and S. A. Salvadeo. 2008. Pioglitazone and rosiglitazone: effects of treatment with a thiazolidinedione on lipids and non conventional cardiovascular risk factors. Curr. Clin. Pharmacol. 3:77-84.
    • (2008) Curr. Clin. Pharmacol. , vol.3 , pp. 77-84
    • Derosa, G.1    Salvadeo, S.A.2
  • 16
    • 0036076907 scopus 로고    scopus 로고
    • Metabolic and additional vascular effects of thiazolidinediones
    • Martens, F. M., F. L. Visseren, J. Lemay, E. J. de Koning, and T. J. Rabelink. 2002. Metabolic and additional vascular effects of thiazolidinediones. Drugs. 62:1463-1480. (Pubitemid 34804155)
    • (2002) Drugs , vol.62 , Issue.10 , pp. 1463-1480
    • Martens, F.M.A.C.1    Visseren, F.L.J.2    Lemay, J.3    De Koning, E.J.P.4    Rabelink, T.J.5
  • 17
    • 42149134825 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on adiponectin serum level: A meta-analysis
    • DOI 10.1111/j.1463-1326.2007.00755.x
    • Riera-Guardia, N., and D. Rothenbacher. 2008. The effect of thiazolidinediones on adiponectin serum level: a meta-analysis. Diabetes Obes. Metab. 10:367-375. (Pubitemid 351524284)
    • (2008) Diabetes, Obesity and Metabolism , vol.10 , Issue.5 , pp. 367-375
    • Riera-Guardia, N.1    Rothenbacher, D.2
  • 18
    • 79952337610 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-gamma in atherosclerosis: An update
    • Wang, N., R. Yin, Y. Liu, G. Mao, and F. Xi. 2011. Role of peroxisome proliferator-activated receptor-gamma in atherosclerosis: an update. Circ. J. 75:528-535.
    • (2011) Circ. J. , vol.75 , pp. 528-535
    • Wang, N.1    Yin, R.2    Liu, Y.3    Mao, G.4    Xi, F.5
  • 19
    • 74949126382 scopus 로고    scopus 로고
    • Endothelial and vascular muscle PPARgamma in arterial pressure regulation: Lessons from genetic interference and deficiency
    • Sigmund, C. D. 2010. Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension. 55:437-444.
    • (2010) Hypertension , vol.55 , pp. 437-444
    • Sigmund, C.D.1
  • 20
    • 39449102532 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature
    • DOI 10.1161/CIRCRESAHA.107.164384, PII 0000301220080215000007
    • Duan, S. Z., M. G. Usher, and R. M. Mortensen. 2008. Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ. Res. 102:283-294. (Pubitemid 351271648)
    • (2008) Circulation Research , vol.102 , Issue.3 , pp. 283-294
    • Duan, S.Z.1    Usher, M.G.2    Mortensen, R.M.3
  • 21
    • 53149142762 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: Novel pharmacological agents in the treatment of ischemia reperfusion injury
    • Giaginis, C., G. Tsourouflis, and S. Theocharis. 2008. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury. Curr. Mol. Med. 8:562-579.
    • (2008) Curr. Mol. Med. , vol.8 , pp. 562-579
    • Giaginis, C.1    Tsourouflis, G.2    Theocharis, S.3
  • 23
    • 21544466158 scopus 로고    scopus 로고
    • A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
    • DOI 10.2337/diacare.28.7.1547
    • Goldberg, R. B., D. M. Kendall, M. A. Deeg, J. B. Buse, A. J. Zagar, J. A. Pinaire, M. H. Tan, M. A. Khan, A. T. Perez, and S. J. Jacober. 2005. A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care. 28:1547-1554. (Pubitemid 40923063)
    • (2005) Diabetes Care , vol.28 , Issue.7 , pp. 1547-1554
    • Goldberg, R.B.1    Kendall, D.M.2    Deeg, M.A.3    Buse, J.B.4    Zagar, A.J.5    Pinaire, J.A.6    Tan, M.H.7    Khan, M.A.8    Perez, A.T.9    Jacober, S.J.10
  • 24
    • 41149157881 scopus 로고    scopus 로고
    • Thiazolidinedione drugs block cardiac KATP channels and may increase propensity for ischaemic ventricular fibrillation in pigs
    • Lu, L., M. J. Reiter, Y. Xu, A. Chicco, C. R. Greyson, and G. G. Schwartz. 2008. Thiazolidinedione drugs block cardiac KATP channels and may increase propensity for ischaemic ventricular fibrillation in pigs. Diabetologia. 51:675-685.
    • (2008) Diabetologia , vol.51 , pp. 675-685
    • Lu, L.1    Reiter, M.J.2    Xu, Y.3    Chicco, A.4    Greyson, C.R.5    Schwartz, G.G.6
  • 25
    • 79955898038 scopus 로고    scopus 로고
    • Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone
    • Hancox, J. C. 2011. Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone. Br. J. Pharmacol. 163:496-498.
    • (2011) Br. J. Pharmacol. , vol.163 , pp. 496-498
    • Hancox, J.C.1
  • 26
    • 84864450055 scopus 로고    scopus 로고
    • Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fi- Brillation in pigs
    • Sarraf, M., L. Lu, S. Ye, M. J. Reiter, C. R. Greyson, and G. G. Schwartz. 2012. Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fi- brillation in pigs. Cardiovasc. Drugs Ther. 26: 195-204.
    • (2012) Cardiovasc. Drugs Ther. , vol.26 , pp. 195-204
    • Sarraf, M.1    Lu, L.2    Ye, S.3    Reiter, M.J.4    Greyson, C.R.5    Schwartz, G.G.6
  • 27
    • 35848933241 scopus 로고    scopus 로고
    • Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of nondiabetic low-density lipoprotein receptor-null mice
    • DOI 10.1161/CIRCULATIONAHA.107.698852
    • Thorp, E., G. Kuriakose, Y. M. Shah, F. J. Gonzalez, and I. Tabas. 2007. Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of nondiabetic low-density lipoprotein receptor-null mice. Circulation. 116: 2182-2190. (Pubitemid 350060356)
    • (2007) Circulation , vol.116 , Issue.19 , pp. 2182-2190
    • Thorp, E.1    Kuriakose, G.2    Shah, Y.M.3    Gonzalez, F.J.4    Tabas, I.5
  • 28
    • 80055022338 scopus 로고    scopus 로고
    • Early atheroma-derived agonists of peroxisome proliferator-activated receptor-gamma trigger intramedial angiogenesis in a smooth muscle cell-dependent manner
    • Ho-Tin-Noé, B., D. J. Le, D. Gomez, L. Louedec, R. Vranckx, M. El-Bouchtaoui, L. Legres, O. Meilhac, and J. B. Michel. 2011. Early atheroma-derived agonists of peroxisome proliferator-activated receptor-gamma trigger intramedial angiogenesis in a smooth muscle cell-dependent manner. Circ. Res. 109:1003-1014.
    • (2011) Circ. Res. , vol.109 , pp. 1003-1014
    • Ho-Tin-Noé, B.1    Le, D.J.2    Gomez, D.3    Louedec, L.4    Vranckx, R.5    El-Bouchtaoui, M.6    Legres, L.7    Meilhac, O.8    Michel, J.B.9
  • 29
    • 73649126161 scopus 로고    scopus 로고
    • Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance
    • Amin, R. H., S. T. Mathews, H. S. Camp, L. Ding, and T. Leff. 2010. Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance. Am. J. Physiol. Endocrinol. Metab. 298:E28-E37.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298
    • Amin, R.H.1    Mathews, S.T.2    Camp, H.S.3    Ding, L.4    Leff, T.5
  • 33
    • 33645079389 scopus 로고    scopus 로고
    • Comparison of glycaemic control over 1 year with pioglitazone or gliclazide in patients with Type 2 diabetes
    • Perriello, G., S. Pampanelli, P. C. Di, and P. Brunetti. 2006. Comparison of glycaemic control over 1 year with pioglitazone or gliclazide in patients with Type 2 diabetes. Diabet. Med. 23: 246-252.
    • (2006) Diabet. Med. , vol.23 , pp. 246-252
    • Perriello, G.1    Pampanelli, S.2    Di, P.C.3    Brunetti, P.4
  • 35
    • 0038746876 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus
    • DOI 10.1016/S0149-2918(03)80068-1
    • Herz, M., D. Johns, J. Reviriego, L. D. Grossman, C. Godin, S. Duran, F. Hawkins, H. Lochnan, F. Escobar-Jimenez, P. A. Hardin, et al. 2003. A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus. Clin. Ther. 25:1074-1095. (Pubitemid 36532579)
    • (2003) Clinical Therapeutics , vol.25 , Issue.4 , pp. 1074-1095
    • Herz, M.1    Johns, D.2    Reviriego, J.3    Grossman, L.D.4    Godin, C.5    Duran, S.6    Hawkins, F.7    Lochnan, H.8    Escobar-Jimenez, F.9    Hardin, P.A.10    Konkoy, C.S.11    Tan, M.H.12
  • 36
    • 0036776903 scopus 로고    scopus 로고
    • Sensitivity effect of rosiglitazone on insulin and body composition in type 2 diabetic patients
    • Carey, D. G., G. J. Cowin, G. J. Galloway, N. P. Jones, J. C. Richards, N. Biswas, and D. M. Doddrell. 2002. Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients. [corrected] Obes. Res. 10:1008-1015. (Pubitemid 135688917)
    • (2002) Obesity Research , vol.10 , Issue.10 , pp. 1008-1015
    • Carey, D.G.1    Cowin, G.J.2    Galloway, G.J.3    Jones, N.P.4    Richards, J.C.5    Biswas, N.6    Doddrell, D.M.7
  • 37
  • 39
    • 33749015458 scopus 로고    scopus 로고
    • Acute coronary syndromes and diabetes: Is intensive lipid lowering beneficial? Results of the PROVE IT-TIMI 22 trial
    • DOI 10.1093/eurheartj/ehl220
    • Ahmed, S., C. P. Cannon, S. A. Murphy, and E. Braunwald. 2006. Acute coronary syndromes and diabetes: Is intensive lipid lowering beneficial? Results of the PROVE IT-TIMI 22 trial. Eur. Heart J. 27:2323-2329. (Pubitemid 44453576)
    • (2006) European Heart Journal , vol.27 , Issue.19 , pp. 2323-2329
    • Ahmed, S.1    Cannon, C.P.2    Murphy, S.A.3    Braunwald, E.4
  • 40
    • 25644434372 scopus 로고    scopus 로고
    • Relation of characteristics of metabolic syndrome to short-term prognosis and effects of intensive statin therapy after acute coronary syndrome: An analysis of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) trial
    • DOI 10.2337/diacare.28.10.2508
    • Schwartz, G. G., A. G. Olsson, M. Szarek, and W. J. Sasiela. 2005. Relation of characteristics of metabolic syndrome to short-term prognosis and effects of intensive statin therapy after acute coronary syndrome: an analysis of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) trial. Diabetes Care. 28:2508-2513. (Pubitemid 41384302)
    • (2005) Diabetes Care , vol.28 , Issue.10 , pp. 2508-2513
    • Schwartz, G.G.1    Olsson, A.G.2    Szarek, M.3    Sasiela, W.J.4
  • 41
    • 7544236092 scopus 로고    scopus 로고
    • Newly detected abnormal glucose tolerance: An important predictor of long-term outcome after myocardial infarction
    • DOI 10.1016/j.ehj.2004.09.021, PII S0195668X0400675X
    • Bartnik, M., K. Malmberg, A. Norhammar, A. Tenerz, J. Ohrvik, and L. Ryden. 2004. Newly detected abnormal glucose tolerance: an important predictor of long-term outcome after myocardial infarction. Eur. Heart J. 25:1990-1997. (Pubitemid 39486017)
    • (2004) European Heart Journal , vol.25 , Issue.22 , pp. 1990-1997
    • Bartnik, M.1    Malmberg, K.2    Norhammar, A.3    Tenerz, A.4    Ohrvik, J.5    Ryden, L.6
  • 42
  • 48
    • 33845546137 scopus 로고    scopus 로고
    • Non-esterified fatty acids and blood pressure elevation: A mechanism for hypertension in subjects with obesity/insulin resistance?
    • DOI 10.1038/sj.jhh.1002103, PII 1002103
    • Sarafidis, P. A., and G. L. Bakris. 2007. Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance? J. Hum. Hypertens. 21: 12-19. (Pubitemid 44921815)
    • (2007) Journal of Human Hypertension , vol.21 , Issue.1 , pp. 12-19
    • Sarafidis, P.A.1    Bakris, G.L.2
  • 49
    • 9444249274 scopus 로고    scopus 로고
    • Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells
    • DOI 10.2337/diabetes.53.12.3209
    • Staiger, H., K. Staiger, N. Stefan, H. G. Wahl, F. Machicao, M. Kellerer, and H. U. Haring. 2004. Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes. 53:3209-3216. (Pubitemid 39564497)
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3209-3216
    • Staiger, H.1    Staiger, K.2    Stefan, N.3    Wahl, H.G.4    Machicao, F.5    Kellerer, M.6    Haring, H.-U.7
  • 51
    • 0033944950 scopus 로고    scopus 로고
    • Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production
    • Steinberg, H. O., G. Paradisi, G. Hook, K. Crowder, J. Cronin, and A. D. Baron. 2000. Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes. 49: 1231-1238. (Pubitemid 30439100)
    • (2000) Diabetes , vol.49 , Issue.7 , pp. 1231-1238
    • Steinberg, H.O.1    Paradisi, G.2    Hook, G.3    Crowder, K.4    Cronin, J.5    Baron, A.D.6
  • 53
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • Samuel, V. T., K. F. Petersen, and G. I. Shulman. 2010. Lipid-induced insulin resistance: unravelling the mechanism. Lancet. 375:2267-2277.
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 54
    • 77954956697 scopus 로고    scopus 로고
    • Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance
    • Savage, D. B., and R. K. Semple. 2010. Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance. Curr. Opin. Lipidol. 21:329-336.
    • (2010) Curr. Opin. Lipidol. , vol.21 , pp. 329-336
    • Savage, D.B.1    Semple, R.K.2
  • 55
    • 0028106069 scopus 로고
    • Lipids and cardiac arrhythmia
    • DOI 10.1016/0163-7827(94)90023-X
    • Charnock, J. S. 1994. Lipids and cardiac arrhythmia. Prog. Lipid Res. 33:355-385. (Pubitemid 24243352)
    • (1994) Progress in Lipid Research , vol.33 , Issue.4 , pp. 355-385
    • Charnock, J.S.1
  • 56
    • 36248992793 scopus 로고    scopus 로고
    • Elevated plasma free fatty acids predict sudden cardiac death: A 6.85-year follow-up of 3315 patients after coronary angiography
    • DOI 10.1093/eurheartj/ehm343
    • Pilz, S., H. Scharnagl, B. Tiran, B. Wellnitz, U. Seelhorst, B. O. Boehm, and W. Marz. 2007. Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography. Eur. Heart J. 28:2763-2769. (Pubitemid 350135527)
    • (2007) European Heart Journal , vol.28 , Issue.22 , pp. 2763-2769
    • Pilz, S.1    Scharnagl, H.2    Tiran, B.3    Wellnitz, B.4    Seelhorst, U.5    Boehm, B.O.6    Marz, W.7
  • 57
    • 0023189066 scopus 로고
    • Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin- dependent diabetic individuals
    • DOI 10.1016/0026-0495(87)90156-9
    • Golay, A., A. L. Swislocki, Y. D. Chen, and G. M. Reaven. 1987. Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals. Metabolism. 36:692-696. (Pubitemid 17100986)
    • (1987) Metabolism: Clinical and Experimental , vol.36 , Issue.7 , pp. 692-696
    • Golay, A.1    Swislocki, A.L.M.2    Chen, Y.D.-I.3    Reaven, G.M.4
  • 58
    • 0141755328 scopus 로고    scopus 로고
    • A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
    • DOI 10.2337/diabetes.52.10.2461
    • Kashyap, S., R. Belfort, A. Gastaldelli, T. Pratipanawatr, R. Berria, W. Pratipanawatr, M. Bajaj, L. Mandarino, R. DeFronzo, and K. Cusi. 2003. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes. 52:2461-2474. (Pubitemid 37210533)
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2461-2474
    • Kashyap, S.1    Belfort, R.2    Gastaldelli, A.3    Pratipanawatr, T.4    Berria, R.5    Pratipanawatr, W.6    Bajaj, M.7    Mandarino, L.8    DeFronzo, R.9    Cusi, K.10
  • 59
    • 4344712936 scopus 로고    scopus 로고
    • In vivo regulation of plasma free fatty acids in insulin resistance
    • DOI 10.1016/j.metabol.2004.02.023, PII S0026049504001568
    • Mook, S., C. C. Halkes, S. Bilecen, and M. C. Cabezas. 2004. In vivo regulation of plasma free fatty acids in insulin resistance. Metabolism. 53:1197-1201. (Pubitemid 39140757)
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.9 , pp. 1197-1201
    • Mook, S.1    Halkes, C.J.M.2    Bilecen, S.3    Cabezas, M.C.4
  • 61
    • 33644687456 scopus 로고    scopus 로고
    • Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes
    • DOI 10.1097/01.fjc.0000187176.13403.05, PII 0000534420051200000009
    • Martens, F. M., F. L. Visseren, E. J. de Koning, and T. J. Rabelink. 2005. Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes. J. Cardiovasc. Pharmacol. 46:773-778. (Pubitemid 44378249)
    • (2005) Journal of Cardiovascular Pharmacology , vol.46 , Issue.6 , pp. 773-778
    • Martens, F.M.A.C.1    Visseren, F.L.J.2    De Koning, E.J.P.3    Rabelink, T.J.4
  • 62
    • 0035671770 scopus 로고    scopus 로고
    • Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients
    • DOI 10.1007/s001250100031
    • Miyazaki, Y., L. Glass, C. Triplitt, M. Matsuda, K. Cusi, A. Mahankali, S. Mahankali, L. J. Mandarino, and R. A. DeFronzo. 2001. Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients. Diabetologia. 44:2210-2219. (Pubitemid 34015474)
    • (2001) Diabetologia , vol.44 , Issue.12 , pp. 2210-2219
    • Miyazaki, Y.1    Glass, L.2    Triplitt, C.3    Matsuda, M.4    Cusi, K.5    Mahankali, A.6    Mahankali, S.7    Mandarino, L.J.8    DeFronzo, R.A.9
  • 63
    • 59649088286 scopus 로고    scopus 로고
    • Relationship between changes in insulin sensitivity and associated cardiovascular disease risk factors in thiazolidinedione-treated, insulin-resistant, nondiabetic individuals: Pioglitazone versus rosiglitazone
    • Abbasi, F., N. K. Lima, and G. M. Reaven. 2009. Relationship between changes in insulin sensitivity and associated cardiovascular disease risk factors in thiazolidinedione-treated, insulin-resistant, nondiabetic individuals: pioglitazone versus rosiglitazone. Metabolism. 58:373-378.
    • (2009) Metabolism , vol.58 , pp. 373-378
    • Abbasi, F.1    Lima, N.K.2    Reaven, G.M.3
  • 66
    • 22644432754 scopus 로고    scopus 로고
    • Comparison of metabolic effects of pioglitazone, metformin, and glimepiride over 1 year in Japanese patients with newly diagnosed Type 2 diabetes
    • DOI 10.1111/j.1464-5491.2005.01656.x
    • Yamanouchi, T., T. Sakai, K. Igarashi, K. Ichiyanagi, H. Watanabe, and T. Kawasaki. 2005. Comparison of metabolic effects of pioglitazone, metformin, and glimepiride over 1 year in Japanese patients with newly diagnosed Type 2 diabetes. Diabet. Med. 22:980-985. (Pubitemid 41025992)
    • (2005) Diabetic Medicine , vol.22 , Issue.8 , pp. 980-985
    • Yamanouchi, T.1    Sakai, T.2    Igarashi, K.3    Ichiyanagi, K.4    Watanabe, H.5    Kawasaki, T.6
  • 67
    • 33746082061 scopus 로고    scopus 로고
    • The effect of pioglitazone on glycemic and lipid parameters and adverse events in elderly patients with type 2 diabetes mellitus: A post hoc analysis of four randomized trials
    • DOI 10.1016/j.amjopharm.2006.06.003, PII S1543594606000250
    • Rajagopalan, R., Y. Xu, and M. Abbadessa. 2006. The effect of pioglitazone on glycemic and lipid parameters and adverse events in elderly patients with type 2 diabetes mellitus: a post hoc analysis of four randomized trials. Am. J. Geriatr. Pharmacother. 4:123-133. (Pubitemid 44069474)
    • (2006) American Journal Geriatric Pharmacotherapy , vol.4 , Issue.2 , pp. 123-133
    • Rajagopalan, R.1    Xu, Y.2    Abbadessa, M.3
  • 68
    • 51749112486 scopus 로고    scopus 로고
    • Comparison of three treatment approaches to decreasing cardiovascular disease risk in nondiabetic insulin-resistant dyslipidemic subjects
    • Abbasi, F., Y. D. Chen, H. M. Farin, C. Lamendola, and G. M. Reaven. 2008. Comparison of three treatment approaches to decreasing cardiovascular disease risk in nondiabetic insulin-resistant dyslipidemic subjects. Am. J. Cardiol. 102:64-69.
    • (2008) Am. J. Cardiol. , vol.102 , pp. 64-69
    • Abbasi, F.1    Chen, Y.D.2    Farin, H.M.3    Lamendola, C.4    Reaven, G.M.5
  • 69
    • 0035431019 scopus 로고    scopus 로고
    • The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia: The DALI study: A doubleblind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia
    • Diabetes Atorvastin Lipid Intervention (DALI) Study Group
    • Diabetes Atorvastin Lipid Intervention (DALI) Study Group. 2001. The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia: the DALI study: a doubleblind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia. Diabetes Care. 24:1335-1341.
    • (2001) Diabetes Care , vol.24 , pp. 1335-1341
  • 71
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • DOI 10.1038/90992
    • Berg, A. H., T. P. Combs, X. Du, M. Brownlee, and P. E. Scherer. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7:947-953. (Pubitemid 32756433)
    • (2001) Nature Medicine , vol.7 , Issue.8 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 72
    • 0842291596 scopus 로고    scopus 로고
    • Adiponectin Ameliorates Dyslipidemia Induced by the Human Immunodeficiency Virus Protease Inhibitor Ritonavir in Mice
    • DOI 10.1210/en.2003-1140
    • Xu, A., S. Yin, L. Wong, K. W. Chan, and K. S. Lam. 2004. Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology. 145:487-494. (Pubitemid 38183790)
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 487-494
    • Xu, A.1    Yin, S.2    Wong, L.3    Chan, K.W.4    Lam, K.S.L.5
  • 73
    • 55449125262 scopus 로고    scopus 로고
    • Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients
    • Miyazaki, Y., and R. A. DeFronzo. 2008. Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients. Diabetes Obes. Metab. 10:1204-1211.
    • (2008) Diabetes Obes. Metab. , vol.10 , pp. 1204-1211
    • Miyazaki, Y.1    DeFronzo, R.A.2
  • 75
    • 40949146982 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor-gamma activation with pioglitazone on plasma adipokines in nondiabetic patients with either hypercholesterolemia or hypertension
    • Barac, A., U. Campia, L. A. Matuskey, L. Lu, and J. A. Panza. 2008. Effects of peroxisome proliferator-activated receptor-gamma activation with pioglitazone on plasma adipokines in nondiabetic patients with either hypercholesterolemia or hypertension. Am. J. Cardiol. 101:980-985.
    • (2008) Am. J. Cardiol. , vol.101 , pp. 980-985
    • Barac, A.1    Campia, U.2    Matuskey, L.A.3    Lu, L.4    Panza, J.A.5
  • 76
    • 20444495375 scopus 로고    scopus 로고
    • Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: Results from the pioneer study
    • DOI 10.1016/j.jacc.2005.03.041, PII S0735109705007564
    • Pfützner, A., N. Marx, G. Lubben, M. Langenfeld, D. Walcher, T. Konrad, and T. Forst. 2005. Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: results from the pioneer study. J. Am. Coll. Cardiol. 45:1925-1931. (Pubitemid 40814110)
    • (2005) Journal of the American College of Cardiology , vol.45 , Issue.12 , pp. 1925-1931
    • Pfutzner, A.1    Marx, N.2    Lubben, G.3    Langenfeld, M.4    Walcher, D.5    Konrad, T.6    Forst, T.7
  • 77
    • 33947304608 scopus 로고    scopus 로고
    • Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk - The PIOSTAT Study
    • DOI 10.1016/j.metabol.2006.11.007, PII S002604950600432X
    • Forst, T., A. Pfützner, G. Lubben, M. Weber, N. Marx, E. Karagiannis, C. Koehler, W. Baurecht, C. Hohberg, and M. Hanefeld. 2007. Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk-the PIOSTAT Study. Metabolism. 56:491-496. (Pubitemid 46437254)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.4 , pp. 491-496
    • Forst, T.1    Pfutzner, A.2    Lubben, G.3    Weber, M.4    Marx, N.5    Karagiannis, E.6    Koehler, C.7    Baurecht, W.8    Hohberg, C.9    Hanefeld, M.10
  • 78
    • 33847041377 scopus 로고    scopus 로고
    • Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes
    • Eguchi, K., H. Tomizawa, J. Ishikawa, S. Hoshide, T. Numao, T. Fukuda, K. Shimada, and K. Kario. 2007. Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes. Hypertens. Res. 30:23-30.
    • (2007) Hypertens. Res. , vol.30 , pp. 23-30
    • Eguchi, K.1    Tomizawa, H.2    Ishikawa, J.3    Hoshide, S.4    Numao, T.5    Fukuda, T.6    Shimada, K.7    Kario, K.8
  • 79
    • 55549100567 scopus 로고    scopus 로고
    • Differences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes: What to add-insulin glargine or pioglitazone?
    • Dorkhan, M., A. Frid, and L. Groop. 2008. Differences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes: what to add-insulin glargine or pioglitazone? Diabetes Res. Clin. Pract. 82:340-345.
    • (2008) Diabetes Res. Clin. Pract. , vol.82 , pp. 340-345
    • Dorkhan, M.1    Frid, A.2    Groop, L.3
  • 80
    • 77957919796 scopus 로고    scopus 로고
    • PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice
    • Foryst-Ludwig, A., M. Hartge, M. Clemenz, C. Sprang, K. Hess, N. Marx, T. Unger, and U. Kintscher. 2010. PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice. Cardiovasc. Diabetol. 9:64.
    • (2010) Cardiovasc. Diabetol. , vol.9 , pp. 64
    • Foryst-Ludwig, A.1    Hartge, M.2    Clemenz, M.3    Sprang, C.4    Hess, K.5    Marx, N.6    Unger, T.7    Kintscher, U.8
  • 81
    • 39549118715 scopus 로고    scopus 로고
    • Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice
    • DOI 10.1161/CIRCULATIONAHA.107.717595
    • Ohman, M. K., Y. Shen, C. I. Obimba, A. P. Wright, M. Warnock, D. A. Lawrence, and D. T. Eitzman. 2008. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 117:798-805. (Pubitemid 351640681)
    • (2008) Circulation , vol.117 , Issue.6 , pp. 798-805
    • Ohman, M.K.1    Shen, Y.2    Obimba, C.I.3    Wright, A.P.4    Warnock, M.5    Lawrence, D.A.6    Eitzman, D.T.7
  • 83
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • DOI 10.1038/34178
    • Ricote, M., A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass. 1998. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 391:79-82. (Pubitemid 28079218)
    • (1998) Nature , vol.391 , Issue.6662 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 85
    • 49849086021 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice
    • Orasanu, G., O. Ziouzenkova, P. R. Devchand, V. Nehra, O. Hamdy, E. S. Horton, and J. Plutzky. 2008. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice. J. Am. Coll. Cardiol. 52:869-881.
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 869-881
    • Orasanu, G.1    Ziouzenkova, O.2    Devchand, P.R.3    Nehra, V.4    Hamdy, O.5    Horton, E.S.6    Plutzky, J.7
  • 86
    • 36048957806 scopus 로고    scopus 로고
    • Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells: Involvement of PPAR-alpha
    • DOI 10.1161/ATVBAHA.107.150193, PII 0004360520071100000023
    • Qin, S., T. Liu, V. S. Kamanna, and M. L. Kashyap. 2007. Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells: involvement of PPAR-alpha. Arterioscler. Thromb. Vasc. Biol. 27:2428-2434. (Pubitemid 350203960)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.11 , pp. 2428-2434
    • Qin, S.1    Liu, T.2    Kamanna, V.S.3    Kashyap, M.L.4
  • 89
    • 42449088235 scopus 로고    scopus 로고
    • Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitus
    • DOI 10.1161/CIRCULATIONAHA.107.746610
    • Davidson, M., P. M. Meyer, S. Haffner, S. Feinstein, R. D'Agostino, Sr., G. T. Kondos, A. Perez, Z. Chen, and T. Mazzone. 2008. Increased high-density lipoprotein cholesterol predicts the pioglitazone- mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitus. Circulation. 117:2123-2130. (Pubitemid 351572171)
    • (2008) Circulation , vol.117 , Issue.16 , pp. 2123-2130
    • Davidson, M.1    Meyer, P.M.2    Haffner, S.3    Feinstein, S.4    D'Agostino Sr., R.5    Kondos, G.T.6    Perez, A.7    Chen, Z.8    Mazzone, T.9
  • 90
    • 78650904244 scopus 로고    scopus 로고
    • Lowering the triglyceride/high-density lipoprotein cholesterol ratio is associated with the beneficial impact of pioglitazone on progression of coronary atherosclerosis in diabetic patients: Insights from the PERISCOPE (Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation) study
    • Nicholls, S. J., E. M. Tuzcu, K. Wolski, O. Bayturan, A. Lavoie, K. Uno, S. Kupfer, A. Perez, R. Nesto, and S. E. Nissen. 2011. Lowering the triglyceride/high-density lipoprotein cholesterol ratio is associated with the beneficial impact of pioglitazone on progression of coronary atherosclerosis in diabetic patients: insights from the PERISCOPE (Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation) study. J. Am. Coll. Cardiol. 57:153-159.
    • (2011) J. Am. Coll. Cardiol. , vol.57 , pp. 153-159
    • Nicholls, S.J.1    Tuzcu, E.M.2    Wolski, K.3    Bayturan, O.4    Lavoie, A.5    Uno, K.6    Kupfer, S.7    Perez, A.8    Nesto, R.9    Nissen, S.E.10
  • 91
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Järvinen, H. 2004. Thiazolidinediones. N. Engl. J. Med. 351: 1106-1118.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1106-1118
    • Yki-Järvinen, H.1
  • 94
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial
    • Home, P. D., S. J. Pocock, H. Beck-Nielsen, P. S. Curtis, R. Gomis, M. Hanefeld, N. P. Jones, M. Komajda, and J. J. McMurray. 2009. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet. 373:2125-2135.
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3    Curtis, P.S.4    Gomis, R.5    Hanefeld, M.6    Jones, N.P.7    Komajda, M.8    McMurray, J.J.9
  • 95
    • 44249089043 scopus 로고    scopus 로고
    • Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: A randomized controlled trial (the RECORD study)
    • Komajda, M., P. Curtis, M. Hanefeld, H. Beck-Nielsen, S. J. Pocock, A. Zambanini, N. P. Jones, R. Gomis, and P. D. Home. 2008. Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: a randomized controlled trial (the RECORD study). Cardiovasc. Diabetol. 7:10.
    • (2008) Cardiovasc. Diabetol. , vol.7 , pp. 10
    • Komajda, M.1    Curtis, P.2    Hanefeld, M.3    Beck-Nielsen, H.4    Pocock, S.J.5    Zambanini, A.6    Jones, N.P.7    Gomis, R.8    Home, P.D.9
  • 96
    • 0037422839 scopus 로고    scopus 로고
    • Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham Heart Study
    • Haider, A. W., M. G. Larson, S. S. Franklin, and D. Levy. 2003. Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham Heart Study. Ann. Intern. Med. 138:10-16. (Pubitemid 36232089)
    • (2003) Annals of Internal Medicine , vol.138 , Issue.1 , pp. 10-16
    • Haider, A.W.1    Larson, M.G.2    Franklin, S.S.3    Levy, D.4
  • 97
    • 0032587328 scopus 로고    scopus 로고
    • PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease
    • Marx, N., T. Bourcier, G. K. Sukhova, P. Libby, and J. Plutzky. 1999. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler. Thromb. Vasc. Biol. 19:546-551. (Pubitemid 29135154)
    • (1999) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.19 , Issue.3 , pp. 546-551
    • Marx, N.1    Bourcier, T.2    Sukhova, G.K.3    Libby, P.4    Plutzky, J.5
  • 98
    • 79953207315 scopus 로고    scopus 로고
    • Role of inflammation and insulin resistance in endothelial progenitor cell dysfunction
    • Desouza, C. V., F. G. Hamel, K. Bidasee, and K. O'Connell. 2011. Role of inflammation and insulin resistance in endothelial progenitor cell dysfunction. Diabetes. 60:1286-1294.
    • (2011) Diabetes , vol.60 , pp. 1286-1294
    • Desouza, C.V.1    Hamel, F.G.2    Bidasee, K.3    O'Connell, K.4
  • 99
    • 34247635096 scopus 로고    scopus 로고
    • Significance of endothelial progenitor cells in subjects with diabetes
    • DOI 10.2337/dc06-2305
    • Fadini, G. P., S. Sartore, C. Agostini, and A. Avogaro. 2007. Significance of endothelial progenitor cells in subjects with diabetes. Diabetes Care. 30:1305-1313. (Pubitemid 46684670)
    • (2007) Diabetes Care , vol.30 , Issue.5 , pp. 1305-1313
    • Fadini, G.P.1    Sartore, S.2    Agostini, C.3    Avogaro, A.4
  • 100
    • 77953781202 scopus 로고    scopus 로고
    • Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: Implications for increased cardiovascular risk
    • Jialal, I., S. Devaraj, U. Singh, and B. A. Huet. 2010. Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: implications for increased cardiovascular risk. Atherosclerosis. 211:297-302.
    • (2010) Atherosclerosis , vol.211 , pp. 297-302
    • Jialal, I.1    Devaraj, S.2    Singh, U.3    Huet, B.A.4
  • 101
    • 77955905039 scopus 로고    scopus 로고
    • Number of circulating endothelial progenitor cells as a marker of vascular endothelial function for type 2 diabetes
    • Liao, Y. F., L. L. Chen, T. S. Zeng, Y. M. Li, Y. Fan, L. J. Hu, and Y. Ling. 2010. Number of circulating endothelial progenitor cells as a marker of vascular endothelial function for type 2 diabetes. Vasc. Med. 15:279-285.
    • (2010) Vasc. Med. , vol.15 , pp. 279-285
    • Liao, Y.F.1    Chen, L.L.2    Zeng, T.S.3    Li, Y.M.4    Fan, Y.5    Hu, L.J.6    Ling, Y.7
  • 102
    • 0038028546 scopus 로고    scopus 로고
    • Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta
    • DOI 10.1161/01.ATV.0000069210.46539.0D
    • Hannan, K. M., R. J. Dilley, S. T. de Dios, and P. J. Little. 2003. Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta. Arterioscler. Thromb. Vasc. Biol. 23:762-768. (Pubitemid 36566164)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.5 , pp. 762-768
    • Hannan, K.M.1    Dilley, R.J.2    De Dios, S.T.3    Little, P.J.4
  • 104
    • 26244433267 scopus 로고    scopus 로고
    • PPARgamma-agonist rosiglitazone increases number and migratory activity of cultured endothelial progenitor cells
    • DOI 10.1016/j.atherosclerosis.2005.03.039, PII S0021915005002078
    • Pistrosch, F., K. Herbrig, U. Oelschlaegel, S. Richter, J. Passauer, S. Fischer, and P. Gross. 2005. PPARgamma-agonist rosiglitazone increases number and migratory activity of cultured endothelial progenitor cells. Atherosclerosis. 183:163-167. (Pubitemid 41416835)
    • (2005) Atherosclerosis , vol.183 , Issue.1 , pp. 163-167
    • Pistrosch, F.1    Herbrig, K.2    Oelschlaegel, U.3    Richter, S.4    Passauer, J.5    Fischer, S.6    Gross, P.7
  • 105
    • 34447309095 scopus 로고    scopus 로고
    • Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: Restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    • DOI 10.1161/CIRCULATIONAHA.106.684381
    • Sorrentino, S. A., F. H. Bahlmann, C. Besler, M. Muller, S. Schulz, N. Kirchhoff, C. Doerries, T. Horvath, A. Limbourg, F. Limbourg, et al. 2007. Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation. 116:163-173. (Pubitemid 47057522)
    • (2007) Circulation , vol.116 , Issue.2 , pp. 163-173
    • Sorrentino, S.A.1    Bahlmann, F.H.2    Besler, C.3    Muller, M.4    Schulz, S.5    Kirchhoff, N.6    Doerries, C.7    Horvath, T.8    Limbourg, A.9    Limbourg, F.10    Fliser, D.11    Haller, H.12    Drexler, H.13    Landmesser, U.14
  • 106
    • 34948859481 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance
    • DOI 10.2337/db07-0069
    • Werner, C., C. H. Kamani, C. Gensch, M. Bohm, and U. Laufs. 2007. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance. Diabetes. 56:2609-2615. (Pubitemid 47523269)
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2609-2615
    • Werner, C.1    Kamani, C.H.2    Gensch, C.3    Bohm, M.4    Laufs, U.5
  • 107
    • 45549088112 scopus 로고    scopus 로고
    • Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase
    • Boyle, J. G., P. J. Logan, M. A. Ewart, J. A. Reihill, S. A. Ritchie, J. M. Connell, S. J. Cleland, and I. P. Salt. 2008. Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase. J. Biol. Chem. 283:11210-11217.
    • (2008) J. Biol. Chem. , vol.283 , pp. 11210-11217
    • Boyle, J.G.1    Logan, P.J.2    Ewart, M.A.3    Reihill, J.A.4    Ritchie, S.A.5    Connell, J.M.6    Cleland, S.J.7    Salt, I.P.8
  • 110
    • 38149060084 scopus 로고    scopus 로고
    • Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms
    • Fernandez, M., C. Triplitt, E. Wajcberg, A. A. Sriwijilkamol, N. Musi, K. Cusi, R. DeFronzo, and E. Cersosimo. 2008. Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms. Diabetes Care. 31:121-127.
    • (2008) Diabetes Care , vol.31 , pp. 121-127
    • Fernandez, M.1    Triplitt, C.2    Wajcberg, E.3    Sriwijilkamol, A.A.4    Musi, N.5    Cusi, K.6    DeFronzo, R.7    Cersosimo, E.8
  • 111
    • 58149125347 scopus 로고    scopus 로고
    • Pioglitazone increases adiponectin levels in non-diabetic patients with coronary artery disease
    • Patel, S. R., L. M. Mailloux, J. T. Coppola, C. Mindrescu, and C. S. Staniloae. 2008. Pioglitazone increases adiponectin levels in non-diabetic patients with coronary artery disease. Coron. Artery Dis. 19: 349-353.
    • (2008) Coron. Artery Dis. , vol.19 , pp. 349-353
    • Patel, S.R.1    Mailloux, L.M.2    Coppola, J.T.3    Mindrescu, C.4    Staniloae, C.S.5
  • 112
    • 69249215302 scopus 로고    scopus 로고
    • Pioglitazone improves endothelial function with increased adiponectin and high-density lipoprotein cholesterol levels in type 2 diabetes
    • Tsuchiya, K., I. Akaza, T. Yoshimoto, and Y. Hirata. 2009. Pioglitazone improves endothelial function with increased adiponectin and high-density lipoprotein cholesterol levels in type 2 diabetes. Endocr. J. 56:691-698.
    • (2009) Endocr. J. , vol.56 , pp. 691-698
    • Tsuchiya, K.1    Akaza, I.2    Yoshimoto, T.3    Hirata, Y.4
  • 113
    • 52449132386 scopus 로고    scopus 로고
    • Impact of pioglitazone on coronary endothelial function in non-diabetic patients with coronary artery disease
    • Wöhrle, J., N. Marx, W. Koenig, V. Hombach, H. A. Kestler, M. Hoher, and T. Nusser. 2008. Impact of pioglitazone on coronary endothelial function in non-diabetic patients with coronary artery disease. Clin. Res. Cardiol. 97:726-733.
    • (2008) Clin. Res. Cardiol. , vol.97 , pp. 726-733
    • Wöhrle, J.1    Marx, N.2    Koenig, W.3    Hombach, V.4    Kestler, H.A.5    Hoher, M.6    Nusser, T.7
  • 114
    • 79959735464 scopus 로고    scopus 로고
    • Effect of pioglitazone on endothelial dysfunction after sirolimus- Eluting stent implantation
    • Kitahara, H., Y. Kobayashi, Y. Iwata, Y. Fujimoto, and I. Komuro. 2011. Effect of pioglitazone on endothelial dysfunction after sirolimus- eluting stent implantation. Am. J. Cardiol. 108:214-219.
    • (2011) Am. J. Cardiol. , vol.108 , pp. 214-219
    • Kitahara, H.1    Kobayashi, Y.2    Iwata, Y.3    Fujimoto, Y.4    Komuro, I.5
  • 115
    • 38549125571 scopus 로고    scopus 로고
    • Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: Thiazolidinediones (glitazones) have enhanced activity under high glucose conditions
    • Little, P. J., N. Osman, S. T. de Dios, N. Cemerlang, M. Ballinger, and J. Nigro. 2007. Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions. Cardiovasc. Diabetol. 6:33.
    • (2007) Cardiovasc. Diabetol. , vol.6 , pp. 33
    • Little, P.J.1    Osman, N.2    De Dios, S.T.3    Cemerlang, N.4    Ballinger, M.5    Nigro, J.6
  • 117
    • 78650416365 scopus 로고    scopus 로고
    • Cellular and molecular changes associated with inhibitory effect of pioglitazone on neointimal growth in patients with type 2 diabetes after zotarolimus- Eluting stent implantation
    • Hong, S. J., S. T. Kim, T. J. Kim, E. O. Kim, C. M. Ahn, J. H. Park, J. S. Kim, K. M. Lee, and D. S. Lim. 2010. Cellular and molecular changes associated with inhibitory effect of pioglitazone on neointimal growth in patients with type 2 diabetes after zotarolimus- eluting stent implantation. Arterioscler. Thromb. Vasc. Biol. 30: 2655-2665.
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 2655-2665
    • Hong, S.J.1    Kim, S.T.2    Kim, T.J.3    Kim, E.O.4    Ahn, C.M.5    Park, J.H.6    Kim, J.S.7    Lee, K.M.8    Lim, D.S.9
  • 118
    • 0037674923 scopus 로고    scopus 로고
    • Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation
    • DOI 10.1161/01.CIR.0000074040.31731.96
    • de Dios, S. T., D. Bruemmer, R. J. Dilley, M. E. Ivey, G. L. Jennings, R. E. Law, and P. J. Little. 2003. Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation. Circulation. 107: 2548-2550. (Pubitemid 36628933)
    • (2003) Circulation , vol.107 , Issue.20 , pp. 2548-2550
    • De Dios, S.T.1    Bruemmer, D.2    Dilley, R.J.3    Ivey, M.E.4    Jennings, G.L.R.5    Law, R.E.6    Little, P.J.7
  • 119
    • 58549087924 scopus 로고    scopus 로고
    • Effect of thiazolidinediones on in-stent restenosis in patients after coronary stenting: A meta-analysis of randomized controlled trials
    • Geng, D. F., D. M. Jin, W. Wu, Z. Wang, and J. F. Wang. 2009. Effect of thiazolidinediones on in-stent restenosis in patients after coronary stenting: a meta-analysis of randomized controlled trials. Atherosclerosis. 202:521-528.
    • (2009) Atherosclerosis , vol.202 , pp. 521-528
    • Geng, D.F.1    Jin, D.M.2    Wu, W.3    Wang, Z.4    Wang, J.F.5
  • 120
    • 79953000587 scopus 로고    scopus 로고
    • Role of pioglitazone in the prevention of restenosis and need for revascularization after bare-metal stent implantation: A meta-analysis
    • Patel, D., B. Walitt, J. Lindsay, and R. L. Wilensky. 2011. Role of pioglitazone in the prevention of restenosis and need for revascularization after bare-metal stent implantation: a meta-analysis. JACC Cardiovasc. Interv. 4:353-360.
    • (2011) JACC Cardiovasc. Interv. , vol.4 , pp. 353-360
    • Patel, D.1    Walitt, B.2    Lindsay, J.3    Wilensky, R.L.4
  • 121
    • 33846657175 scopus 로고    scopus 로고
    • Thiazolidinediones and risk of repeat target vessel revascularization following percutaneous coronary intervention: A meta-analysis
    • DOI 10.2337/dc06-1854
    • Riche, D. M., R. Valderrama, and N. N. Henyan. 2007. Thiazolidinediones and risk of repeat target vessel revascularization following percutaneous coronary intervention: a meta-analysis. Diabetes Care. 30:384-388. (Pubitemid 46198353)
    • (2007) Diabetes Care , vol.30 , Issue.2 , pp. 384-388
    • Riche, D.M.1    Valderrama, R.2    Henyan, N.N.3
  • 122
    • 37449022956 scopus 로고    scopus 로고
    • Thiazolidinediones may be effective in the prevention of stent thrombosis with DES
    • Cao, Z., and Y. Zhou. 2008. Thiazolidinediones may be effective in the prevention of stent thrombosis with DES. Med. Hypotheses. 70: 329-332.
    • (2008) Med. Hypotheses , vol.70 , pp. 329-332
    • Cao, Z.1    Zhou, Y.2
  • 125
    • 80054091294 scopus 로고    scopus 로고
    • Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging
    • Vucic, E., S. D. Dickson, C. Calcagno, J. H. Rudd, E. Moshier, K. Hayashi, J. S. Mounessa, M. Roytman, M. J. Moon, J. Lin, et al. 2011. Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging. JACC Cardiovasc. Imaging. 4:1100-1109.
    • (2011) JACC Cardiovasc. Imaging , vol.4 , pp. 1100-1109
    • Vucic, E.1    Dickson, S.D.2    Calcagno, C.3    Rudd, J.H.4    Moshier, E.5    Hayashi, K.6    Mounessa, J.S.7    Roytman, M.8    Moon, M.J.9    Lin, J.10
  • 126
    • 28644435157 scopus 로고    scopus 로고
    • mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease
    • DOI 10.1136/jcp.2005.026161
    • Soumian, S., R. Gibbs, A. Davies, and C. Albrecht. 2005. mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease. J. Clin. Pathol. 58:1255-1260. (Pubitemid 41752768)
    • (2005) Journal of Clinical Pathology , vol.58 , Issue.12 , pp. 1255-1260
    • Soumian, S.1    Gibbs, R.2    Davies, A.3    Albrecht, C.4
  • 127
    • 77954030199 scopus 로고    scopus 로고
    • Increased expression of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma in human atherosclerosis
    • Sueyoshi, S., M. Mitsumata, Y. Kusumi, M. Niihashi, M. Esumi, T. Yamada, and I. Sakurai. 2010. Increased expression of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma in human atherosclerosis. Pathol. Res. Pract. 206:429-438.
    • (2010) Pathol. Res. Pract. , vol.206 , pp. 429-438
    • Sueyoshi, S.1    Mitsumata, M.2    Kusumi, Y.3    Niihashi, M.4    Esumi, M.5    Yamada, T.6    Sakurai, I.7
  • 129
    • 65649099695 scopus 로고    scopus 로고
    • Effect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone)
    • Lonn, E. M., H. C. Gerstein, P. Sheridan, S. Smith, R. Diaz, V. Mohan, J. Bosch, S. Yusuf, and G. R. Dagenais. 2009. Effect of ramipril and of rosiglitazone on carotid intima-media thickness in people with impaired glucose tolerance or impaired fasting glucose: STARR (STudy of Atherosclerosis with Ramipril and Rosiglitazone). J. Am. Coll. Cardiol. 53:2028-2035.
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 2028-2035
    • Lonn, E.M.1    Gerstein, H.C.2    Sheridan, P.3    Smith, S.4    Diaz, R.5    Mohan, V.6    Bosch, J.7    Yusuf, S.8    Dagenais, G.R.9
  • 131
    • 77955984948 scopus 로고    scopus 로고
    • Pioglitazone versus glimepiride on coronary artery calcium progression in patients with type 2 diabetes mellitus: A secondary end point of the CHICAGO study
    • Davidson, M. H., C. A. Beam, S. Haffner, A. Perez, R. D'Agostino, Sr., and T. Mazzone. 2010. Pioglitazone versus glimepiride on coronary artery calcium progression in patients with type 2 diabetes mellitus: a secondary end point of the CHICAGO study. Arterioscler. Thromb. Vasc. Biol. 30:1873-1876.
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1873-1876
    • Davidson, M.H.1    Beam, C.A.2    Haffner, S.3    Perez, A.4    D'Agostino Sr., R.5    Mazzone, T.6
  • 132
    • 73349109150 scopus 로고    scopus 로고
    • Searching for the right outcome? A systematic review and meta-analysis of controlled trials using carotid intima-media thickness or pulse wave velocity to infer antiatherogenic properties of thiazolidinediones
    • Webb, D. R., M. J. Davies, L. J. Gray, K. R. Abrams, B. Srinivasan, S. Das, N. Taub, I. Lawrence, S. Sutton, and K. Khunti. 2010. Searching for the right outcome? A systematic review and meta-analysis of controlled trials using carotid intima-media thickness or pulse wave velocity to infer antiatherogenic properties of thiazolidinediones. Diabetes Obes. Metab. 12:124-132.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 124-132
    • Webb, D.R.1    Davies, M.J.2    Gray, L.J.3    Abrams, K.R.4    Srinivasan, B.5    Das, S.6    Taub, N.7    Lawrence, I.8    Sutton, S.9    Khunti, K.10
  • 134
    • 79551714212 scopus 로고    scopus 로고
    • The effects of pioglitazone in reducing atherosclerosis progression and neointima volume in type 2 diabetic patients: Prospective randomized study with volumetric intravascular ultrasonography analysis
    • You, S. H., B. S. Kim, S. J. Hong, C. M. Ahn, and D. S. Lim. 2010. The effects of pioglitazone in reducing atherosclerosis progression and neointima volume in type 2 diabetic patients: prospective randomized study with volumetric intravascular ultrasonography analysis. Korean Circ. J. 40:625-631.
    • (2010) Korean Circ. J. , vol.40 , pp. 625-631
    • You, S.H.1    Kim, B.S.2    Hong, S.J.3    Ahn, C.M.4    Lim, D.S.5
  • 135
    • 84863119468 scopus 로고    scopus 로고
    • Pioglitazone induces regression and stabilization of coronary atherosclerotic plaques in patients with impaired glucose tolerance
    • Yang, H. B., X. Y. Zhao, J. Y. Zhang, Y. Y. Du, and X. F. Wang. 2012. Pioglitazone induces regression and stabilization of coronary atherosclerotic plaques in patients with impaired glucose tolerance. Diabet. Med. 29: 359-365.
    • (2012) Diabet. Med. , vol.29 , pp. 359-365
    • Yang, H.B.1    Zhao, X.Y.2    Zhang, J.Y.3    Du, Y.Y.4    Wang, X.F.5
  • 136
    • 59449098955 scopus 로고    scopus 로고
    • Pioglitazone reduces the necrotic-core component in coronary plaque in association with enhanced plasma adiponectin in patients with type 2 diabetes mellitus
    • Ogasawara, D., J. Shite, T. Shinke, S. Watanabe, H. Otake, Y. Tanino, T. Sawada, H. Kawamori, H. Kato, N. Miyoshi, et al. 2009. Pioglitazone reduces the necrotic-core component in coronary plaque in association with enhanced plasma adiponectin in patients with type 2 diabetes mellitus. Circ. J. 73:343-351.
    • (2009) Circ. J. , vol.73 , pp. 343-351
    • Ogasawara, D.1    Shite, J.2    Shinke, T.3    Watanabe, S.4    Otake, H.5    Tanino, Y.6    Sawada, T.7    Kawamori, H.8    Kato, H.9    Miyoshi, N.10
  • 137
    • 73749087583 scopus 로고    scopus 로고
    • Pioglitazone induces regression of coronary atherosclerotic plaques in patients with type 2 diabetes mellitus or impaired glucose tolerance: A randomized prospective study using intravascular ultrasound
    • Nakayama, T., N. Komiyama, M. Yokoyama, S. Namikawa, N. Kuroda, Y. Kobayashi, and I. Komuro. 2010. Pioglitazone induces regression of coronary atherosclerotic plaques in patients with type 2 diabetes mellitus or impaired glucose tolerance: a randomized prospective study using intravascular ultrasound. Int. J. Cardiol. 138:157-165.
    • (2010) Int. J. Cardiol. , vol.138 , pp. 157-165
    • Nakayama, T.1    Komiyama, N.2    Yokoyama, M.3    Namikawa, S.4    Kuroda, N.5    Kobayashi, Y.6    Komuro, I.7
  • 138
    • 77955272826 scopus 로고    scopus 로고
    • Cardiometabolic effects of rosiglitazone in patients with type 2 diabetes and coronary artery bypass grafts: A randomized placebo-controlled clinical trial
    • Bertrand, O. F., P. Poirier, J. Rodes-Cabau, S. Rinfret, L. M. Title, V. Dzavik, M. Natarajan, J. Angel, N. Batalla, N. Almeras, et al. 2010. Cardiometabolic effects of rosiglitazone in patients with type 2 diabetes and coronary artery bypass grafts: a randomized placebo-controlled clinical trial. Atherosclerosis. 211:565-573.
    • (2010) Atherosclerosis , vol.211 , pp. 565-573
    • Bertrand, O.F.1    Poirier, P.2    Rodes-Cabau, J.3    Rinfret, S.4    Title, L.M.5    Dzavik, V.6    Natarajan, M.7    Angel, J.8    Batalla, N.9    Almeras, N.10
  • 139
    • 77950474638 scopus 로고    scopus 로고
    • Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: The assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history trial
    • Gerstein, H. C., R. E. Ratner, C. P. Cannon, P. W. Serruys, H. M. Garcia-Garcia, G. A. van Es, N. S. Kolatkar, B. G. Kravitz, D. M. Miller, C. Huang, et al. 2010. Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history trial. Circulation. 121:1176-1187.
    • (2010) Circulation , vol.121 , pp. 1176-1187
    • Gerstein, H.C.1    Ratner, R.E.2    Cannon, C.P.3    Serruys, P.W.4    Garcia-Garcia, H.M.5    Van Es, G.A.6    Kolatkar, N.S.7    Kravitz, B.G.8    Miller, D.M.9    Huang, C.10
  • 140
    • 12744268367 scopus 로고    scopus 로고
    • Rosiglitazone treatment in Zucker diabetic Fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion- induced myocardial injury
    • Yue, T. L., W. Bao, J. L. Gu, J. Cui, L. Tao, X. L. Ma, E. H. Ohlstein, and B. M. Jucker. 2005. Rosiglitazone treatment in Zucker diabetic Fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury. Diabetes. 54:554-562.
    • (2005) Diabetes , vol.54 , pp. 554-562
    • Yue, T.L.1    Bao, W.2    Gu, J.L.3    Cui, J.4    Tao, L.5    Ma, X.L.6    Ohlstein, E.H.7    Jucker, B.M.8
  • 143
    • 33644689410 scopus 로고    scopus 로고
    • Pioglitazone mimics preconditioning in the isolated perfused rat heart: A role for the prosurvival kinases PI3K and P42/44MAPK
    • DOI 10.1097/01.fjc.0000188365.07635.57, PII 0000534420051200000015
    • Wynne, A. M., M. M. Mocanu, and D. M. Yellon. 2005. Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPK. J. Cardiovasc. Pharmacol. 46:817-822. (Pubitemid 44378255)
    • (2005) Journal of Cardiovascular Pharmacology , vol.46 , Issue.6 , pp. 817-822
    • Wynne, A.M.1    Mocanu, M.M.2    Yellon, D.M.3
  • 144
    • 0036224012 scopus 로고    scopus 로고
    • Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the Zucker fatty rat heart
    • Sidell, R. J., M. A. Cole, N. J. Draper, M. Desrois, R. E. Buckingham, and K. Clarke. 2002. Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker Fatty rat heart. Diabetes. 51:1110-1117. (Pubitemid 34438357)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1110-1117
    • Sidell, R.J.1    Cole, M.A.2    Draper, N.J.3    Desrois, M.4    Buckingham, R.E.5    Clarke, K.6
  • 145
    • 33746843082 scopus 로고    scopus 로고
    • Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK
    • DOI 10.1152/ajpheart.00926.2005
    • Molavi, B., J. Chen, and J. L. Mehta. 2006. Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK. Am. J. Physiol. Heart Circ. Physiol. 291:H687-H693. (Pubitemid 44175074)
    • (2006) American Journal of Physiology - Heart and Circulatory Physiology , vol.291 , Issue.2
    • Molavi, B.1    Chen, J.2    Mehta, J.L.3
  • 146
    • 79951491203 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor gamma mediates the second window of anaesthetic-induced preconditioning
    • Lotz, C., M. Lange, A. Redel, J. Stumpner, J. Schmidt, T. Tischer-Zeitz, N. Roewer, and F. Kehl. 2011. Peroxisome-proliferator-activated receptor gamma mediates the second window of anaesthetic-induced preconditioning. Exp. Physiol. 96:317-324.
    • (2011) Exp. Physiol. , vol.96 , pp. 317-324
    • Lotz, C.1    Lange, M.2    Redel, A.3    Stumpner, J.4    Schmidt, J.5    Tischer-Zeitz, T.6    Roewer, N.7    Kehl, F.8
  • 147
    • 58449125170 scopus 로고    scopus 로고
    • Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation-a novel mechanism for the cardioprotective effects of PPAR agonists
    • Liu, H. R., L. Tao, E. Gao, Y. Qu, W. B. Lau, B. L. Lopez, T. A. Christopher, W. Koch, T. L. Yue, and X. L. Ma. 2009. Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation-a novel mechanism for the cardioprotective effects of PPAR agonists. Cardiovasc. Res. 81:344-352.
    • (2009) Cardiovasc. Res. , vol.81 , pp. 344-352
    • Liu, H.R.1    Tao, L.2    Gao, E.3    Qu, Y.4    Lau, W.B.5    Lopez, B.L.6    Christopher, T.A.7    Koch, W.8    Yue, T.L.9    Ma, X.L.10
  • 148
    • 0036319490 scopus 로고    scopus 로고
    • 2-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury
    • Khandoudi, N., P. Delerive, I. Berrebi-Bertrand, R. E. Buckingham, B. Staels, and A. Bril. 2002. Rosiglitazone, a peroxisome proliferator- activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury. Diabetes. 51:1507-1514. (Pubitemid 34826618)
    • (2002) Diabetes , vol.51 , Issue.5 , pp. 1507-1514
    • Khandoudi, N.1    Delerive, P.2    Berrebi-Bertrand, I.3    Buckingham, R.E.4    Staels, B.5    Bril, A.6
  • 149
    • 34247346490 scopus 로고    scopus 로고
    • Effect of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on ischemia-reperfusion injury in rats
    • DOI 10.1159/000100870
    • Cao, Z., P. Ye, C. Long, K. Chen, X. Li, and H. Wang. 2007. Effect of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on ischemia-reperfusion injury in rats. Pharmacology. 79: 184-192. (Pubitemid 46631932)
    • (2007) Pharmacology , vol.79 , Issue.3 , pp. 184-192
    • Cao, Z.1    Ye, P.2    Long, C.3    Chen, K.4    Li, X.5    Wang, H.6
  • 150
    • 0141788713 scopus 로고    scopus 로고
    • Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin43 proteins
    • Lee, T. M., and T. F. Chou. 2003. Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin43 proteins. Am. J. Physiol. Heart Circ. Physiol. 285: H1650-H1659.
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.285
    • Lee, T.M.1    Chou, T.F.2
  • 151
    • 0034646419 scopus 로고    scopus 로고
    • Troglitazone improves recovery of left ventricular function after regional ischemia in pigs
    • Zhu, P., L. Lu, Y. Xu, and G. G. Schwartz. 2000. Troglitazone improves recovery of left ventricular function after regional ischemia in pigs. Circulation. 101:1165-1171. (Pubitemid 30146619)
    • (2000) Circulation , vol.101 , Issue.10 , pp. 1165-1171
    • Zhu, P.1    Lu, L.2    Xu, Y.3    Schwartz, G.G.4
  • 152
    • 33750485826 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator-activated receptor gamma ligand. Rosiglitazone on left ventricular remodeling in rats with myocardial infarction
    • DOI 10.1016/j.ijcard.2006.03.060, PII S0167527306004463
    • Geng, D. F., W. Wu, D. M. Jin, J. F. Wang, and Y. M. Wu. 2006. Effect of peroxisome proliferator-activated receptor gamma ligand. Rosiglitazone on left ventricular remodeling in rats with myocardial infarction. Int. J. Cardiol. 113:86-91. (Pubitemid 44648366)
    • (2006) International Journal of Cardiology , vol.113 , Issue.1 , pp. 86-91
    • Geng, D.-f.1    Wu, W.2    Jin, D.-m.3    Wang, J.-f.4    Wu, Y.-m.5
  • 153
    • 0037058874 scopus 로고    scopus 로고
    • Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction
    • DOI 10.1161/01.CIR.0000039346.31538.2C
    • Shiomi, T., H. Tsutsui, S. Hayashidani, N. Suematsu, M. Ikeuchi, J. Wen, M. Ishibashi, T. Kubota, K. Egashira, and A. Takeshita. 2002. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation. 106:3126-3132. (Pubitemid 35440299)
    • (2002) Circulation , vol.106 , Issue.24 , pp. 3126-3132
    • Shiomi, T.1    Tsutsui, H.2    Hayashidani, S.3    Suematsu, N.4    Ikeuchi, M.5    Wen, J.6    Ishibashi, M.7    Kubota, T.8    Egashira, K.9    Takeshita, A.10
  • 155
    • 0038460061 scopus 로고    scopus 로고
    • The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction
    • DOI 10.1016/S0008-6363(03)00289-X
    • Lygate, C. A., K. Hulbert, M. Monfared, M. A. Cole, K. Clarke, and S. Neubauer. 2003. The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction. Cardiovasc. Res. 58:632-637. (Pubitemid 36700421)
    • (2003) Cardiovascular Research , vol.58 , Issue.3 , pp. 632-637
    • Lygate, C.A.1    Hulbert, K.2    Monfared, M.3    Cole, M.A.4    Clarke, K.5    Neubauer, S.6
  • 158
    • 33947204503 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents
    • DOI 10.1111/j.1471-4159.2006.04376.x
    • Tureyen, K., R. Kapadia, K. K. Bowen, I. Satriotomo, J. Liang, D. L. Feinstein, and R. Vemuganti. 2007. Peroxisome proliferatoractivated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J. Neurochem. 101:41-56. (Pubitemid 46426485)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.1 , pp. 41-56
    • Tureyen, K.1    Kapadia, R.2    Bowen, K.K.3    Satriotomo, I.4    Liang, J.5    Feinstein, D.L.6    Vemuganti, R.7
  • 159
    • 62649096776 scopus 로고    scopus 로고
    • Ligand-activated peroxisome proliferator-activated receptorgamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation
    • Wu, J. S., W. M. Cheung, Y. S. Tsai, Y. T. Chen, W. H. Fong, H. D. Tsai, Y. C. Chen, J. Y. Liou, S. K. Shyue, J. J. Chen, et al. 2009. Ligand-activated peroxisome proliferator-activated receptorgamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. Circulation. 119: 1124-1134.
    • (2009) Circulation , vol.119 , pp. 1124-1134
    • Wu, J.S.1    Cheung, W.M.2    Tsai, Y.S.3    Chen, Y.T.4    Fong, W.H.5    Tsai, H.D.6    Chen, Y.C.7    Liou, J.Y.8    Shyue, S.K.9    Chen, J.J.10
  • 160
    • 79851512032 scopus 로고    scopus 로고
    • Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-kappaB signaling pathway
    • Zhang, H. L., M. Xu, C. Wei, A. P. Qin, C. F. Liu, L. Z. Hong, X. Y. Zhao, J. Liu, and Z. H. Qin. 2011. Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-kappaB signaling pathway. Neuroscience. 176:381-395.
    • (2011) Neuroscience , vol.176 , pp. 381-395
    • Zhang, H.L.1    Xu, M.2    Wei, C.3    Qin, A.P.4    Liu, C.F.5    Hong, L.Z.6    Zhao, X.Y.7    Liu, J.8    Qin, Z.H.9
  • 161
    • 23044475502 scopus 로고    scopus 로고
    • The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain
    • DOI 10.1111/j.1460-9568.2005.04200.x
    • Zhao, Y., A. Patzer, P. Gohlke, T. Herdegen, and J. Culman. 2005. The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain. Eur. J. Neurosci. 22:278-282. (Pubitemid 41059994)
    • (2005) European Journal of Neuroscience , vol.22 , Issue.1 , pp. 278-282
    • Zhao, Y.1    Patzer, A.2    Gohlke, P.3    Herdegen, T.4    Culman, J.5
  • 162
    • 77449083692 scopus 로고    scopus 로고
    • The effects of the PPAR-gamma agonist pioglitazone on plasma concentrations of circulating vasoactive factors in type II diabetes mellitus
    • de Boer, R. A., F. M. Martens, I. Kuipers, F. Boomsma, and F. L. Visseren. 2010. The effects of the PPAR-gamma agonist pioglitazone on plasma concentrations of circulating vasoactive factors in type II diabetes mellitus. J. Hum. Hypertens. 24:74-76.
    • (2010) J. Hum. Hypertens. , vol.24 , pp. 74-76
    • De Boer, R.A.1    Martens, F.M.2    Kuipers, I.3    Boomsma, F.4    Visseren, F.L.5
  • 164
    • 0042383369 scopus 로고    scopus 로고
    • Plasma BNP levels in the treatment of type 2 diabetes with pioglitazone
    • DOI 10.1210/jc.2002-021765
    • Ogawa, S., K. Takeuchi, and S. Ito. 2003. Plasma BNP levels in the treatment of type 2 diabetes with pioglitazone. J. Clin. Endocrinol. Metab. 88:3993-3996. (Pubitemid 37034557)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.8 , pp. 3993-3996
    • Ogawa, S.1    Takeuchi, K.2    Ito, S.3
  • 165
    • 33846205131 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on inflammatory markers and adipokines: Decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type 2 diabetes mellitus
    • DOI 10.1111/j.1365-2265.2006.02723.x
    • Kim, H. J., E. S. Kang, D. J. Kim, S. H. Kim, C. W. Ahn, B. S. Cha, M. Nam, C. H. Chung, K. W. Lee, C. M. Nam, et al. 2007. Effects of rosiglitazone and metformin on inflammatory markers and adipokines: decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type 2 diabetes mellitus. Clin. Endocrinol. (Oxf.). 66:282-289. (Pubitemid 46096150)
    • (2007) Clinical Endocrinology , vol.66 , Issue.2 , pp. 282-289
    • Kim, H.J.1    Kang, E.S.2    Kim, D.J.3    Kim, S.H.4    Ahn, C.W.5    Cha, B.S.6    Nam, M.7    Chung, C.H.8    Lee, K.W.9    Nam, C.M.10    Lee, H.C.11
  • 167
    • 73349107151 scopus 로고    scopus 로고
    • Effects of intensive insulin therapy alone and with added pioglitazone on renal salt/water balance and fluid compartment shifts in type 2 diabetes
    • Mudaliar, S., A. R. Chang, V. R. Aroda, E. Chao, P. Burke, S. Baxi, K. A. Griver, D. T. O'Connor, and R. R. Henry. 2010. Effects of intensive insulin therapy alone and with added pioglitazone on renal salt/water balance and fluid compartment shifts in type 2 diabetes. Diabetes Obes. Metab. 12:133-138.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 133-138
    • Mudaliar, S.1    Chang, A.R.2    Aroda, V.R.3    Chao, E.4    Burke, P.5    Baxi, S.6    Griver, K.A.7    O'Connor, D.T.8    Henry, R.R.9
  • 169
    • 23844472901 scopus 로고    scopus 로고
    • Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption
    • DOI 10.1038/nm1278
    • Guan, Y., C. Hao, D. R. Cha, R. Rao, W. Lu, D. E. Kohan, M. A. Magnuson, R. Redha, Y. Zhang, and M. D. Breyer. 2005. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat. Med. 11: 861-866. (Pubitemid 41161118)
    • (2005) Nature Medicine , vol.11 , Issue.8 , pp. 861-866
    • Guan, Y.1    Hao, C.2    Cha, D.R.3    Rao, R.4    Lu, W.5    Kohan, D.E.6    Magnuson, M.A.7    Redha, R.8    Zhang, Y.9    Breyer, M.D.10
  • 170
    • 42049103429 scopus 로고    scopus 로고
    • Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone
    • Artunc, F., D. Sandulache, O. Nasir, K. M. Boini, B. Friedrich, N. Beier, E. Dicks, S. Potzsch, K. Klingel, K. Amann, et al. 2008. Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone. Pflugers Arch. 456:425-436.
    • (2008) Pflugers Arch. , vol.456 , pp. 425-436
    • Artunc, F.1    Sandulache, D.2    Nasir, O.3    Boini, K.M.4    Friedrich, B.5    Beier, N.6    Dicks, E.7    Potzsch, S.8    Klingel, K.9    Amann, K.10
  • 171
    • 79955624781 scopus 로고    scopus 로고
    • Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARgamma-dependent nongenomic signaling
    • Endo, Y., M. Suzuki, H. Yamada, S. Horita, M. Kunimi, O. Yamazaki, A. Shirai, M. Nakamura, O. Iso, Y. Li, et al. 2011. Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARgamma-dependent nongenomic signaling. Cell Metab. 13:550-561.
    • (2011) Cell Metab. , vol.13 , pp. 550-561
    • Endo, Y.1    Suzuki, M.2    Yamada, H.3    Horita, S.4    Kunimi, M.5    Yamazaki, O.6    Shirai, A.7    Nakamura, M.8    Iso, O.9    Li, Y.10
  • 173
    • 34247153877 scopus 로고    scopus 로고
    • A Randomized, Placebo-Controlled Trial Assessing the Effects of Rosiglitazone on Echocardiographic Function and Cardiac Status in Type 2 Diabetic Patients With New York Heart Association Functional Class I or II Heart Failure
    • DOI 10.1016/j.jacc.2006.10.077, PII S073510970700558X
    • Dargie, H. J., P. R. Hildebrandt, G. A. Riegger, J. J. McMurray, S. O. McMorn, J. N. Roberts, A. Zambanini, and J. P. Wilding. 2007. A randomized, placebo-controlled trial assessing the effects of rosiglitazone on echocardiographic function and cardiac status in type 2 diabetic patients with New York Heart Association Functional Class I or II Heart Failure. J. Am. Coll. Cardiol. 49: 1696-1704. (Pubitemid 46589926)
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.16 , pp. 1696-1704
    • Dargie, H.J.1    Hildebrandt, P.R.2    Riegger, G.A.J.3    McMurray, J.J.V.4    McMorn, S.O.5    Roberts, J.N.6    Zambanini, A.7    Wilding, J.P.H.8
  • 175
    • 56249121001 scopus 로고    scopus 로고
    • Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease
    • Von Bibra, H., M. Diamant, P. G. Scheffer, T. Siegmund, and P. M. Schumm-Draeger. 2008. Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease. Diab. Vasc. Dis. Res. 5:310-318.
    • (2008) Diab. Vasc. Dis. Res. , vol.5 , pp. 310-318
    • Von Bibra, H.1    Diamant, M.2    Scheffer, P.G.3    Siegmund, T.4    Schumm-Draeger, P.M.5
  • 176
    • 78049245845 scopus 로고    scopus 로고
    • Pioglitazone improves ventricular diastolic function in patients with diabetes mellitus: A tissue Doppler study
    • Ordu, S., H. Ozhan, R. Alemdar, M. Aydin, C. Basar, O. Caglar, M. Yazici, and S. Yalcin. 2010. Pioglitazone improves ventricular diastolic function in patients with diabetes mellitus: a tissue Doppler study. Acta Cardiol. 65:401-406.
    • (2010) Acta Cardiol. , vol.65 , pp. 401-406
    • Ordu, S.1    Ozhan, H.2    Alemdar, R.3    Aydin, M.4    Basar, C.5    Caglar, O.6    Yazici, M.7    Yalcin, S.8
  • 178
    • 67649980379 scopus 로고    scopus 로고
    • Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl) carbonyl]-2-methyl-6- (trifluoromethoxy)-1H- indol-1-yl}phenoxy) butanoic acid (MK-0533): A novel selective peroxisome proliferator- activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume
    • Acton III, J. J., T. E. Akiyama, C. H. Chang, L. Colwell, S. Debenham, T. Doebber, M. Einstein, K. Liu, M. E. McCann, D. E. Moller, et al. 2009. Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl) carbonyl]-2-methyl-6- (trifluoromethoxy)-1H- indol-1-yl}phenoxy) butanoic acid (MK-0533): a novel selective peroxisome proliferator- activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume. J. Med. Chem. 52:3846-3854.
    • (2009) J. Med. Chem. , vol.52 , pp. 3846-3854
    • Acton III, J.J.1    Akiyama, T.E.2    Chang, C.H.3    Colwell, L.4    Debenham, S.5    Doebber, T.6    Einstein, M.7    Liu, K.8    McCann, M.E.9    Moller, D.E.10
  • 179
    • 78651075521 scopus 로고    scopus 로고
    • PAM-1616, a selective peroxisome proliferator-activated receptor gamma modulator with preserved anti-diabetic efficacy and reduced adverse effects
    • Kim, M. K., Y. N. Chae, S. H. Choi, H. S. Moon, M. H. Son, M. H. Bae, H. H. Choi, Y. Hur, E. Kim, Y. H. Park, et al. 2011. PAM-1616, a selective peroxisome proliferator-activated receptor gamma modulator with preserved anti-diabetic efficacy and reduced adverse effects. Eur. J. Pharmacol. 650:673-681.
    • (2011) Eur. J. Pharmacol. , vol.650 , pp. 673-681
    • Kim, M.K.1    Chae, Y.N.2    Choi, S.H.3    Moon, H.S.4    Son, M.H.5    Bae, M.H.6    Choi, H.H.7    Hur, Y.8    Kim, E.9    Park, Y.H.10
  • 182
    • 0030610295 scopus 로고    scopus 로고
    • Effect of englitazone on K(ATP) and calcium-activated nonselective cation channels in CRI-G1 insulin-secreting cells
    • DOI 10.1038/sj.bjp.0701145
    • Rowe, I. C., K. Lee, R. N. Khan, and M. L. Ashford. 1997. Effect of englitazone on KATP and calcium-activated non-selective cation channels in CRI-G1 insulin-secreting cells. Br. J. Pharmacol. 121: 531-539. (Pubitemid 27226307)
    • (1997) British Journal of Pharmacology , vol.121 , Issue.3 , pp. 531-539
    • Rowe, I.C.M.1    Lee, K.2    Khan, R.N.3    Ashford, M.L.J.4
  • 183
    • 0034082476 scopus 로고    scopus 로고
    • Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone
    • McKay, N. G., J. M. Kinsella, C. M. Campbell, and M. L. Ashford. 2000. Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone. Br. J. Pharmacol. 130:857-866. (Pubitemid 30389066)
    • (2000) British Journal of Pharmacology , vol.130 , Issue.4 , pp. 857-866
    • McKay, N.G.1    Kinsella, J.M.2    Campbell, C.M.3    Ashford, M.L.J.4
  • 184
    • 0030578930 scopus 로고    scopus 로고
    • Inhibition of K(ATP) channel activity by troglitazone in CRI-G1 insulin-secreting cells
    • DOI 10.1016/0014-2999(96)00619-X
    • Lee, K., T. Ibbotson, P. J. Richardson, and P. R. Boden. 1996. Inhibition of KATP channel activity by troglitazone in CRI-G1 insulin-secreting cells. Eur. J. Pharmacol. 313:163-167. (Pubitemid 26342221)
    • (1996) European Journal of Pharmacology , vol.313 , Issue.1-2 , pp. 163-167
    • Lee, K.1    Ibbotson, T.2    Richardson, P.J.3    Boden, P.R.4
  • 185
    • 0030894742 scopus 로고    scopus 로고
    • Troglitazone inhibits type 2 K(ATP) channel activity and depolarises tolbutamide-sensitive neurones in the rat ventromedial hypothalamus
    • DOI 10.1016/S0006-8993(97)00046-2, PII S0006899397000462
    • Lee, K., and P. Boden. 1997. Troglitazone inhibits type 2KATP channel activity and depolarises tolbutamide-sensitive neurones in the rat ventromedial hypothalamus. Brain Res. 751:165-168. (Pubitemid 27122151)
    • (1997) Brain Research , vol.751 , Issue.1 , pp. 165-168
    • Lee, K.1    Boden, P.2
  • 186
    • 67349132843 scopus 로고    scopus 로고
    • Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazoneinduced closure of the K(ATP) channel and insulin secretion in rats
    • Chang, T. J., W. P. Chen, C. Yang, P. H. Lu, Y. C. Liang, M. J. Su, S. C. Lee, and L. M. Chuang. 2009. Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazoneinduced closure of the K(ATP) channel and insulin secretion in rats. Diabetologia. 52:1112-1121.
    • (2009) Diabetologia , vol.52 , pp. 1112-1121
    • Chang, T.J.1    Chen, W.P.2    Yang, C.3    Lu, P.H.4    Liang, Y.C.5    Su, M.J.6    Lee, S.C.7    Chuang, L.M.8
  • 187
    • 3042714528 scopus 로고    scopus 로고
    • The prospective pioglitazone clinical trial in macrovascular events (PROactive'): Can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5,238 patients
    • DOI 10.2337/diacare.27.7.1647
    • Charbonnel, B., J. Dormandy, E. Erdmann, M. Massi-Benedetti, and A. Skene. 2004. The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients. Diabetes Care. 27:1647-1653. (Pubitemid 38857439)
    • (2004) Diabetes Care , vol.27 , Issue.7 , pp. 1647-1653
    • Charbonnel, B.1    Dormandy, J.2    Erdmann, E.3    Massi-Benedetti, M.4    Skene, A.5
  • 188
    • 77952749448 scopus 로고    scopus 로고
    • Pioglitazone use in combination with insulin in the prospective pioglitazone clinical trial in macrovascular events study (PROactive19)
    • Charbonnel, B., R. DeFronzo, J. Davidson, O. Schmitz, K. Birkeland, V. Pirags, and A. Scheen. 2010. Pioglitazone use in combination with insulin in the prospective pioglitazone clinical trial in macrovascular events study (PROactive19). J. Clin. Endocrinol. Metab. 95:2163-2171.
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 2163-2171
    • Charbonnel, B.1    DeFronzo, R.2    Davidson, J.3    Schmitz, O.4    Birkeland, K.5    Pirags, V.6    Scheen, A.7
  • 189
    • 33847675510 scopus 로고    scopus 로고
    • The Effect of Pioglitazone on Recurrent Myocardial Infarction in 2,445 Patients With Type 2 Diabetes and Previous Myocardial Infarction. Results From the PROactive (PROactive 05) Study
    • DOI 10.1016/j.jacc.2006.12.048, PII S0735109707006390
    • Erdmann, E., J. A. Dormandy, B. Charbonnel, M. Massi-Benedetti, I. K. Moules, and A. M. Skene. 2007. The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: results from the PROactive (PROactive 05) Study. J. Am. Coll. Cardiol. 49:1772-1780. (Pubitemid 46629127)
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.17 , pp. 1772-1780
    • Erdmann, E.1    Dormandy, J.A.2    Charbonnel, B.3    Massi-Benedetti, M.4    Moules, I.K.5    Skene, A.M.6
  • 190
    • 48649107300 scopus 로고    scopus 로고
    • Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: Results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
    • Dagenais, G. R., H. C. Gerstein, R. Holman, A. Budaj, A. Escalante, T. Hedner, M. Keltai, E. Lonn, S. McFarlane, M. McQueen, et al. 2008. Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial. Diabetes Care. 31:1007-1014.
    • (2008) Diabetes Care , vol.31 , pp. 1007-1014
    • Dagenais, G.R.1    Gerstein, H.C.2    Holman, R.3    Budaj, A.4    Escalante, A.5    Hedner, T.6    Keltai, M.7    Lonn, E.8    McFarlane, S.9    McQueen, M.10
  • 191
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • Gerstein, H. C., S. Yusuf, J. Bosch, J. Pogue, P. Sheridan, N. Dinccag, M. Hanefeld, B. Hoogwerf, M. Laakso, V. Mohan, et al. 2006. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet. 368:1096-1105.
    • (2006) Lancet , vol.368 , pp. 1096-1105
    • Gerstein, H.C.1    Yusuf, S.2    Bosch, J.3    Pogue, J.4    Sheridan, P.5    Dinccag, N.6    Hanefeld, M.7    Hoogwerf, B.8    Laakso, M.9    Mohan, V.10
  • 194
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials
    • DOI 10.1001/jama.298.10.1180
    • Lincoff, A. M., K. Wolski, S. J. Nicholls, and S. E. Nissen. 2007. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA. 298:1180-1188. (Pubitemid 47403104)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.10 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 195
    • 53349153475 scopus 로고    scopus 로고
    • Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials
    • Mannucci, E., M. Monami, C. Lamanna, G. F. Gensini, and N. Marchionni. 2008. Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials. Diabetes Obes. Metab. 10:1221-1238.
    • (2008) Diabetes Obes. Metab. , vol.10 , pp. 1221-1238
    • Mannucci, E.1    Monami, M.2    Lamanna, C.3    Gensini, G.F.4    Marchionni, N.5
  • 196
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen, S. E., and K. Wolski. 2010. Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch. Intern. Med. 170:1191-1201.
    • (2010) Arch. Intern. Med. , vol.170 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 197
    • 77957952617 scopus 로고    scopus 로고
    • Regulatory action on rosiglitazone by the US Food and Drug Administration
    • Woodcock, J., J. M. Sharfstein, and M. Hamburg. 2010. Regulatory action on rosiglitazone by the US Food and Drug Administration. N. Engl. J. Med. 363:1489-1491.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1489-1491
    • Woodcock, J.1    Sharfstein, J.M.2    Hamburg, M.3
  • 198
    • 74549202936 scopus 로고    scopus 로고
    • The thiazolidinediones rosiglitazone and pioglitazone and the risk of coronary heart disease: A retrospective cohort study using a US health insurance database
    • Ziyadeh, N., A. T. McAfee, C. Koro, J. Landon, and C. K. Arnold. 2009. The thiazolidinediones rosiglitazone and pioglitazone and the risk of coronary heart disease: a retrospective cohort study using a US health insurance database. Clin. Ther. 31:2665-2677.
    • (2009) Clin. Ther. , vol.31 , pp. 2665-2677
    • Ziyadeh, N.1    McAfee, A.T.2    Koro, C.3    Landon, J.4    Arnold, C.K.5
  • 199
    • 56749178443 scopus 로고    scopus 로고
    • Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy
    • Winkelmayer, W. C., S. Setoguchi, R. Levin, and D. H. Solomon. 2008. Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy. Arch. Intern. Med. 168:2368-2375.
    • (2008) Arch. Intern. Med. , vol.168 , pp. 2368-2375
    • Winkelmayer, W.C.1    Setoguchi, S.2    Levin, R.3    Solomon, D.H.4
  • 200
    • 84860117993 scopus 로고    scopus 로고
    • Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: Retrospective cohort study using UK general practice research database
    • Tzoulaki, I., M. Molokhia, V. Curcin, M. P. Little, C. J. Millett, A. Ng, R. I. Hughes, K. Khunti, M. R. Wilkins, A. Majeed, et al. 2009. Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ. 339:b4731.
    • (2009) BMJ , vol.339
    • Tzoulaki, I.1    Molokhia, M.2    Curcin, V.3    Little, M.P.4    Millett, C.J.5    Ng, A.6    Hughes, R.I.7    Khunti, K.8    Wilkins, M.R.9    Majeed, A.10
  • 202
    • 67650465654 scopus 로고    scopus 로고
    • Thiazolidinediones and cardiovascular events in patients with type 2 diabetes mellitus: A retrospective cohort study of over 473,000 patients using the National Health Insurance database in Taiwan
    • Hsiao, F. Y., W. F. Huang, Y. W. Wen, P. F. Chen, K. N. Kuo, and Y. W. Tsai. 2009. Thiazolidinediones and cardiovascular events in patients with type 2 diabetes mellitus: a retrospective cohort study of over 473,000 patients using the National Health Insurance database in Taiwan. Drug Saf. 32:675-690.
    • (2009) Drug Saf. , vol.32 , pp. 675-690
    • Hsiao, F.Y.1    Huang, W.F.2    Wen, Y.W.3    Chen, P.F.4    Kuo, K.N.5    Tsai, Y.W.6
  • 204
    • 79953203593 scopus 로고    scopus 로고
    • Comparative cardiovascular effects of thiazolidinediones: Systematic review and meta-analysis of observational studies
    • Loke, Y. K., C. S. Kwok, and S. Singh. 2011. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 342:d1309.
    • (2011) BMJ , vol.342
    • Loke, Y.K.1    Kwok, C.S.2    Singh, S.3
  • 206
    • 79955064893 scopus 로고    scopus 로고
    • Selective modulation of PPARgamma activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes
    • Dunn, F. L., L. S. Higgins, J. Fredrickson, and A. M. DePaoli. 2011. Selective modulation of PPARgamma activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes. J. Diabetes Complications. 25:151-158.
    • (2011) J. Diabetes Complications , vol.25 , pp. 151-158
    • Dunn, F.L.1    Higgins, L.S.2    Fredrickson, J.3    DePaoli, A.M.4
  • 207
    • 79960815783 scopus 로고    scopus 로고
    • A randomized- Controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes
    • Kong, A. P., A. Yamasaki, R. Ozaki, H. Saito, T. Asami, S. Ohwada, G. T. Ko, C. K. Wong, G. T. Leung, K. F. Lee, et al. 2011. A randomized- controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes. Diabetes Obes. Metab. 13:806-813.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 806-813
    • Kong, A.P.1    Yamasaki, A.2    Ozaki, R.3    Saito, H.4    Asami, T.5    Ohwada, S.6    Ko, G.T.7    Wong, C.K.8    Leung, G.T.9    Lee, K.F.10
  • 208
    • 79955730238 scopus 로고    scopus 로고
    • Efficacy and safety of the PPARgamma partial agonist balaglitazone compared with pioglitazone and placebo: A phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy
    • Henriksen, K., I. Byrjalsen, P. Qvist, H. Beck-Nielsen, G. Hansen, B. J. Riis, H. Perrild, O. L. Svendsen, J. Gram, M. A. Karsdal, et al. 2011. Efficacy and safety of the PPARgamma partial agonist balaglitazone compared with pioglitazone and placebo: a phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy. Diabetes Metab. Res. Rev. 27:392-401.
    • (2011) Diabetes Metab. Res. Rev. , vol.27 , pp. 392-401
    • Henriksen, K.1    Byrjalsen, I.2    Qvist, P.3    Beck-Nielsen, H.4    Hansen, G.5    Riis, B.J.6    Perrild, H.7    Svendsen, O.L.8    Gram, J.9    Karsdal, M.A.10
  • 211
    • 34548182594 scopus 로고    scopus 로고
    • PPAR dual agonists: Are they opening Pandora's Box?
    • DOI 10.1016/j.phrs.2007.03.002, PII S1043661807000503
    • Balakumar, P., M. Rose, S. S. Ganti, P. Krishan, and M. Singh. 2007. PPAR dual agonists: are they opening Pandora's Box? Pharmacol. Res. 56:91-98. (Pubitemid 47304493)
    • (2007) Pharmacological Research , vol.56 , Issue.2 , pp. 91-98
    • Balakumar, P.1    Rose, M.2    Ganti, S.S.3    Krishan, P.4    Singh, M.5
  • 212
    • 28144451163 scopus 로고    scopus 로고
    • Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
    • DOI 10.1001/jama.294.20.joc50147
    • Nissen, S. E., K. Wolski, and E. J. Topol. 2005. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA. 294:2581-2586. (Pubitemid 41697247)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.20 , pp. 2581-2586
    • Nissen, S.E.1    Wolski, K.2    Topol, E.J.3
  • 213
    • 60049088271 scopus 로고    scopus 로고
    • Rat urinary bladder carcinogenesis by dual-acting PPARalpha + gamma agonists
    • Oleksiewicz, M. B., J. Southgate, L. Iversen, and F. L. Egerod. 2008. Rat urinary bladder carcinogenesis by dual-acting PPARalpha + gamma agonists. PPAR Res. 2008:103167.
    • (2008) PPAR Res. , vol.2008 , pp. 103167
    • Oleksiewicz, M.B.1    Southgate, J.2    Iversen, L.3    Egerod, F.L.4
  • 214
    • 79956087344 scopus 로고    scopus 로고
    • Pharmacokinetics, effi cacy and safety of aleglitazar for the treatment of type 2 diabetes with high cardiovascular risk
    • Younk, L. M., L. Uhl, and S. N. Davis. 2011. Pharmacokinetics, effi cacy and safety of aleglitazar for the treatment of type 2 diabetes with high cardiovascular risk. Expert Opin. Drug Metab. Toxicol. 7: 753-763.
    • (2011) Expert Opin. Drug Metab. Toxicol. , vol.7 , pp. 753-763
    • Younk, L.M.1    Uhl, L.2    Davis, S.N.3
  • 217
    • 67649852314 scopus 로고    scopus 로고
    • PPAR-alpha and PPAR-gamma agonists for type 2 diabetes
    • Charbonnel, B. 2009. PPAR-alpha and PPAR-gamma agonists for type 2 diabetes. Lancet. 374:96-98.
    • (2009) Lancet , vol.374 , pp. 96-98
    • Charbonnel, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.