-
1
-
-
1442352339
-
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
-
DOI 10.1210/jc.2003-030723
-
Bays H, Mandarino L, DeFronzo RA 2004 Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 89: 463-478 (Pubitemid 38269844)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.2
, pp. 463-478
-
-
Bays, H.1
Mandarino, L.2
Defronzo, R.A.3
-
2
-
-
0037567697
-
Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes
-
Bajaj M, Suraamornkul S, Pratipanawatr T, Hardies LJ, Pratipanawatr W, Glass L, Cersosimo E, Miyazaki Y, DeFronzo RA 2003 Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes. Diabetes 52: 1364-1370
-
(2003)
Diabetes
, vol.52
, pp. 1364-1370
-
-
Bajaj, M.1
Suraamornkul, S.2
Pratipanawatr, T.3
Hardies, L.J.4
Pratipanawatr, W.5
Glass, L.6
Cersosimo, E.7
Miyazaki, Y.8
DeFronzo, R.A.9
-
3
-
-
0036072223
-
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients
-
Miyazaki Y, Mahankali A, Matsuda M, Mahankali S, Hardies J, Cusi K, Mandarino LJ, DeFronzo RA 2002 Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 87:2784-2791
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 2784-2791
-
-
Miyazaki, Y.1
Mahankali, A.2
Matsuda, M.3
Mahankali, S.4
Hardies, J.5
Cusi, K.6
Mandarino, L.J.7
DeFronzo, R.A.8
-
4
-
-
0036310037
-
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
-
Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF 2002 The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51:797-802
-
(2002)
Diabetes
, vol.51
, pp. 797-802
-
-
Mayerson, A.B.1
Hundal, R.S.2
Dufour, S.3
Lebon, V.4
Befroy, D.5
Cline, G.W.6
Enocksson, S.7
Inzucchi, S.E.8
Shulman, G.I.9
Petersen, K.F.10
-
5
-
-
3242745192
-
Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
-
Tiikkainen M, Häkkinen AM, Korsheninnikova E, Nyman T, Mäkimattila S, Yki-Järvinen H 2004 Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 53:2169-2176
-
(2004)
Diabetes
, vol.53
, pp. 2169-2176
-
-
Tiikkainen, M.1
Häkkinen, A.M.2
Korsheninnikova, E.3
Nyman, T.4
Mäkimattila, S.5
Yki-Järvinen, H.6
-
6
-
-
17444420663
-
Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue
-
Rasouli N, Raue U, Miles LM, Lu T, Di Gregorio GB, Elbein SC, Kern PA 2005 Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue. Am J Physiol Endocrinol Metab 288:E930-E934
-
(2005)
Am J Physiol Endocrinol Metab
, vol.288
-
-
Rasouli, N.1
Raue, U.2
Miles, L.M.3
Lu, T.4
Di Gregorio, G.B.5
Elbein, S.C.6
Kern, P.A.7
-
7
-
-
33644695097
-
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients
-
Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA 2005 Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients. Diabetes 54:3148-3153
-
(2005)
Diabetes
, vol.54
, pp. 3148-3153
-
-
Bajaj, M.1
Suraamornkul, S.2
Romanelli, A.3
Cline, G.W.4
Mandarino, L.J.5
Shulman, G.I.6
DeFronzo, R.A.7
-
8
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI 2002 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277: 50230-50236
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
Zhang, D.4
Zong, H.5
Wang, Y.6
Bergeron, R.7
Kim, J.K.8
Cushman, S.W.9
Cooney, G.J.10
Atcheson, B.11
White, M.F.12
Kraegen, E.W.13
Shulman, G.I.14
-
9
-
-
27244440736
-
Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
-
Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, Cline GW, Pongratz RL, Zhang XM, Choi CS, Coleman RA, Shulman GI 2005 Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab 2:55-65
-
(2005)
Cell Metab
, vol.2
, pp. 55-65
-
-
Neschen, S.1
Morino, K.2
Hammond, L.E.3
Zhang, D.4
Liu, Z.X.5
Romanelli, A.J.6
Cline, G.W.7
Pongratz, R.L.8
Zhang, X.M.9
Choi, C.S.10
Coleman, R.A.11
Shulman, G.I.12
-
10
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-α
-
Itani SI, Ruderman NB, Schmieder F, Boden G 2002 Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-α. Diabetes 51:2005-2011 (Pubitemid 34729001)
-
(2002)
Diabetes
, vol.51
, Issue.7
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
11
-
-
0018520840
-
Glucose clamp technique: A method for quantifying insulin secretion and resistance
-
DeFronzo RA, Tobin JD, Andres R 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
-
(1979)
Am J Physiol
, vol.237
-
-
DeFronzo, R.A.1
Tobin, J.D.2
Andres, R.3
-
12
-
-
0032934826
-
Intramyocellular lipid concentrations are associated with insulin sensitivity in humans: A 1H NMR spectroscopy study
-
Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI 1999 Intramyocellular lipid concentrations are associated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113-116
-
(1999)
Diabetologia
, vol.42
, pp. 113-116
-
-
Krssak, M.1
Falk Petersen, K.2
Dresner, A.3
DiPietro, L.4
Vogel, S.M.5
Rothman, D.L.6
Roden, M.7
Shulman, G.I.8
-
13
-
-
0000648085
-
Influence of glucose loading and of injected insulin on hepatic glucose output
-
Steele R 1959 Influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82:420-430
-
(1959)
Ann NY Acad Sci
, vol.82
, pp. 420-430
-
-
Steele, R.1
-
14
-
-
10244251720
-
Variance-modeled posterior inference of microarray data: Detecting gene-expression changes in 3T3-L1 adipocytes
-
Hsiao A, Worrall DS, Olefsky JM, Subramaniam S 2004 Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes. Bioinformatics 20:3108-3127
-
(2004)
Bioinformatics
, vol.20
, pp. 3108-3127
-
-
Hsiao, A.1
Worrall, D.S.2
Olefsky, J.M.3
Subramaniam, S.4
-
15
-
-
21544466158
-
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
-
Goldberg RB, Kendall DM, Deeg MA, Buse JB, Zagar AJ, Pinaire JA, Tan MH, Khan MA, Perez AT, Jacober SJ 2005 A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care 28: 1547-1554
-
(2005)
Diabetes Care
, vol.28
, pp. 1547-1554
-
-
Goldberg, R.B.1
Kendall, D.M.2
Deeg, M.A.3
Buse, J.B.4
Zagar, A.J.5
Pinaire, J.A.6
Tan, M.H.7
Khan, M.A.8
Perez, A.T.9
Jacober, S.J.10
-
16
-
-
0842313004
-
Decreased Plasma Adiponectin Concentrations Are Closely Related to Hepatic Fat Content and Hepatic Insulin Resistance in Pioglitazone-Treated Type 2 Diabetic Patients
-
DOI 10.1210/jc.2003-031315
-
Bajaj M, Suraamornkul S, Piper P, Hardies LJ, Glass L, Cersosimo E, Pratipanawatr T, Miyazaki Y, DeFronzo RA 2004 Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients. J Clin Endocrinol Metab 89:200-206 (Pubitemid 38183882)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.1
, pp. 200-206
-
-
Bajaj, M.1
Suraamornkul, S.2
Piper, P.3
Hardies, L.J.4
Glass, L.5
Cersosimo, E.6
Pratipanawatr, T.7
Miyazaki, Y.8
Defronzo, R.A.9
-
17
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T 2001 The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946
-
(2001)
Nat Med
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
Terauchi, Y.4
Kubota, N.5
Hara, K.6
Mori, Y.7
Ide, T.8
Murakami, K.9
Tsuboyama-Kasaoka, N.10
Ezaki, O.11
Akanuma, Y.12
Gavrilova, O.13
Vinson, C.14
Reitman, M.L.15
Kagechika, H.16
Shudo, K.17
Yoda, M.18
Nakano, Y.19
Tobe, K.20
Nagai, R.21
Kimura, S.22
Tomita, M.23
Froguel, P.24
Kadowaki, T.25
more..
-
18
-
-
34447114640
-
Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus
-
Bajaj M, Suraamornkul S, Hardies LJ, Glass L, Musi N, DeFronzo RA 2007 Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus. Diabetologia 50:1723-1731
-
(2007)
Diabetologia
, vol.50
, pp. 1723-1731
-
-
Bajaj, M.1
Suraamornkul, S.2
Hardies, L.J.3
Glass, L.4
Musi, N.5
DeFronzo, R.A.6
-
19
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T 2002 Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288-1295
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
Eto, K.11
Akanuma, Y.12
Froguel, P.13
Foufelle, F.14
Ferre, P.15
Carling, D.16
Kimura, S.17
Nagai, R.18
Kahn, B.B.19
Kadowaki, T.20
more..
-
20
-
-
0035671770
-
Effect of rosiglitazone on glucose and free fatty acid metabolism in type 2 diabetic patients
-
Miyazaki Y, Glass L, Triplitt C, Matsuda M, Cusi K, Mahankali A, Mahankali S, Mandarino LJ, DeFronzo RA 2001 Effect of rosiglitazone on glucose and free fatty acid metabolism in type 2 diabetic patients. Diabetologia 44:2210-2219
-
(2001)
Diabetologia
, vol.44
, pp. 2210-2219
-
-
Miyazaki, Y.1
Glass, L.2
Triplitt, C.3
Matsuda, M.4
Cusi, K.5
Mahankali, A.6
Mahankali, S.7
Mandarino, L.J.8
DeFronzo, R.A.9
-
21
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI 1999 Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103:253-259
-
(1999)
J Clin Invest
, vol.103
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
Griffin, M.E.4
Dufour, S.5
Cline, G.W.6
Slezak, L.A.7
Andersen, D.K.8
Hundal, R.S.9
Rothman, D.L.10
Petersen, K.F.11
Shulman, G.I.12
-
22
-
-
8544244084
-
PKC-θ knockout mice are protected from fat-induced insulin resistance
-
Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI 2004 PKC-θ knockout mice are protected from fat-induced insulin resistance. J Clin Invest 114:823-827
-
(2004)
J Clin Invest
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
Fillmore, J.J.2
Sunshine, M.J.3
Albrecht, B.4
Higashimori, T.5
Kim, D.W.6
Liu, Z.X.7
Soos, T.J.8
Cline, G.W.9
O'Brien, W.R.10
Littman, D.R.11
Shulman, G.I.12
-
23
-
-
33847347318
-
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration
-
Bajaj M, Medina-Navarro R, Suraamornkul S, Meyer C, DeFronzo RA, Mandarino LJ 2007 Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration. Diabetes 56:743-752
-
(2007)
Diabetes
, vol.56
, pp. 743-752
-
-
Bajaj, M.1
Medina-Navarro, R.2
Suraamornkul, S.3
Meyer, C.4
DeFronzo, R.A.5
Mandarino, L.J.6
|