Inhibition of K(ATP) channel activity by troglitazone in CRI-G1 insulin-secreting cells

European Journal of Pharmacology

Volumn 313, Issue 1-2, 1996, Pages 163-167

  Lee, Kevin ^a   Ibbotson, Tim ^a   Richardson, Peter J ^a   Boden, Philip R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Insulin secretion; K(ATP) channel; Troglitazone; Cell

Indexed keywords

POTASSIUM CHANNEL; TOLBUTAMIDE; TROGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; CHROMAN DERIVATIVE; INSULIN; POTASSIUM CHANNEL BLOCKING AGENT; THIAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; INSULIN RELEASE; INSULINOMA; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; TECHNIQUE; ANIMAL; CELL CULTURE; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; METABOLISM; PANCREAS ISLET; SECRETION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; CHROMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; RATS; THIAZOLES; THIAZOLIDINEDIONES; TOLBUTAMIDE;

EID: 0030578930     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00619-X     Document Type: Article

References (14)

1. Carrington, C.A., E.D. Rubery, E.C. Pearson and C.N. Hales, 1986, Five new insulin-producing cell lines with differing secretory properties, J. Endocrinol. 109, 193-200.
2. Dempster, J., 1988, Computer analysis of electrophysiological signals, in: Microcomputers in Physiology, A Practical Approach, ed. P.J. Fraser (IRL Press, Oxford) p. 51-95.
3. Fujiwara, T., S. Yoshioka, T., Yoshioka, I. Ushiyama and H. Horikoshi, 1988, Characterisation of new oral antidiabetic agent CS-045, Diabetes 37, 1549-1558.
4. Fujiwara, T., M. Wada, K. Fukuda, M. Fukami, S. Yoshioka, T. Yoshioka and H. Horikoshi, 1991, Characterisation of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice, Metabolism 40, 1213-1218.
5. Hamill, O.P., A. Marty, E. Neher, B. Sakmann and F.J. Sigworth, 1981, Improved patch clamp techniques for high resolution current recording from cells and cell free membrane patches, Pflügers Arch. 391, 85-100.
6. + currents recorded from an insulin-secreting cell line, Br. J. Pharmacol. 97, 1039-1050.
7. ATP channels by sulphonylureas in CRI-G1 insulin secreting cells, Br. J. Pharmacol. 111, 632-640.
8. Masuda, K., Y. Okamoto, Y. Tsuura, S. Kato, T. Miura, K. Tsuda, H. Horikoshi, H. Ishida and Y. Seino, 1995, Effects of troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide, Diabetologia 38, 24-30.
9. + channels in cardiac muscle, Nature 305, 147-148.
10. Pershadsingh, H.A., J. Szollosi, S, Benson, W.C. Hyun, E.G. Feuerstein and T.W. Kurtz, 1993, Effects of ciglitazone on blood pressure and intracellular calcium metabolism, Hypertension 21, 1020-1023.
11. + channel in mouse pancreatic β-cells, Pflügers Arch. 407, 493-499.
12. Whitcomb, R.W. and A.R. Saltiel, 1995, Thiazolidinediones, Exp. Opin. Invest. Drugs 4, 1299-1309.
13. Zhang, H.-Y., S.R. Reddt and T.A. Kotchen, 1994, Antihypertensive effect of pioglitazone is not invariably associated with increased insulin sensitivity, Hypertension 24, 106-110.
14. + currents in pancreatic B-cells, Naunyn-Schmiedebergs Arch. Pharmacol. 337, 225-230.