Leptospiral hemolysins induce proinflammatory cytokines through toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Wang, Huan ^a,b   Wu, Yifei ^a   Ojcius, David M ^c   Yang, X Frank ^d   Zhang, Chenglin ^a   Ding, Shibiao ^a   Lin, Xu'ai ^a   Yan, Jie ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOLYSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; JANUS KINASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ADULT; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; CASE REPORT; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENETIC TRANSCRIPTION; HEMOLYSIS; HLPA GENE; HLYC GENE; HLYX GENE; HUMAN; HUMAN CELL; INFLAMMATION; LEPTOSPIRA; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; MACROPHAGE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SPH1 GENE; SPH2 GENE; SPH3 GENE; SPH4 GENE; TLYA GENE;

ADULT; ANIMALS; CELL LINE; CYTOKINES; FEMALE; HEMOLYSIN PROTEINS; HUMANS; INFLAMMATION MEDIATORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; MACROPHAGES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; NF-KAPPA B; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

LEPTOSPIRA; LEPTOSPIRA INTERROGANS; MUS;

EID: 84864760198     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042266     Document Type: Article

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