Subcytocidal attack by staphylococcal alpha-toxin activates NF-κB and induces interleukin-8 production

Infection and Immunity

Volumn 69, Issue 4, 2001, Pages 2630-2635

  Dragneva, Y ^a   Anuradha, C D ^a   Valeva, A ^a   Hoffmann, A ^a   Bhakdi, S ^a   Husmann, M ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; BACTERIAL TOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ELECTROPHORESIS; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INFLAMMATION; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; STAPHYLOCOCCUS; TARGET CELL;

ADENOSINE TRIPHOSPHATE; BACTERIAL TOXINS; CELL LINE; HEMOLYSIN PROTEINS; HUMANS; INTERLEUKIN-8; NF-KAPPA B; PROMOTER REGIONS (GENETICS); STAPHYLOCOCCUS;

EID: 0035085993     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.4.2630-2635.2001     Document Type: Article

References (27)

1. Control of apoptosis by Rel/NF-κB transcription factors
2. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
3. Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: Prototypes of pore-forming bacterial cytolysins
4. Release of interleukin-1 beta associated with potent cytocidal action of staphylococcal alpha-toxin on human monocytes
5. Effects of Escherichia coli hemolysin on human monocytes. Cytocidal action and stimulation of interleukin 1 release
6. Alpha-toxin of Staphylococcus aureus
7. Interaction with a lipid membrane: A key step in bacterial toxins virulence
8. NF-κB to the rescue: RELs, apoptosis and cellular transformation
9. Regulation of inducible gene expression by the transcription factor NF-κB
10. The Rel/NF-κB signal transduction pathway: Introduction
11. Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin
12. Novel path to apoptosis: Small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation
13. Histidine residues near the N terminus of staphylococcal alpha-toxin as reporters of regions that are critical for oligomerization and pore formation
14. Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κB activation
15. Activation of human effector cells by different bacterial toxins (leukocidin, alveolysin, and erythrogenic toxin A): Generation of interleukin-8
16. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (RelA) and NF-IL-6
17. NF-κB subunit-specific regulation of the interleukin-8 promoter
18. Thiol agents and Bcl-2 identify, an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-κB
19. Genomic organization and transcriptional regulation of the RANTES chemokine gene
20. Activators and target genes of Rel/NF-κB transcription factors
21. Staphylococcus aureus alpha-toxin. Production of functionally intact, site-specifically modifiable protein by introduction of cysteine at positions 69, 130, and 186
22. Oxidant stress regulation of IL-8 and ICAM-1 gene expression: Differential activation and binding of the transcription factors AP-1 and NF-κB
23. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
24. Staphylococcal alpha-toxin: Repair of a calcium-impermeable pore in the target cell membrane
25. Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions
26. Recovery of human fibroblasts from attack by the pore-forming alpha-toxin of Staphylococcus aureus
27. Potassium-inhibited processing of IL-1 beta in human monocytes