Evidence for endotoxin as a causative factor for leptospiral uveitis in humans

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 12, 2008, Pages 5419-5424

  Priya, Chidambaranathan Gowri ^a   Rathinam, Sivakumar R ^b   Muthukkaruppan, Veerappan ^a  

^a ARAVIND MEDICAL RESEARCH FOUNDATION   (India)

^b ARAVIND EYE HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR; CYTOKINE;

ADULT; AGGLUTINATION TEST; AQUEOUS HUMOR; ARTICLE; BEHCET DISEASE; BLOOD SAMPLING; CATARACT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMETRY; DOT HYBRIDIZATION; EOSINOPHIL; FEMALE; GRAM NEGATIVE BACTERIUM; HUMAN; LEPTOSPIRAL UVEITIS; LEPTOSPIROSIS; LIMULUS LYSATE TEST; LYMPHOCYTIC INFILTRATION; MACROPHAGE ACTIVATION; MALE; MONOCYTE; NEUTROPHIL CHEMOTAXIS; PHACOLYTIC UVEITIS; PRIORITY JOURNAL; SEROTYPE; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; UVEITIS; BACTERIAL EYE INFECTION; ISOLATION AND PURIFICATION; LEPTOSPIRA; METABOLISM; MICROBIOLOGY;

AGGLUTINATION TESTS; AQUEOUS HUMOR; CYTOKINES; EYE INFECTIONS, BACTERIAL; HUMANS; LEPTOSPIRA; LEPTOSPIROSIS; LIMULUS TEST; LIPOPOLYSACCHARIDES; UVEITIS;

EID: 58149265647     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2174     Document Type: Article

References (35)

1. Sturman RM, Laval J, Weil VJ. Leptospiral uveitis. Am J Ophthalmol. 1949;32:1564-1566.
2. Rathinam SR, Rathnam S, Selvaraj S, Dean D, Nozik RA, Namperumalsamy P. Uveitis associated with an epidemic outbreak of leptospirosis. Am J Ophthalmol. 1997;124:71-79. (Pubitemid 27298993)
3. Rathinam S, Ratnam S, Sureshbabu L, Natarajaseenivasan K. Leptospiral antibodies in patients with recurrent ophthalmic involvement. Indian J Med Res. 1996;103:66-68. (Pubitemid 26030891)
4. Priya CG, Bhavani K, Rathinam SR, Muthukkaruppan VR. Identification and evaluation of LPS antigen for serodiagnosis of uveitis associated with leptospirosis. J Med Microbiol. 2003;52:667-673. (Pubitemid 36981474)
5. Plank SR, Huang XN, Robertson JE, Rosenbaum JT. Cytokine mRNA levels in rat ocular tissues after systemic endotoxin treatment. Invest Ophthalmol Vis Sci. 1994;35(3):924-930.
6. Guex-Crosier Y, Wittwer AJ, Roberge FG. Intraocular production of a cytokine (CINC) responsible for neutrophil infiltration in endotoxin induced uveitis. Br J Ophthalmol. 1996;80:649-653. (Pubitemid 26258152)
7. Samples JR, Boney RS, Rosenbaum JT. Ocular inflammatory effects of intravitreally injected interleukin-2. Curr Eye Res. 1993;12:649-654.
8. Lee SF, Pepose JS. Cellular immune response to Ia induction by intraocular gamma-interferon. Ophthalmic Res. 1990;22:310-317. (Pubitemid 20383303)
9. Rathinam SR. Studies on Clinical Presentation, Diagnosis and Management of Infectious Uveitis with Reference to Leptospirosis. PhD thesis. Chennai, India: MGR University; 2006.
10. Bloch-Michel E, Nussenblatt RB. International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol. 1987;103:234-235.
11. Nussenblatt RB, Whitcup SM, Palestine AG. Examination of the patient with uveitis: Nussenblatt RB. Whitcup SM, Palestine AG, eds. Uveitis: Fundamentals and Clinical Practice. 2nd ed. St. Louis: Mosby; 1996:58-68.
12. Terpstra WJ, Lighart GS, Schoone GJ. ELISA for the detection of specific IgM and IgG in human leptospirosis. J Gen Microbiol. 1985;131:377-385.
13. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
15. Verma MJ, Lloyd A, Rager H, et al. Chemokines in acute anterior uveitis. Curr Eye Res. 1997;16:1202-1208.
16. el-Shabrawi Y, Livir-Rallatos C, Christen W, Baltatzis S, Foster CS. High levels of interleukin-12 in the aqueous humor and vitreous of patients with uveitis. Ophthalmol. 1998;105:1659-1663.
17. Lacomba MS, Martin CM, Chamond RR, Galera JM, Omar M, Estevez EC. Aqueous humor and serum interferon-γ, interleukin (IL) 2, IL-4 and IL-10 in patients with uveitis. Arch Ophthalmol. 2000;118:768-772. (Pubitemid 30395172)
18. Curnow SJ, Falciani F, Durrani OM, et al. Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis. Invest Ophthalmol Vis Sci. 2005;46(11):4251-4259. (Pubitemid 44264629)
19. Ooi KGJ, Galatowicz G, Towler HMA, Lightman SL, Calder VL. Multiplex cytokine detection versus ELISA for aqueous humor: IL-5, IL-10 and IFNγ profiles in uveitis. Invest Ophthalmol Vis Sci. 2006;47:272-277. (Pubitemid 46780824)
20. Norose K, Yano A, Wang XC, et al. Dominance of activated T cells and interleukin-6 in AH in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 1994;35:33-39. (Pubitemid 24046825)
21. Ongkosuwito JV, Feron EJ, van Doornik CE, et al. Analysis of immunoregulatory cytokines in ocular fluid samples from patients with uveitis. Invest Ophthalmol Vis Sci. 1998;39:2659-2665.
22. Takase H, Futagami Y, Yoshida T, et al. Cytokine profile in aqueous humor and sera of patients with infectious or noninfectious uveitis. Invest Ophthalmol Vis Sci. 2006;47(4):1557-1561. (Pubitemid 46780765)
23. Krause U, Raunio V. The proteins of the pathologic human aqueous humor: an in vivo investigation. Ophthalmologica. 1970;160:280-287.
24. de Fost M, Hartskeerl RA, Groenendijk MR, van der Poll T. Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans. Clin Diagn Lab Immunol. 2003;10(2):332-335.
25. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR. Endotoxin-induced uveitis in rats as a model for human disease. Nature. 1980;286:611-613. (Pubitemid 10015368)
26. Wacker WB. Proctor Lecture. Experimental allergic uveitis: investigations of retinal autoimmunity and the immunopathologic responses evoked. Invest Ophthalmol Vis Sci. 1991;32:3119-3128.
27. de Vos AF, van Haren MA, Verhagen C, Hoekzema R, Kijlstra A. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest Ophthalmol Vis Sci. 1994;35:1100-1106. (Pubitemid 24079844)
28. Howes EL Jr, Hoffman MA, Ulevitch RJ, Mathison JC, Morrison DC. Ocular localization of circulating bacterial lipopolysaccharide. Exp Eye Res. 1984;38(4):379-389.
29. Ohta K, Wiggert B, Taylor AW, Streilein JW. Effects of experimental ocular inflammation on ocular immune privilege. Invest Ophthalmol Vis Sci. 1999;40:2010-2018. (Pubitemid 29365164)
30. Faine S, Adler B, Bolin C, Perolat P. Leptospira and Leptospirosis. 2nd ed. Melbourne, Australia: MediSci; 1999.
31. Isogai E, Isogai H, Fujii N, Oguma K. Macrophage activation by leptospiral lipopolysaccharide. Zent Bakt. 1990;273:200-208.
32. Nally JE, Chow E, Fishbein MC, Blanco DR, Lovett MA. Changes in lipopolysaccharide O antigen distinguish acute versus chronic Leptospira interrogans infections. Infect Immun. 2005;73(6):3251-3260. (Pubitemid 40745864)
33. Sakane T, Takeno M, Suzuki N, Inaba G. Bechet's disease. N Engl J Med. 1999;341(17):1284-1291.
34. Shimada K, Yaoita H, Shikano S. Chemotactic activity for polymorphonuclear leucocytes of the aqueous humor in patients with Behcet's disease. Nippon Ganka Gakkai Zasshi. 1971;75(10):2100-2105.
35. Flocks M, Littwin CS, Zimmerman LE. Phacolytic glaucoma: a clinicopathologic study of one hundred thirty-eight cases of glaucoma associated with hypermature cataract. AMA Arch Ophthalmol. 1955;54:37-45.