Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 43913-43924

  Lynagh, Timothy ^a,c   Webb, Timothy I ^a,d   Dixon, Christine L ^a   Cromers, Brett A ^b   Lynch, Joseph W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b RMIT UNIVERSITY   (Australia)

^c DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^d DUNDALK INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURANS; BINDING INTERACTION; BINDING ORIENTATION; CAENORHABDITIS ELEGANS; CHLORIDE CHANNELS; DOCKING SIMULATIONS; GLYCINE RECEPTOR; H-BONDS; HIGH EFFICACY; IVERMECTIN; LOOP RESIDUES; MOLECULAR DETERMINANTS; NANOMOLAR; SITE DIRECTED MUTAGENESIS; TRANSMEMBRANES; VAN DER WAALS INTERACTIONS;

AMINO ACIDS; BINDING ENERGY; CHLORINE COMPOUNDS; ELECTROPHYSIOLOGY; MUTAGENESIS; VAN DER WAALS FORCES;

CRYSTAL ORIENTATION;

ALANINE; ALPHA1 GLYCINE RECEPTOR; CHLORIDE CHANNEL; CYSTEINE; GLUTAMATE GATED CHLORIDE CHANNEL RECEPTOR; GLYCINE RECEPTOR; IVERMECTIN; LEUCINE; MEMBRANE RECEPTOR; PROLINE; SELAMECTIN; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DRUG INTERACTION; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; DRUG STRUCTURE; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR DOCKING; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALS; ANTIPARASITIC AGENTS; BENZOFURANS; CAENORHABDITIS ELEGANS; CHLORIDE CHANNELS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ELECTROPHYSIOLOGY; GLYCINE; HYDROGEN BONDING; IVERMECTIN; MUTAGENESIS, SITE-DIRECTED; MUTATION; RECEPTORS, GLYCINE;

EID: 83755162397     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.262634     Document Type: Article

References (46)

1. Omura, S. (2008) Int. J. Antimicrob. Agents 31, 91-98
2. Cully, D. F., Vassilatis, D. K., Liu, K. K., Paress, P. S., Van der Ploeg, L. H., Schaeffer, J. M., and Arena, J. P. (1994) Nature 371, 707-711
3. Wolstenholme, A. J., and Rogers, A. T. (2005) Parasitology 131, S85-S95
4. Awadzi, K., Boakye, D. A., Edwards, G., Opoku, N. O., Attah, S. K., Osei-Atweneboana, M. Y., Lazdins-Helds, J. K., Ardrey, A. E., Addy, E. T., Quartey, B. T., Ahmed, K., Boatin, B. A., and Soumbey-Alley, E. W. (2004) Ann. Trop. Med. Parasitol. 98, 231-249
5. Bourguinat, C., Pion, S. D., Kamgno, J., Gardon, J., Duke, B. O., Boussinesq, M., and Prichard, R. K. (2007) PLoS Negl. Trop. Dis. 1, e72
6. Osei-Atweneboana, M. Y., Eng, J. K., Boakye, D. A., Gyapong, J. O., and Prichard, R. K. (2007) Lancet 369, 2021-2029
7. Kane, N. S., Hirschberg, B., Qian, S., Hunt, D., Thomas, B., Brochu, R., Ludmerer, S. W., Zheng, Y., Smith, M., Arena, J. P., Cohen, C. J., Schmatz, D., Warmke, J., and Cully, D. F. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 13949-13954
8. Kwon, D. H., Yoon, K. S., Clark, J. M., and Lee, S. H. (2010) Insect Mol. Biol. 19, 583-591
9. Njue, A. I., Hayashi, J., Kinne, L., Feng, X. P., and Prichard, R. K. (2004) J. Neurochem. 89, 1137-1147
10. Hibbs, R. E., and Gouaux, E. (2011) Nature 474, 54-60
11. Adelsberger, H., Lepier, A., and Dudel, J. (2000) Eur. J. Pharmacol. 394, 163-170
12. Shan, Q., Haddrill, J. L., and Lynch, J. W. (2001) J. Biol. Chem. 276, 12556-12564
13. Krause, R. M., Buisson, B., Bertrand, S., Corringer, P. J., Galzi, J. L., Changeux, J. P., and Bertrand, D. (1998) Mol. Pharmacol. 53, 283-294
14. Raymond, V., Mongan, N. P., and Sattelle, D. B. (2000) Neuroscience 101, 785-791
15. Hilf, R. J., and Dutzler, R. (2008) Nature 452, 375-379
16. Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., van Der Oost, J., Smit, A. B., and Sixma, T. K. (2001) Nature 411, 269-276
17. Nevin, S. T., Cromer, B. A., Haddrill, J. L., Morton, C. J., Parker, M. W., and Lynch, J. W. (2003) J. Biol. Chem. 278, 28985-28992
18. Trott, O., and Olson, A. J. (2010) J. Comput. Chem. 31, 455-461
19. Gilbert, D. F., Islam, R., Lynagh, T., Lynch, J. W., and Webb, T. I. (2009) Front. Mol. Neurosci. 2, 17
20. Lynch, J. W., Han, N. L., Haddrill, J., Pierce, K. D., and Schofield, P. R. (2001) J. Neurosci. 21, 2589-2599
21. Lynagh, T., and Lynch, J. W. (2010) J. Biol. Chem. 285, 14890-14897
22. Perkins, D. I., Trudell, J. R., Crawford, D. K., Alkana, R. L., and Davies, D. L. (2008) J. Neurochem. 106, 1337-1349
23. Perkins, D. I., Trudell, J. R., Crawford, D. K., Asatryan, L., Alkana, R. L., and Davies, D. L. (2009) J. Biol. Chem. 284, 27304-27314
24. Miller, P. S., and Smart, T. G. (2010) Trends Pharmacol. Sci. 31, 161-174
25. Lynagh, T., and Lynch, J. W. (2010) Int. J. Parasitol. 40, 1477-1481
26. Bali, M., Jansen, M., and Akabas, M. H. (2009) J. Neurosci. 29, 3083-3092
27. Li, G. D., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. W., and Cohen, J. B. (2006) J. Neurosci. 26, 11599-11605
28. Unwin, N. (2005) J. Mol. Biol. 346, 967-989
29. Bertaccini, E. J., Wallner, B., Trudell, J. R., and Lindahl, E. (2010) J. Chem. Inf. Model. 50, 2248-2255
30. Krasowski, M. D., Koltchine, V. V., Rick, C. E., Ye, Q., Finn, S. E., and Harrison, N. L. (1998) Mol. Pharmacol. 53, 530-538
31. Ueno, S., Lin, A., Nikolaeva, N., Trudell, J. R., Mihic, S. J., Harris, R. A., and Harrison, N. L. (2000) Br. J. Pharmacol. 131, 296-302
32. Navedo, M., Nieves, M., Rojas, L., and Lasalde-Dominicci, J. A. (2004) Biochemistry 43, 78-84
33. Otero-Cruz, J. D., Báez-Pagán, C. A., Caraballo- González, I. M., and Lasalde-Dominicci, J. A. (2007) J. Biol. Chem. 282, 9162-9171
34. Silberberg, S. D., Li, M., and Swartz, K. J. (2007) Neuron 54, 263-274
35. Pan, Z. H., Zhang, D., Zhang, X., and Lipton, S. A. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 6490-6495
36. Lobo, I. A., and Harris, R. A. (2005) Int. Rev. Neurobiol. 65, 53-87
37. Webb, T. I., and Lynch, J. W. (2007) Curr. Pharm. Des. 13, 2350-2367
38. Hosie, A. M., Wilkins, M. E., da Silva, H. M., and Smart, T. G. (2006) Nature 444, 486-489
39. Michael, B., Meinke, P. T., and Shoop, W. (2001) J. Parasitol. 87, 692-696
40. McCavera, S., Rogers, A. T., Yates, D. M., Woods, D. J., and Wolstenholme, A. J. (2009) Mol. Pharmacol. 75, 1347-1355
41. Deleted in proof
42. Mrozik, H., Eskola, P., Fisher, M. H., Egerton, J. R., Cifelli, S., and Ostlind, D. A. (1982) J. Med. Chem. 25, 658-663
43. Forrester, S. G., Prichard, R. K., Dent, J. A., and Beech, R. N. (2003) Mol. Biochem. Parasitol. 129, 115-121
44. Cederholm, J. M., Schofield, P. R., and Lewis, T. M. (2009) Eur. Biophys. J. 39, 37-49
45. Choe, S., Stevens, C. F., and Sullivan, J. M. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 12046-12049
46. Greenfield, L. J., Jr., Zaman, S. H., Sutherland, M. L., Lummis, S. C., Niemeyer, M. I., Barnard, E. A., and Macdonald, R. L. (2002) Neuropharmacology 42, 502-521