Modulation of P2X 7 receptor functions by polymyxin B: Crucial role of the hydrophobic tail of the antibiotic molecule

British Journal of Pharmacology

Volumn 150, Issue 4, 2007, Pages 445-454

  Ferrari, D ^a   Pizzirani, C ^a   Gulinelli, S ^a   Callegari, G ^a   Chiozzi, P ^a   Idzko, M ^b   Panther, E ^b   Di Virgilio, F ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Endotoxin; Extracellular ATP; P2 receptors; P2X 7; Polymyxin B

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; ANTIBIOTIC AGENT; CALCIUM ION; LACTATE DEHYDROGENASE; MEMBRANE RECEPTOR; NUCLEOTIDE; POLYMYXIN B; POLYMYXIN B NONAPEPTIDE; PURINE P2X7 RECEPTOR; ANTIINFECTIVE AGENT; CALCIUM; DRUG DERIVATIVE; GREEN FLUORESCENT PROTEIN; PURINE P2 RECEPTOR;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM TRANSPORT; CAPPING PHENOMENON; CELL FUSION; CELL LINE; CELL MEMBRANE; CELL STRAIN HEK293; CELL STRUCTURE; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DEACETYLATION; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; MACROPHAGE; MEMBRANE PERMEABILITY; MICROSCOPY; PRIORITY JOURNAL; RECEPTOR AFFINITY; CELL MEMBRANE PERMEABILITY; CELL SHAPE; CHEMISTRY; METABOLISM; PHYSIOLOGY; POROSITY; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANTI-BACTERIAL AGENTS; BLOTTING, WESTERN; CALCIUM; CELL FUSION; CELL LINE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SHAPE; CYTOPLASM; GREEN FLUORESCENT PROTEINS; HUMANS; L-LACTATE DEHYDROGENASE; MACROPHAGES; POLYMYXIN B; POROSITY; RECEPTORS, PURINERGIC P2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847155078     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706994     Document Type: Article

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