Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: Critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition

Journal of Biological Chemistry

Volumn 282, Issue 51, 2007, Pages 36879-36886

  Coddou, Claudio ^a   Acuña Castillo, Claudio ^c   Bull, Paulina ^a,b   Huidobro Toro, J Pablo ^a,b  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; COPPER; MUTAGENESIS; NEUROLOGY; ZINC;

CHANNEL FOLDING; LIGAND-GATED IONIC CHANNELS; TRACE METAL INTERACTION; ZINC MODULATION;

LIGANDS;

ADENOSINE TRIPHOSPHATE; ALANINE; ASPARTIC ACID; COMPLEMENTARY DNA; COPPER; CYSTEINE; HISTIDINE; MUTANT PROTEIN; PURINERGIC P2X4 RECEPTOR; THREONINE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ION CHANNEL GATING; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NEURONS; OOCYTES; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, PURINERGIC P2; XENOPUS LAEVIS; ZINC;

RATTUS; XENOPUS LAEVIS;

EID: 37549023848     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706925200     Document Type: Article

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