Ethylene glycol-linked amino acid diester prodrugs of oleanolic acid for PepT1-mediated transport: Synthesis, intestinal permeability and pharmacokinetics

Molecular Pharmaceutics

Volumn 9, Issue 8, 2012, Pages 2127-2135

  Cao, Feng ^a   Jia, Jinghao ^a   Yin, Zhi ^a   Gao, Yahan ^a   Sha, Lei ^a   Lai, Yisheng ^a   Ping, Qineng ^a   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

bioavailability; ester prodrug; in situ single pass intestinal perfusion; oleanolic acid; peptide transporter 1; pharmacokinetics

Indexed keywords

CARBOXYLIC ACID; ETHYLENE GLYCOL; GLYCYLSARCOSINE; OLEANOLIC ACID; PEPTIDE TRANSPORTER 1; PRODRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; INTESTINE MUCOSA PERMEABILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ETHYLENE GLYCOL; INTESTINAL ABSORPTION; MALE; OLEANOLIC ACID; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84864658686     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200447r     Document Type: Article

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