Determination of oleanolic acid in human plasma and study of its pharmacokinetics in Chinese healthy male volunteers by HPLC tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 40, Issue 1, 2006, Pages 190-196

  Song, Min ^a   Hang, Tai Jun ^a   Wang, Ying ^a   Jiang, Li ^a   Wu, Xiao Luan ^a   Zhang, Zhengxing ^a   Shen, Jianping ^b   Zhang, Yindi ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

HPLC ESI MS MS; Oleanolic acid; Pharmacokinetics

Indexed keywords

ACETIC ACID ETHYL ESTER; AMMONIUM ACETATE; GLYCYRRHETINIC ACID; METHANOL; NITROGEN; OLEANOLIC ACID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHINESE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VOLUNTEER;

ACETATES; ADULT; AREA UNDER CURVE; CALIBRATION; CHEMISTRY, ANALYTICAL; CHEMISTRY, PHARMACEUTICAL; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCYRRHETINIC ACID; HUMANS; MALE; METHANOL; MODELS, CHEMICAL; OLEANOLIC ACID; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

EID: 30344458801     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.06.034     Document Type: Article

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