Formulation, biological and pharmacokinetic studies of sucrose ester-stabilized nanosuspensions of oleanolic acid

Pharmaceutical Research

Volumn 28, Issue 8, 2011, Pages 2020-2033

  Li, Wenji ^a   Das, Surajit ^a   Ng, Ka Yun ^a   Heng, Paul W S ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

bioavailability; dissolution rate; hydrophobic drug; oleanolic acid; saturation solubility; sucrose ester; surfactant stabilized nanosuspensions

Indexed keywords

OLEANOLIC ACID; SUCROSE ESTER DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DOSAGE FORM; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG UPTAKE; EMULSION; EVAPORATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MALE; MAXIMUM PLASMA CONCENTRATION; NANOENCAPSULATION; NANOSUSPENSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TEMPERATURE DEPENDENCE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; ESTERS; EXCIPIENTS; HUMANS; NANOPARTICLES; OLEANOLIC ACID; PARTICLE SIZE; SOLUBILITY; SUCROSE;

EID: 79961170952     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0428-3     Document Type: Article

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