-
1
-
-
0032144333
-
The effect of L-3,4-dihydroxyphenylalanine (=DOPA) on akinesia in parkinsonism
-
DOI 10.1016/S1353-8020(98)00013-3, PII S1353802098000133
-
The effect of l-3,4-dihydroxyphenylalanine (= DOPA) on akinesia in Parkinsonism. Birkmayer W, Hornykiewicz O, Parkinsonism Relat Disord 1998 4 59 60 10.1016/S1353-8020(98)00013-3 18591089 (Pubitemid 28525350)
-
(1998)
Parkinsonism and Related Disorders
, vol.4
, Issue.2
, pp. 59-60
-
-
Birkmayer, W.1
Hornykiewicz, O.2
-
2
-
-
65449135642
-
Levodopa: Past, present and future
-
10.1159/000215875 19407449
-
Levodopa: Past, present and future. Hauser R, Eur Neurol 2009 62 1 8 10.1159/000215875 19407449
-
(2009)
Eur Neurol
, vol.62
, pp. 1-8
-
-
Hauser, R.1
-
3
-
-
57349093766
-
Levodopa for the treatment of Parkinson's disease
-
10.1056/NEJMct0800326
-
Levodopa for the treatment of Parkinson's disease. LeWitt PA, N Eng J Med 2008 359 2468 2476 10.1056/NEJMct0800326
-
(2008)
N Eng J Med
, vol.359
, pp. 2468-2476
-
-
Lewitt, P.A.1
-
4
-
-
66949117423
-
The scientific and clinical basis for the treatment of Parkinson's disease
-
10.1212/WNL.0b013e3181a1d44c 19470958
-
The scientific and clinical basis for the treatment of Parkinson's disease. Olanow CW, Stern MB, Sethi K, Neurology 2009 72 Suppl 4 1 S136 10.1212/WNL.0b013e3181a1d44c 19470958
-
(2009)
Neurology
, vol.72
, Issue.SUPPL. 4
-
-
Olanow, C.W.1
Stern, M.B.2
Sethi, K.3
-
5
-
-
0026526135
-
Levodopa: Pharmacology, pharmacokinetics, and pharmacodynamics
-
1584186
-
Levodopa: pharmacology, pharmacokinetics, and pharmacodynamics. Juncos JL, Neurol Clin 1992 10 487 509 1584186
-
(1992)
Neurol Clin
, vol.10
, pp. 487-509
-
-
Juncos, J.L.1
-
6
-
-
58149180322
-
Inter- and intra-individual variation in l-dopa pharmacokinetics in the treatment of Parkinson's disease
-
10.1016/S1353-8020(09)70007-0 19131037
-
Inter- and intra-individual variation in l-dopa pharmacokinetics in the treatment of Parkinson's disease. Nomoto M, Nishikawa N, Nagai M, Yabe H, Nakatsuka A, Moritoyo H, Moritoyo T, Kubo M, Parkinsonism Relat Disord 2009 15 Suppl 1 21 S24 10.1016/S1353-8020(09)70007-0 19131037
-
(2009)
Parkinsonism Relat Disord
, vol.15
, Issue.SUPPL. 1
-
-
Nomoto, M.1
Nishikawa, N.2
Nagai, M.3
Yabe, H.4
Nakatsuka, A.5
Moritoyo, H.6
Moritoyo, T.7
Kubo, M.8
-
7
-
-
50049087567
-
Molecular mechanisms of l-dopa -induced dyskinesia
-
10.1038/nrn2471 18714325
-
Molecular mechanisms of l-dopa -induced dyskinesia. Jenner P, Nat Rev Neurosci 2008 9 665 677 10.1038/nrn2471 18714325
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 665-677
-
-
Jenner, P.1
-
8
-
-
65449189759
-
Optimising levodopa therapy
-
10.1007/s10072-008-1051-x 19381767
-
Optimising levodopa therapy. Abbruzzese G, Neurol Sci 2008 29 377 S379 10.1007/s10072-008-1051-x 19381767
-
(2008)
Neurol Sci
, vol.29
-
-
Abbruzzese, G.1
-
9
-
-
0027497673
-
The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man
-
The effect of l-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man. Lennernas H, Nilsson D, Aquilonius SM, Ahrenstedt O, Knutson L, Paalzow LK, Br J Clin Pharmacol 1993 35 243 250 8471400 (Pubitemid 23074047)
-
(1993)
British Journal of Clinical Pharmacology
, vol.35
, Issue.3
, pp. 243-250
-
-
Lennernas, H.1
Nilsson, D.2
Aquilonius, S.-M.3
Ahrenstedt, O.4
Knutson, L.5
Paalzow, L.K.6
-
10
-
-
0028262953
-
Dietary factors in the management of Parkinson's disease
-
Dietary factors in the management of Parkinson's Disease. Kempster PA, Wahlqvist ML, Nutr Rev 1994 52 51 58 8183469 (Pubitemid 24090161)
-
(1994)
Nutrition Reviews
, vol.52
, Issue.2
, pp. 51-58
-
-
Kempster, P.A.1
Wahlqvist, M.L.2
-
11
-
-
0037243824
-
Effects of food on the pharmacokinetics of levodopa in a dual-release formulation
-
DOI 10.1016/S0939-6411(02)00124-8
-
Effects of food on the pharmacokinetics of levodopa in a dual-release formulation. Crevoisier C, Zerr P, Calvi-Gries F, Nilsen T, Eur J Pharm Biopharm 2003 55 71 76 10.1016/S0939-6411(02)00124-8 12551706 (Pubitemid 36120497)
-
(2003)
European Journal of Pharmaceutics and Biopharmaceutics
, vol.55
, Issue.1
, pp. 71-76
-
-
Crevoisier, C.1
Zerr, P.2
Calvi-Gries, F.3
Nilsen, T.4
-
12
-
-
0034825881
-
Intestinal peptide transport: Ex vivo uptake studies and localization of peptide carrier PEPT1
-
11518682
-
Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Groneberg DA, Döring F, Eynott PR, Fischer A, Daniel H, Am J Physiol Gastrointest Liver Physiol 2001 281 697 G704 11518682
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.281
-
-
Groneberg, D.A.1
Döring, F.2
Eynott, P.R.3
Fischer, A.4
Daniel, H.5
-
13
-
-
0036018543
-
Transport of peptidomimetic drugs by the intestinal di/tri-peptide transporter, PepT1
-
DOI 10.1034/j.1600-0773.2002.900601.x
-
Transport of peptidomimetic drugs by the intestinal di/tri-peptide transporter, PepT1. Brodin B, Nielsen CU, Steffansen B, Frokjaer S, Pharmacol Toxicol 2002 90 285 296 10.1034/j.1600-0773.2002.900601.x 12403049 (Pubitemid 34713193)
-
(2002)
Pharmacology and Toxicology
, vol.90
, Issue.6
, pp. 285-296
-
-
Brodin, B.1
Nielsen, C.U.2
Steffansen, B.3
Frokjaer, S.4
-
14
-
-
57749202044
-
Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats
-
10.1007/s11095-008-9703-3 18784906
-
Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats. Hironaka T, Itokawa S, Ogawara K, Higaki K, Kimura T, Pharm Res 2009 26 40 50 10.1007/s11095-008-9703-3 18784906
-
(2009)
Pharm Res
, vol.26
, pp. 40-50
-
-
Hironaka, T.1
Itokawa, S.2
Ogawara, K.3
Higaki, K.4
Kimura, T.5
-
15
-
-
54349109822
-
Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited
-
10.1124/jpet.108.143339 18713951
-
Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. Knütter I, Wollesky C, Kottra G, Hahn MG, Fischer W, Zebisch K, Neubert RH, Daniel H, Brandsch M, J Pharmacol Exp Ther 2008 327 432 41 10.1124/jpet.108.143339 18713951
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 432-41
-
-
Knütter, I.1
Wollesky, C.2
Kottra, G.3
Hahn, M.G.4
Fischer, W.5
Zebisch, K.6
Neubert, R.H.7
Daniel, H.8
Brandsch, M.9
-
16
-
-
0346098120
-
+/peptide symporter PEPT1: Structure-affinity relationships
-
DOI 10.1016/S0928-0987(03)00142-8
-
The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Brandsch M, Knutter L, Leibach FH, Eur J Pharm Sci 2004 21 53 60 10.1016/S0928-0987(03)00142-8 14706811 (Pubitemid 38050203)
-
(2004)
European Journal of Pharmaceutical Sciences
, vol.21
, Issue.1
, pp. 53-60
-
-
Brandsch, M.1
Knutter, I.2
Leibach, F.H.3
-
17
-
-
33745134044
-
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding
-
DOI 10.1021/jm0511029
-
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN, J Med Chem 2006 49 3636 3644 10.1021/jm0511029 16759105 (Pubitemid 43902468)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.12
, pp. 3636-3644
-
-
Vig, B.S.1
Stouch, T.R.2
Timoszyk, J.K.3
Quan, Y.4
Wall, D.A.5
Smith, R.L.6
Faria, T.N.7
-
18
-
-
39449106420
-
+/peptide symporter, hPEPT1: Affinity prediction using alignment-independent descriptors
-
DOI 10.1021/ci700346y
-
+/peptide symporter, hPEPT1: Affinity prediction using alignment-independent descriptors. Larsen SB, Jørgensen FS, Olsen L, J Chem Inf Model 2008 48 233 241 10.1021/ci700346y 18092768 (Pubitemid 351271069)
-
(2008)
Journal of Chemical Information and Modeling
, vol.48
, Issue.1
, pp. 233-241
-
-
Larsen, S.B.1
Jorgensen, F.S.2
Olsen, L.3
-
19
-
-
68149161029
-
Transport of drugs by proton-coupled peptide transporters: Pearls and pitfalls
-
10.1517/17425250903042292 19519280
-
Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls. Brandsh M, Expert Opin Drug Metab Toxicol 2009 5 887 905 10.1517/17425250903042292 19519280
-
(2009)
Expert Opin Drug Metab Toxicol
, vol.5
, pp. 887-905
-
-
Brandsh, M.1
-
20
-
-
2942612987
-
Membrane transporter/receptor-targeted prodrug design: Strategies for human and veterinary drug development
-
DOI 10.1016/j.addr.2004.02.006, PII S0169409X04000699, Veterinary Drug Delivery: Part VI
-
Membrane transporter/receptor-targeted prodrug design: Strategies for human and veterinary drug development. Majumdar S, Duvvuri S, Mitra AK, Adv Drug Deliv Rev 2004 56 1437 1452 10.1016/j.addr.2004.02.006 15191791 (Pubitemid 38748825)
-
(2004)
Advanced Drug Delivery Reviews
, vol.56
, Issue.10
, pp. 1437-1452
-
-
Majumdar, S.1
Duvvuri, S.2
Mitra, A.K.3
-
21
-
-
15844431965
-
Intestinal absorption studies on peptide mimetic α-methyldopa prodrugs
-
Intestinal absorption studies on peptide mimetic alpha-methyldopa prodrugs. Wang HP, Lu HH, Lee JS, Cheng CY, Mah JR, Hsu WL, Yen CF, Lin CJ, Kuo HS, J Pharm Pharmacol 1996 48 270 276 8737052 (Pubitemid 26159142)
-
(1996)
Journal of Pharmacy and Pharmacology
, vol.48
, Issue.3
, pp. 270-276
-
-
Wang, H.-P.O.1
Lu, H.-H.2
Lee, J.-S.3
Cheng, C.-Y.4
Mah, J.-R.5
Ku, C.-Y.I.6
Hsu, W.7
Yen, C.-F.8
Lin, C.-J.9
Kuo, H.S.10
-
22
-
-
77949286408
-
Biological Transporters as Target for New Drug Design
-
10.1016/S1878-3317(09)60008-5
-
Biological Transporters as Target for New Drug Design. Wang HP, Wang CL, J Exp Clin Med 2010 1 31 38 10.1016/S1878-3317(09)60008-5
-
(2010)
J Exp Clin Med
, vol.1
, pp. 31-38
-
-
Wang, H.P.1
Wang, C.L.2
-
23
-
-
0011745555
-
Preparation and use of renal and intestinal plasma membrane vesicles for toxicological studies
-
IRL press, Oxford Snell K, Mullock B 1
-
Preparation and use of renal and intestinal plasma membrane vesicles for toxicological studies. Sheikh MI, Muller JV, Biochemical Toxicology: A Practical Approach IRL press, Oxford, Snell K, Mullock B, 1 1987 153 182
-
(1987)
Biochemical Toxicology: A Practical Approach
, pp. 153-182
-
-
Sheikh, M.I.1
Muller, J.V.2
-
24
-
-
0037308045
-
Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: Competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2
-
DOI 10.1124/jpet.102.044313
-
Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2. Anand BS, Patel J, Mitra AK, J Pharmacol Exp Ther 2003 304 781 791 10.1124/jpet.102.044313 12538834 (Pubitemid 36152357)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.304
, Issue.2
, pp. 781-791
-
-
Anand, B.S.1
Patel, J.2
Mitra, A.K.3
-
25
-
-
0022512635
-
+ gradient-dependent transport of aminocephalosporins in rat intestinal brush-border membrane vesicles. Role of dipeptide transport system
-
DOI 10.1016/0006-2952(86)90292-3
-
+ gradient-dependent transport of aminocephalosporins in rat intestinal brush-border membrane vesicles. Okano T, Inui K, Takano M, Hori R, Biochem Pharmacol 1986 35 1781 1786 10.1016/0006-2952(86)90292-3 3718527 (Pubitemid 16046199)
-
(1986)
Biochemical Pharmacology
, vol.35
, Issue.11
, pp. 1781-1786
-
-
Okano, T.1
Inui, K.2
Takano, M.3
Hori, R.4
-
26
-
-
0026567139
-
Influence of d-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs
-
10.1002/jps.2600810105 1619565
-
Influence of d-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs. Lu HH, Thomas J, Fleisher D, J Pharm Sci 1992 81 21 25 10.1002/jps.2600810105 1619565
-
(1992)
J Pharm Sci
, vol.81
, pp. 21-25
-
-
Lu, H.H.1
Thomas, J.2
Fleisher, D.3
-
27
-
-
0024505073
-
Use of the peptide carrier system to improve the intestinal absorption of L-α-methyldopa: Carrier kinetics, instestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-α-methyldopa
-
DOI 10.1023/A:1015855820488
-
Use of the peptide carrier system to improve the intestinal absorption of l-alpha-methyldopa: Carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of l-alpha-methyldopa. Hu M, Subramanian P, Mosberg HI, Amidon GL, Pharm Res 1989 6 66 70 10.1023/A:1015855820488 2717522 (Pubitemid 19060826)
-
(1989)
Pharmaceutical Research
, vol.6
, Issue.1
, pp. 66-70
-
-
Hu, M.1
Subramanian, P.2
Mosberg, H.I.3
Amidon, G.L.4
-
28
-
-
0023715382
-
Estimating human oral fraction dose absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
-
DOI 10.1023/A:1015927004752
-
Estimating human oral fraction dose absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Amidon GL, Sinko PJ, Fleisher D, Pharm Res 1988 5 651 654 10.1023/A: 1015927004752 3244618 (Pubitemid 18263612)
-
(1988)
Pharmaceutical Research
, vol.5
, Issue.10
, pp. 651-654
-
-
Amidon, G.L.1
Sinko, P.J.2
Fleisher, D.3
-
29
-
-
0019274427
-
The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time
-
DOI 10.1007/BF01059549
-
The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time. Reigelman S, Collier P, J Pharmacokinet Biopharm 1980 8 509 534 10.1007/BF01059549 7252794 (Pubitemid 11136588)
-
(1980)
Journal of Pharmacokinetics and Biopharmaceutics
, vol.8
, Issue.5
, pp. 509-534
-
-
Riegelmen, S.1
Collier, P.2
-
30
-
-
0015731028
-
Utilization of area under the curve to elucidate the disposition of an extensively biotransformed drug
-
Utilization of area under the curve to elucidate the disposition of an extensively biotransformed drug. Kaplan SA, Jack ML, Cotler S, Alexander K, J Pharmacokinet Pharmacodyn 1973 1 201 216
-
(1973)
J Pharmacokinet Pharmacodyn
, vol.1
, pp. 201-216
-
-
Kaplan, S.A.1
Jack, M.L.2
Cotler, S.3
Alexander, K.4
-
32
-
-
0027449341
-
Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats
-
DOI 10.1016/0006-8993(93)90576-9
-
Correlation of apomorphine and amphetamine induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Hudson JL, van Horne CG, Stromberg I, Brock S, Clayton J, Masserano J, Hoffer BJ, Gerhard GA, Brain Res 1993 626 167 174 10.1016/0006-8993(93)90576-9 8281427 (Pubitemid 23306825)
-
(1993)
Brain Research
, vol.626
, Issue.1-2
, pp. 167-174
-
-
Hudson, J.L.1
Van Horne, C.G.2
Stromberg, I.3
Brock, S.4
Clayton, J.5
Masserano, J.6
Hoffer, B.J.7
Gerhardt, G.A.8
-
33
-
-
19444370500
-
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice
-
DOI 10.1016/j.bbr.2005.02.023, PII S0166432805000707
-
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice. Iancu R, Mohapel P, Brundin P, Paul G, Behav Brain Res 2005 162 1 10 10.1016/j.bbr.2005.02.023 15922062 (Pubitemid 40726275)
-
(2005)
Behavioural Brain Research
, vol.162
, Issue.1
, pp. 1-10
-
-
Iancu, R.1
Mohapel, P.2
Brundin, P.3
Paul, G.4
-
34
-
-
0035344211
-
Experimental models of Parkinson's disease
-
DOI 10.1038/35072550
-
Experimental models of Parkinson's disease. Beal MF, Nat Rev Neurosci 2001 2 325 332 10.1038/35072550 11331916 (Pubitemid 33680574)
-
(2001)
Nature Reviews Neuroscience
, vol.2
, Issue.5
, pp. 325-332
-
-
Beal, M.F.1
-
35
-
-
23944434938
-
The unilateral 6-OHDA rat model of Parkinson's disease revisited: An electromyographic and behavioural analysis
-
DOI 10.1111/j.1460-9568.2005.04238.x
-
The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis. Metz GA, Tse A, Ballermann M, Smith LK, Fouad K, Eur J Neurosci 2005 22 735 744 10.1111/j.1460-9568.2005.04238.x 16101755 (Pubitemid 41192283)
-
(2005)
European Journal of Neuroscience
, vol.22
, Issue.3
, pp. 735-744
-
-
Metz, G.A.1
Tse, A.2
Ballermann, M.3
Smith, L.K.4
Fouad, K.5
-
36
-
-
35349012642
-
Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo
-
DOI 10.1016/j.addr.2007.06.016, PII S0169409X07001706, Prediction of Therapeutic and Drug Delivery Outcomes Using Animal Models
-
Animal data: The contribution of the Ussing chamber and perfusion system to predicting human oral drug delivery in vivo. Lennernäs H, Adv Drug Deliv Rev 2007 59 1103 1120 10.1016/j.addr.2007.06.016 17900749 (Pubitemid 47615203)
-
(2007)
Advanced Drug Delivery Reviews
, vol.59
, Issue.11
, pp. 1103-1120
-
-
Lennernas, H.1
-
37
-
-
0023940704
-
Determination of intrinsic membrane transport parameters from perfused intestine experiments: A boundary layer approach to estimating the aqueous and unbiased membrane permeabilities
-
10.1016/S0022-5193(88)80123-1 3419195
-
Determination of intrinsic membrane transport parameters from perfused intestine experiments: a boundary layer approach to estimating the aqueous and unbiased membrane permeabilities. Johnson DA, Amidon GL, J Theor Biol 1988 131 93 106 10.1016/S0022-5193(88)80123-1 3419195
-
(1988)
J Theor Biol
, vol.131
, pp. 93-106
-
-
Johnson, D.A.1
Amidon, G.L.2
|